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Review article: adipocytokines and insulin resistance.

Abstract

Insulin resistance has been implicated as one possible factor that links visceral obesity to unfavourable metabolic and cardiovascular consequences. However, the mechanism whereby adipose tissue causes alterations in insulin action remains unclear. White adipose tissue is secreting several hormones, particularly leptin and adiponectin, and a variety of other protein signals: the adipocytokines. They include proteins involved in the regulation of energy balance, lipid and glucose metabolism as well as angiogenesis, vascular and blood pressure regulation. Visceral obesity and inflammation within white adipose tissue may be a crucial step contributing to the emergence of insulin resistance, type 2 diabetes and atherosclerosis. A growing list of adipocytokines involved in inflammation (IL-1beta, IL-6, IL-8, IL-10, TNF-alpha, TGF-beta,) and the acute-phase response (serum amyloid A, PAI-1) have been found to be increased in the metabolic syndrome. It is, however, unclear as to the extent adipose tissue contributes quantitatively to the elevated circulating levels of these factors in obesity and how they may affect the insulin-dependent tissues. This review describes the role of the currently known adipocytokines and hormones released by adipose tissue in generating the insulin resistance state and the chronic inflammatory profile which frequently goes together with visceral obesity.

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  • Authors+Show Affiliations

    ,

    Endocrine-metabolic laboratory, Internal Medicine, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy. roberto.vettor@unipd.it

    , ,

    Source

    Alimentary pharmacology & therapeutics 22 Suppl 2: 2005 Nov pg 3-10

    MeSH

    Adiponectin
    Adipose Tissue
    Complement C3a
    Humans
    Insulin Resistance
    Interleukin-6
    Leptin
    Models, Biological
    Peptides
    Resistin
    Tumor Necrosis Factor-alpha

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16225463

    Citation

    Vettor, R, et al. "Review Article: Adipocytokines and Insulin Resistance." Alimentary Pharmacology & Therapeutics, vol. 22 Suppl 2, 2005, pp. 3-10.
    Vettor R, Milan G, Rossato M, et al. Review article: adipocytokines and insulin resistance. Aliment Pharmacol Ther. 2005;22 Suppl 2:3-10.
    Vettor, R., Milan, G., Rossato, M., & Federspil, G. (2005). Review article: adipocytokines and insulin resistance. Alimentary Pharmacology & Therapeutics, 22 Suppl 2, pp. 3-10.
    Vettor R, et al. Review Article: Adipocytokines and Insulin Resistance. Aliment Pharmacol Ther. 2005;22 Suppl 2:3-10. PubMed PMID: 16225463.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Review article: adipocytokines and insulin resistance. AU - Vettor,R, AU - Milan,G, AU - Rossato,M, AU - Federspil,G, PY - 2005/10/18/pubmed PY - 2006/2/10/medline PY - 2005/10/18/entrez SP - 3 EP - 10 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 22 Suppl 2 N2 - Insulin resistance has been implicated as one possible factor that links visceral obesity to unfavourable metabolic and cardiovascular consequences. However, the mechanism whereby adipose tissue causes alterations in insulin action remains unclear. White adipose tissue is secreting several hormones, particularly leptin and adiponectin, and a variety of other protein signals: the adipocytokines. They include proteins involved in the regulation of energy balance, lipid and glucose metabolism as well as angiogenesis, vascular and blood pressure regulation. Visceral obesity and inflammation within white adipose tissue may be a crucial step contributing to the emergence of insulin resistance, type 2 diabetes and atherosclerosis. A growing list of adipocytokines involved in inflammation (IL-1beta, IL-6, IL-8, IL-10, TNF-alpha, TGF-beta,) and the acute-phase response (serum amyloid A, PAI-1) have been found to be increased in the metabolic syndrome. It is, however, unclear as to the extent adipose tissue contributes quantitatively to the elevated circulating levels of these factors in obesity and how they may affect the insulin-dependent tissues. This review describes the role of the currently known adipocytokines and hormones released by adipose tissue in generating the insulin resistance state and the chronic inflammatory profile which frequently goes together with visceral obesity. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16225463/Review_article:_adipocytokines_and_insulin_resistance_ L2 - https://doi.org/10.1111/j.1365-2036.2005.02587.x DB - PRIME DP - Unbound Medicine ER -