Tags

Type your tag names separated by a space and hit enter

The fractal nature of human gastro-oesophageal reflux.
Aliment Pharmacol Ther 2005; 22(9):823-30AP

Abstract

BACKGROUND

We are unaware of the analyses of time series data resulting from 24 h recordings of human gastric or oesophageal pH. As a result, we have no understanding of the quantitative changes in gastric or oesophageal acidity over time, the patterns that might characterize these changes, or the physiological significance of gastro-oesophageal reflux.

AIM

To examine the time series for gastric and oesophageal pH.

METHODS

Detrended fluctuation analysis and lag analysis were used to analyse data from 24 h recordings of oesophageal and gastric pH in five normal subjects and five subjects with gastro-oesophageal reflux disease.

RESULTS

Analyses of the patterns of gastric and oesophageal pH over time in normal subjects and subjects with gastro-oesophageal reflux disease indicate that the fluctuations in pH are self-similar across different time scales and are consistent with an underlying fractal process. Furthermore, there is a significant statistical association between sequential pH values separated by as much as 2.2 h.

CONCLUSIONS

We hypothesize that the self-similar, fractal pattern encodes information about gastric acidity and that the oesophagus decodes this information and, when appropriate, may signal the stomach to reduce gastric acidity. Subjects with gastro-oesophageal reflux disease might have an impaired oesophageal-gastric feedback mechanism that results in increased gastric acid, which reflux from the stomach into the oesophagus.

Authors+Show Affiliations

Science for Organizations, Inc., Chatham, NJ 07928, USA. gardnerj@scifororg.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16225491

Citation

Gardner, J D., et al. "The Fractal Nature of Human Gastro-oesophageal Reflux." Alimentary Pharmacology & Therapeutics, vol. 22, no. 9, 2005, pp. 823-30.
Gardner JD, Young W, Sloan S, et al. The fractal nature of human gastro-oesophageal reflux. Aliment Pharmacol Ther. 2005;22(9):823-30.
Gardner, J. D., Young, W., Sloan, S., Robinson, M., & Miner, P. B. (2005). The fractal nature of human gastro-oesophageal reflux. Alimentary Pharmacology & Therapeutics, 22(9), pp. 823-30.
Gardner JD, et al. The Fractal Nature of Human Gastro-oesophageal Reflux. Aliment Pharmacol Ther. 2005 Nov 1;22(9):823-30. PubMed PMID: 16225491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The fractal nature of human gastro-oesophageal reflux. AU - Gardner,J D, AU - Young,W, AU - Sloan,S, AU - Robinson,M, AU - Miner,P B,Jr PY - 2005/10/18/pubmed PY - 2006/2/10/medline PY - 2005/10/18/entrez SP - 823 EP - 30 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 22 IS - 9 N2 - BACKGROUND: We are unaware of the analyses of time series data resulting from 24 h recordings of human gastric or oesophageal pH. As a result, we have no understanding of the quantitative changes in gastric or oesophageal acidity over time, the patterns that might characterize these changes, or the physiological significance of gastro-oesophageal reflux. AIM: To examine the time series for gastric and oesophageal pH. METHODS: Detrended fluctuation analysis and lag analysis were used to analyse data from 24 h recordings of oesophageal and gastric pH in five normal subjects and five subjects with gastro-oesophageal reflux disease. RESULTS: Analyses of the patterns of gastric and oesophageal pH over time in normal subjects and subjects with gastro-oesophageal reflux disease indicate that the fluctuations in pH are self-similar across different time scales and are consistent with an underlying fractal process. Furthermore, there is a significant statistical association between sequential pH values separated by as much as 2.2 h. CONCLUSIONS: We hypothesize that the self-similar, fractal pattern encodes information about gastric acidity and that the oesophagus decodes this information and, when appropriate, may signal the stomach to reduce gastric acidity. Subjects with gastro-oesophageal reflux disease might have an impaired oesophageal-gastric feedback mechanism that results in increased gastric acid, which reflux from the stomach into the oesophagus. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16225491/The_fractal_nature_of_human_gastro_oesophageal_reflux_ L2 - https://doi.org/10.1111/j.1365-2036.2005.02665.x DB - PRIME DP - Unbound Medicine ER -