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Detection of Leishmania infantum kinetoplast DNA in laryngeal tissue from an immunocompetent patient.
Hum Pathol. 2005 Oct; 36(10):1140-2.HP

Abstract

Mucosal leishmaniasis of the upper respiratory tract is usually associated with the visceral form or is found in immunosuppressed individuals. This report presents a case of isolated mucosal leishmaniasis in an immunocompetent patient, whose diagnosis mainly rested on histology and positive polymerase chain reaction result for Leishmania donovani in the laryngeal tissue. A 59-year-old man, who never lived outside Italy, showed a subglottic mucosal polypoid-like lesion. The typical morphological picture and positive polymerase chain reaction result for L donovani by DNA extracted from laryngeal biopsy specimens allowed the diagnosis of mucosal leishmaniasis. Specific amphotericin B therapy was started, resulting in clinical and endoscopic improvement. Increased knowledge about the histological and molecular tissue analysis of Leishmania enhances the diagnostic testing for mucosal leishmaniasis, as primary mucosal leishmaniasis may occur in both immunosuppresed and immunocompetent patients who travel to or reside in areas endemic for Leishmania.

Authors+Show Affiliations

Guddo F
Unità Operativa di Anatomia ed Istologia Patologica, Ospedale V. Cervello, Palermo 90148, Italy. francesca.guddo@tin.it
Gallo E
No affiliation info available
Cillari E
No affiliation info available
La Rocca AM
No affiliation info available
Moceo P
No affiliation info available
Leslie K
No affiliation info available
Colby T
No affiliation info available
Rizzo AG
No affiliation info available

MeSH

Amphotericin BAnimalsAntibodies, ProtozoanAntiprotozoal AgentsAzure StainsBiopsyBronchoscopyDNA, KinetoplastDNA, ProtozoanEndoscopyEnzyme-Linked Immunosorbent AssayHumansImmunocompetenceItalyLarynxLeishmania donovaniLeishmania infantumLeishmaniasis, VisceralMaleMiddle AgedPolymerase Chain ReactionStaining and LabelingTreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16226116

Citation

Guddo, Francesca, et al. "Detection of Leishmania Infantum Kinetoplast DNA in Laryngeal Tissue From an Immunocompetent Patient." Human Pathology, vol. 36, no. 10, 2005, pp. 1140-2.
Guddo F, Gallo E, Cillari E, et al. Detection of Leishmania infantum kinetoplast DNA in laryngeal tissue from an immunocompetent patient. Hum Pathol. 2005;36(10):1140-2.
Guddo, F., Gallo, E., Cillari, E., La Rocca, A. M., Moceo, P., Leslie, K., Colby, T., & Rizzo, A. G. (2005). Detection of Leishmania infantum kinetoplast DNA in laryngeal tissue from an immunocompetent patient. Human Pathology, 36(10), 1140-2.
Guddo F, et al. Detection of Leishmania Infantum Kinetoplast DNA in Laryngeal Tissue From an Immunocompetent Patient. Hum Pathol. 2005;36(10):1140-2. PubMed PMID: 16226116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of Leishmania infantum kinetoplast DNA in laryngeal tissue from an immunocompetent patient. AU - Guddo,Francesca, AU - Gallo,Elena, AU - Cillari,Enrico, AU - La Rocca,Anton Maria, AU - Moceo,Piero, AU - Leslie,Kevin, AU - Colby,Thomas, AU - Rizzo,Aroldo G, Y1 - 2005/09/06/ PY - 2004/11/09/received PY - 2005/07/05/accepted PY - 2005/10/18/pubmed PY - 2005/12/13/medline PY - 2005/10/18/entrez SP - 1140 EP - 2 JF - Human pathology JO - Hum Pathol VL - 36 IS - 10 N2 - Mucosal leishmaniasis of the upper respiratory tract is usually associated with the visceral form or is found in immunosuppressed individuals. This report presents a case of isolated mucosal leishmaniasis in an immunocompetent patient, whose diagnosis mainly rested on histology and positive polymerase chain reaction result for Leishmania donovani in the laryngeal tissue. A 59-year-old man, who never lived outside Italy, showed a subglottic mucosal polypoid-like lesion. The typical morphological picture and positive polymerase chain reaction result for L donovani by DNA extracted from laryngeal biopsy specimens allowed the diagnosis of mucosal leishmaniasis. Specific amphotericin B therapy was started, resulting in clinical and endoscopic improvement. Increased knowledge about the histological and molecular tissue analysis of Leishmania enhances the diagnostic testing for mucosal leishmaniasis, as primary mucosal leishmaniasis may occur in both immunosuppresed and immunocompetent patients who travel to or reside in areas endemic for Leishmania. SN - 0046-8177 UR - https://www.unboundmedicine.com/medline/citation/16226116/Detection_of_Leishmania_infantum_kinetoplast_DNA_in_laryngeal_tissue_from_an_immunocompetent_patient_ DB - PRIME DP - Unbound Medicine ER -