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Subclinical coronary artery atherosclerosis in patients with erectile dysfunction.

Abstract

OBJECTIVES

The purpose of our study was to assess the prevalence and extent of coronary artery atherosclerosis in asymptomatic patients with vascular erectile dysfunction (ED).

BACKGROUND

An association between ED and ischemic heart disease has been suggested, but it is unknown if it represents a marker of subclinical coronary atherosclerosis.

METHODS

We studied 70 consecutive patients with vascular ED, evaluated by penile Doppler, and 73 control subjects with no history of coronary artery disease. We measured traditional coronary risk factors, circulating levels of C-reactive protein (CRP), endothelial function by ultrasound of brachial artery, and coronary artery calcification by multi-slice computed tomography.

RESULTS

The patients and the control group were similar for age, race, and coronary risk score. Patients with ED had significantly higher high-sensitivity C-reactive protein levels (2.62 vs. 1.03 mg/l, p < 0.001). Flow-mediated dilation of the brachial artery was more impaired in patients with ED than in controls (2.36 vs. 3.92, p < 0.001). Coronary artery calcification was more frequent in individuals with ED than in control subjects (p = 0.01). Multiple logistic regression analysis showed that patients with ED had an overall odds ratio of 3.68 for having calcium score above the 75th percentile, compared to the controls.

CONCLUSIONS

Coronary atherosclerosis is more severe in patients with vascular ED; ED predicts the presence and extent of subclinical atherosclerosis independent of traditional risk factors for cardiovascular disease. Thus, ED may be considered an additional, early warning sign of coronary atherosclerosis.

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  • Authors+Show Affiliations

    ,

    Institute of Cardiology, University of Modena and Reggio Emilia, Modena, Italy. emiliochiurlia@virgilio.it

    , , , ,

    Source

    MeSH

    Calcinosis
    Coronary Artery Disease
    Humans
    Impotence, Vasculogenic
    Male
    Middle Aged
    Prevalence

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16226175

    Citation

    Chiurlia, Emilio, et al. "Subclinical Coronary Artery Atherosclerosis in Patients With Erectile Dysfunction." Journal of the American College of Cardiology, vol. 46, no. 8, 2005, pp. 1503-6.
    Chiurlia E, D'Amico R, Ratti C, et al. Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. J Am Coll Cardiol. 2005;46(8):1503-6.
    Chiurlia, E., D'Amico, R., Ratti, C., Granata, A. R., Romagnoli, R., & Modena, M. G. (2005). Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. Journal of the American College of Cardiology, 46(8), pp. 1503-6.
    Chiurlia E, et al. Subclinical Coronary Artery Atherosclerosis in Patients With Erectile Dysfunction. J Am Coll Cardiol. 2005 Oct 18;46(8):1503-6. PubMed PMID: 16226175.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. AU - Chiurlia,Emilio, AU - D'Amico,Roberto, AU - Ratti,Carlo, AU - Granata,Antonio R, AU - Romagnoli,Renato, AU - Modena,Maria G, Y1 - 2005/09/28/ PY - 2005/04/14/received PY - 2005/06/10/revised PY - 2005/06/20/accepted PY - 2005/10/18/pubmed PY - 2006/1/20/medline PY - 2005/10/18/entrez SP - 1503 EP - 6 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 46 IS - 8 N2 - OBJECTIVES: The purpose of our study was to assess the prevalence and extent of coronary artery atherosclerosis in asymptomatic patients with vascular erectile dysfunction (ED). BACKGROUND: An association between ED and ischemic heart disease has been suggested, but it is unknown if it represents a marker of subclinical coronary atherosclerosis. METHODS: We studied 70 consecutive patients with vascular ED, evaluated by penile Doppler, and 73 control subjects with no history of coronary artery disease. We measured traditional coronary risk factors, circulating levels of C-reactive protein (CRP), endothelial function by ultrasound of brachial artery, and coronary artery calcification by multi-slice computed tomography. RESULTS: The patients and the control group were similar for age, race, and coronary risk score. Patients with ED had significantly higher high-sensitivity C-reactive protein levels (2.62 vs. 1.03 mg/l, p < 0.001). Flow-mediated dilation of the brachial artery was more impaired in patients with ED than in controls (2.36 vs. 3.92, p < 0.001). Coronary artery calcification was more frequent in individuals with ED than in control subjects (p = 0.01). Multiple logistic regression analysis showed that patients with ED had an overall odds ratio of 3.68 for having calcium score above the 75th percentile, compared to the controls. CONCLUSIONS: Coronary atherosclerosis is more severe in patients with vascular ED; ED predicts the presence and extent of subclinical atherosclerosis independent of traditional risk factors for cardiovascular disease. Thus, ED may be considered an additional, early warning sign of coronary atherosclerosis. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/16226175/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(05)01721-3 DB - PRIME DP - Unbound Medicine ER -