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Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster.

Abstract

BACKGROUND

Type and composition of dietary fat intake is supposed to play an important role in carcinogenesis. Thus we investigated the effects of n-3, n-6 and n-9 polyunsaturated fatty acids (PUFA) on oxidative stress (lipidperoxidation) and tumour growth in ductal pancreatic cancer.

METHODS

Ninety male hamsters were randomized into 6 groups (gr.) (n=15) and allocated to 3 main dietary categories: gr. 1 and 2 received a standard high fat diet (SHF, rich in n-6 PUFA), while gr. 3 and 4 were fed with a diet containing a mixture of n-3, n-6 and n-9 PUFA (SMOF) and gr. 5 and 6 had free access to a diet rich in n-3 PUFA (FISH-OIL). Gr. 1, 3 and 5 received weekly subcutaneous (s.c.) injections of 10 mg N-nitrosobis-2-oxypropylamine (BOP)/kg body weight in order to induce ductal pancreatic adenocarcinoma. Healthy control gr. 2, 4 and 6 were treated with 0.5 ml 0.9% sodium chloride s.c. After 32 weeks all animals were sacrificed. Removed pancreata were weighed and analysed histologically and biochemically. Activities of glutathionperoxidase (GSH-Px), superoxiddismutase (SOD) and levels of lipidperoxidation were measured in samples of pancreatic carcinoma as well as in tumour-free pancreatic tissue.

RESULTS

While different diets did not significantly alter the overall incidence of histologically proven pancreatic adenocarcinoma, the number of macroscopically visible tumours was decreased in the FISH-OIL-gr.

CONCLUSION

Different diets did not significantly influence the incidence of histologically proven pancreatic adenocarcinoma. However, administration of a diet rich in n-3 PUFA (FISH-OIL) resulted in a decrease of macroscopically visible tumours, thus indicating its beneficial effects in respect to attenuation of tumour growth.

Authors+Show Affiliations

Clinic of General, Visceral, Vascular and Thoracic Surgery, Charité Campus Mitte, Humbold-University of Berlin, 10117 Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16226437

Citation

Gregor, J I., et al. "Does Enteral Nutrition of Dietary Polyunsaturated Fatty Acids Promote Oxidative Stress and Tumour Growth in Ductal Pancreatic Cancer? Experimental Trial in Syrian Hamster." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 74, no. 1, 2006, pp. 67-74.
Gregor JI, Heukamp I, Kilian M, et al. Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. Prostaglandins Leukot Essent Fatty Acids. 2006;74(1):67-74.
Gregor, J. I., Heukamp, I., Kilian, M., Kiewert, C., Schimke, I., Kristiansen, G., ... Wenger, F. A. (2006). Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 74(1), pp. 67-74.
Gregor JI, et al. Does Enteral Nutrition of Dietary Polyunsaturated Fatty Acids Promote Oxidative Stress and Tumour Growth in Ductal Pancreatic Cancer? Experimental Trial in Syrian Hamster. Prostaglandins Leukot Essent Fatty Acids. 2006;74(1):67-74. PubMed PMID: 16226437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. AU - Gregor,J I, AU - Heukamp,I, AU - Kilian,M, AU - Kiewert,C, AU - Schimke,I, AU - Kristiansen,G, AU - Walz,M K, AU - Jacobi,C A, AU - Wenger,F A, Y1 - 2005/10/13/ PY - 2005/04/10/received PY - 2005/08/28/accepted PY - 2005/10/18/pubmed PY - 2006/2/28/medline PY - 2005/10/18/entrez SP - 67 EP - 74 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 74 IS - 1 N2 - BACKGROUND: Type and composition of dietary fat intake is supposed to play an important role in carcinogenesis. Thus we investigated the effects of n-3, n-6 and n-9 polyunsaturated fatty acids (PUFA) on oxidative stress (lipidperoxidation) and tumour growth in ductal pancreatic cancer. METHODS: Ninety male hamsters were randomized into 6 groups (gr.) (n=15) and allocated to 3 main dietary categories: gr. 1 and 2 received a standard high fat diet (SHF, rich in n-6 PUFA), while gr. 3 and 4 were fed with a diet containing a mixture of n-3, n-6 and n-9 PUFA (SMOF) and gr. 5 and 6 had free access to a diet rich in n-3 PUFA (FISH-OIL). Gr. 1, 3 and 5 received weekly subcutaneous (s.c.) injections of 10 mg N-nitrosobis-2-oxypropylamine (BOP)/kg body weight in order to induce ductal pancreatic adenocarcinoma. Healthy control gr. 2, 4 and 6 were treated with 0.5 ml 0.9% sodium chloride s.c. After 32 weeks all animals were sacrificed. Removed pancreata were weighed and analysed histologically and biochemically. Activities of glutathionperoxidase (GSH-Px), superoxiddismutase (SOD) and levels of lipidperoxidation were measured in samples of pancreatic carcinoma as well as in tumour-free pancreatic tissue. RESULTS: While different diets did not significantly alter the overall incidence of histologically proven pancreatic adenocarcinoma, the number of macroscopically visible tumours was decreased in the FISH-OIL-gr. CONCLUSION: Different diets did not significantly influence the incidence of histologically proven pancreatic adenocarcinoma. However, administration of a diet rich in n-3 PUFA (FISH-OIL) resulted in a decrease of macroscopically visible tumours, thus indicating its beneficial effects in respect to attenuation of tumour growth. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/16226437/Does_enteral_nutrition_of_dietary_polyunsaturated_fatty_acids_promote_oxidative_stress_and_tumour_growth_in_ductal_pancreatic_cancer_Experimental_trial_in_Syrian_Hamster_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(05)00148-1 DB - PRIME DP - Unbound Medicine ER -