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Impact of rapid urine antigen tests to determine the etiology of community-acquired pneumonia in adults.
Respir Med. 2006 May; 100(5):884-91.RM

Abstract

STUDY OBJECTIVES

To evaluate the rapid urine antigen tests, including a new rapid immunochromatographic test (ICT) for the detection of the Streptococcus pneumoniae antigen and an enzyme immunoassay (EIA) for the detection of the Legionella antigen, in order to improve the diagnosis of community-acquired pneumonia (CAP) in adults.

DESIGN

Prospective study.

SETTING

A tertiary hospital in Spain.

PATIENTS

We consecutively recruited 107 adults with CAP evaluated at our hospital.

INTERVENTIONS

The analyses included blood and sputum cultures, pleural fluid culture (if present) and serologic studies. The detection of the Legionella pneumophila urinary antigen was performed by EIA, and the detection of S. pneumoniae antigen in urine samples was performed by counterimmunoelectrophoresis (CIE) and a rapid ICT.

RESULTS

Using conventional microbiologic tests we succeeded in performing the etiologic diagnosis of 39 out of the 107 cases (36.4%). The inclusion of rapid antigen detection techniques increased the percentage of diagnosis to 54.2%, which represents a total increase of 17.8% (P=0.034).

CONCLUSIONS

The data obtained in this study indicate that rapid urine antigen tests are very useful to determine CAP etiology in adults and, consequently, to quickly identify a group of patients in whom narrow spectrum antibiotics may be used.

Authors+Show Affiliations

Department of Pneumology, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain. feli120@separ.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16226441

Citation

Andreo, Felipe, et al. "Impact of Rapid Urine Antigen Tests to Determine the Etiology of Community-acquired Pneumonia in Adults." Respiratory Medicine, vol. 100, no. 5, 2006, pp. 884-91.
Andreo F, Domínguez J, Ruiz J, et al. Impact of rapid urine antigen tests to determine the etiology of community-acquired pneumonia in adults. Respir Med. 2006;100(5):884-91.
Andreo, F., Domínguez, J., Ruiz, J., Blanco, S., Arellano, E., Prat, C., Morera, J., & Ausina, V. (2006). Impact of rapid urine antigen tests to determine the etiology of community-acquired pneumonia in adults. Respiratory Medicine, 100(5), 884-91.
Andreo F, et al. Impact of Rapid Urine Antigen Tests to Determine the Etiology of Community-acquired Pneumonia in Adults. Respir Med. 2006;100(5):884-91. PubMed PMID: 16226441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of rapid urine antigen tests to determine the etiology of community-acquired pneumonia in adults. AU - Andreo,Felipe, AU - Domínguez,José, AU - Ruiz,Juan, AU - Blanco,Silvia, AU - Arellano,Elisabet, AU - Prat,Cristina, AU - Morera,Josep, AU - Ausina,Vicente, Y1 - 2005/10/12/ PY - 2004/10/28/received PY - 2005/06/05/revised PY - 2005/08/16/accepted PY - 2005/10/18/pubmed PY - 2007/2/17/medline PY - 2005/10/18/entrez SP - 884 EP - 91 JF - Respiratory medicine JO - Respir Med VL - 100 IS - 5 N2 - STUDY OBJECTIVES: To evaluate the rapid urine antigen tests, including a new rapid immunochromatographic test (ICT) for the detection of the Streptococcus pneumoniae antigen and an enzyme immunoassay (EIA) for the detection of the Legionella antigen, in order to improve the diagnosis of community-acquired pneumonia (CAP) in adults. DESIGN: Prospective study. SETTING: A tertiary hospital in Spain. PATIENTS: We consecutively recruited 107 adults with CAP evaluated at our hospital. INTERVENTIONS: The analyses included blood and sputum cultures, pleural fluid culture (if present) and serologic studies. The detection of the Legionella pneumophila urinary antigen was performed by EIA, and the detection of S. pneumoniae antigen in urine samples was performed by counterimmunoelectrophoresis (CIE) and a rapid ICT. RESULTS: Using conventional microbiologic tests we succeeded in performing the etiologic diagnosis of 39 out of the 107 cases (36.4%). The inclusion of rapid antigen detection techniques increased the percentage of diagnosis to 54.2%, which represents a total increase of 17.8% (P=0.034). CONCLUSIONS: The data obtained in this study indicate that rapid urine antigen tests are very useful to determine CAP etiology in adults and, consequently, to quickly identify a group of patients in whom narrow spectrum antibiotics may be used. SN - 0954-6111 UR - https://www.unboundmedicine.com/medline/citation/16226441/Impact_of_rapid_urine_antigen_tests_to_determine_the_etiology_of_community_acquired_pneumonia_in_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(05)00353-7 DB - PRIME DP - Unbound Medicine ER -