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Anti-babesial ellagic acid rhamnosides from the bark of Elaeocarpus parvifolius.
Phytochemistry. 2005 Nov; 66(21):2577-80.P

Abstract

Bioassay-guided investigation of the bark of Elaeocarpus parvifolius led to the isolation of three new ellagic acid derivatives, 4-O-methylellagic acid 3'-alpha-rhamnoside (2), 4-O-methylellagic acid 3'-(3''-O-acetyl)-alpha-rhamnoside (3), and 4-O-methylellagic acid 3'-(4''-O-acetyl)-alpha-rhamnoside (4) in addition to the known ellagic acid derivative, 4-O-methylellagic acid 3'-(2'',3''-di-O-acetyl)-alpha-rhamnoside (1). Their structures were elucidated on the basis of analysis of 1H NMR, 13C NMR, HMQC, HMBC and MS spectroscopic data. Compounds 1-4 were evaluated for their growth-inhibitory effect on Babesia gibsoni in vitro. Compounds 2 and 4 showed very weak activity, while compounds 1 and 3 showed moderate activity, with IC50 values of 28.5 and 52.1 microg/ml, respectively.

Authors+Show Affiliations

Elkhateeb A
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
Subeki
No affiliation info available
Takahashi K
No affiliation info available
Matsuura H
No affiliation info available
Yamasaki M
No affiliation info available
Yamato O
No affiliation info available
Maede Y
No affiliation info available
Katakura K
No affiliation info available
Yoshihara T
No affiliation info available
Nabeta K
No affiliation info available

MeSH

AnimalsAntiprotozoal AgentsBabesiaElaeocarpaceaeEllagic AcidMolecular StructurePlant Bark

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16226774

Citation

Elkhateeb, A, et al. "Anti-babesial Ellagic Acid Rhamnosides From the Bark of Elaeocarpus Parvifolius." Phytochemistry, vol. 66, no. 21, 2005, pp. 2577-80.
Elkhateeb A, Subeki , Takahashi K, et al. Anti-babesial ellagic acid rhamnosides from the bark of Elaeocarpus parvifolius. Phytochemistry. 2005;66(21):2577-80.
Elkhateeb, A., Subeki, ., Takahashi, K., Matsuura, H., Yamasaki, M., Yamato, O., Maede, Y., Katakura, K., Yoshihara, T., & Nabeta, K. (2005). Anti-babesial ellagic acid rhamnosides from the bark of Elaeocarpus parvifolius. Phytochemistry, 66(21), 2577-80.
Elkhateeb A, et al. Anti-babesial Ellagic Acid Rhamnosides From the Bark of Elaeocarpus Parvifolius. Phytochemistry. 2005;66(21):2577-80. PubMed PMID: 16226774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-babesial ellagic acid rhamnosides from the bark of Elaeocarpus parvifolius. AU - Elkhateeb,A, AU - Subeki,, AU - Takahashi,K, AU - Matsuura,H, AU - Yamasaki,M, AU - Yamato,O, AU - Maede,Y, AU - Katakura,K, AU - Yoshihara,T, AU - Nabeta,K, Y1 - 2005/10/14/ PY - 2005/05/16/received PY - 2005/07/21/revised PY - 2005/10/18/pubmed PY - 2006/7/26/medline PY - 2005/10/18/entrez SP - 2577 EP - 80 JF - Phytochemistry JO - Phytochemistry VL - 66 IS - 21 N2 - Bioassay-guided investigation of the bark of Elaeocarpus parvifolius led to the isolation of three new ellagic acid derivatives, 4-O-methylellagic acid 3'-alpha-rhamnoside (2), 4-O-methylellagic acid 3'-(3''-O-acetyl)-alpha-rhamnoside (3), and 4-O-methylellagic acid 3'-(4''-O-acetyl)-alpha-rhamnoside (4) in addition to the known ellagic acid derivative, 4-O-methylellagic acid 3'-(2'',3''-di-O-acetyl)-alpha-rhamnoside (1). Their structures were elucidated on the basis of analysis of 1H NMR, 13C NMR, HMQC, HMBC and MS spectroscopic data. Compounds 1-4 were evaluated for their growth-inhibitory effect on Babesia gibsoni in vitro. Compounds 2 and 4 showed very weak activity, while compounds 1 and 3 showed moderate activity, with IC50 values of 28.5 and 52.1 microg/ml, respectively. SN - 0031-9422 UR - https://www.unboundmedicine.com/medline/citation/16226774/Anti_babesial_ellagic_acid_rhamnosides_from_the_bark_of_Elaeocarpus_parvifolius_ DB - PRIME DP - Unbound Medicine ER -