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Decreased expression of TGF-beta type II receptor in bronchial glands of smokers with COPD.
Thorax. 2005 Dec; 60(12):998-1002.T

Abstract

BACKGROUND

The role of transforming growth factor-beta1 (TGF-beta1) in chronic obstructive pulmonary disease is still controversial, but it has been proposed that it may protect from mucus hypersecretion since it is able to downregulate mucin production. A study was undertaken to investigate the expression of TGF-beta1 and its type II receptor (TGF-beta RII) in the bronchial glands of smokers with COPD.

METHODS

The expression of TGF-beta(1) and TGF-beta RII were examined immunohistochemically in the bronchial glands of 24 smokers undergoing lung resection for solitary peripheral nodules: 12 with airflow limitation (smokers with COPD) and 12 with normal lung function.

RESULTS

The expression of TGF-beta1 in bronchial glands was similar in the two groups of subjects while that of TGF-beta RII was lower in smokers with COPD than in smokers with normal lung function (p=0.004). TGF-beta RII expression was inversely correlated with the values of Reid's index, a measure of gland size (p=0.02, r=-0.50).

CONCLUSIONS

In the bronchial glands of smokers with COPD there is decreased expression of TGF-beta RII which is associated with bronchial gland enlargement. These findings support the view that the absence of TGF-beta signalling may induce structural changes in the bronchial glands which, in turn, may promote mucus hypersecretion.

Authors+Show Affiliations

Department of Cardio-Thoracic and Vascular Sciences, Section of Respiratory Diseases, University of Padova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16227324

Citation

Baraldo, S, et al. "Decreased Expression of TGF-beta Type II Receptor in Bronchial Glands of Smokers With COPD." Thorax, vol. 60, no. 12, 2005, pp. 998-1002.
Baraldo S, Bazzan E, Turato G, et al. Decreased expression of TGF-beta type II receptor in bronchial glands of smokers with COPD. Thorax. 2005;60(12):998-1002.
Baraldo, S., Bazzan, E., Turato, G., Calabrese, F., Beghé, B., Papi, A., Maestrelli, P., Fabbri, L. M., Zuin, R., & Saetta, M. (2005). Decreased expression of TGF-beta type II receptor in bronchial glands of smokers with COPD. Thorax, 60(12), 998-1002.
Baraldo S, et al. Decreased Expression of TGF-beta Type II Receptor in Bronchial Glands of Smokers With COPD. Thorax. 2005;60(12):998-1002. PubMed PMID: 16227324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased expression of TGF-beta type II receptor in bronchial glands of smokers with COPD. AU - Baraldo,S, AU - Bazzan,E, AU - Turato,G, AU - Calabrese,F, AU - Beghé,B, AU - Papi,A, AU - Maestrelli,P, AU - Fabbri,L M, AU - Zuin,R, AU - Saetta,M, Y1 - 2005/10/14/ PY - 2005/10/18/pubmed PY - 2005/12/20/medline PY - 2005/10/18/entrez SP - 998 EP - 1002 JF - Thorax JO - Thorax VL - 60 IS - 12 N2 - BACKGROUND: The role of transforming growth factor-beta1 (TGF-beta1) in chronic obstructive pulmonary disease is still controversial, but it has been proposed that it may protect from mucus hypersecretion since it is able to downregulate mucin production. A study was undertaken to investigate the expression of TGF-beta1 and its type II receptor (TGF-beta RII) in the bronchial glands of smokers with COPD. METHODS: The expression of TGF-beta(1) and TGF-beta RII were examined immunohistochemically in the bronchial glands of 24 smokers undergoing lung resection for solitary peripheral nodules: 12 with airflow limitation (smokers with COPD) and 12 with normal lung function. RESULTS: The expression of TGF-beta1 in bronchial glands was similar in the two groups of subjects while that of TGF-beta RII was lower in smokers with COPD than in smokers with normal lung function (p=0.004). TGF-beta RII expression was inversely correlated with the values of Reid's index, a measure of gland size (p=0.02, r=-0.50). CONCLUSIONS: In the bronchial glands of smokers with COPD there is decreased expression of TGF-beta RII which is associated with bronchial gland enlargement. These findings support the view that the absence of TGF-beta signalling may induce structural changes in the bronchial glands which, in turn, may promote mucus hypersecretion. SN - 0040-6376 UR - https://www.unboundmedicine.com/medline/citation/16227324/Decreased_expression_of_TGF_beta_type_II_receptor_in_bronchial_glands_of_smokers_with_COPD_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=16227324 DB - PRIME DP - Unbound Medicine ER -