Tags

Type your tag names separated by a space and hit enter

Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E.

Abstract

BACKGROUND

Since increased oxidative stress may impair cognition and be a risk factor for dementia, there has been interest in determining whether use of antioxidants could protect against such events.

OBJECTIVE

To determine whether supplement use of vitamins C and/or E in a community-based sample of older African American and white individuals delayed incident dementia or Alzheimer's disease (AD).

METHODS

We selected a subgroup from the Duke Established Populations for Epidemiologic Studies of the Elderly, a longitudinal study of community-representative persons aged 65-105 years living in 5 adjacent counties in North Carolina, and followed them for dementia (1986-1987 through June 2000). Information gathered during in-home interviews included sociodemographic characteristics, health status, health service use, and vitamin use. Diagnosis of dementia and AD was based on evaluations using the clinical and neuropsychological batteries of the Consortium to Establish a Registry for Alzheimer's Disease, with final determination by consensus agreement of specialists using Diagnostic and Statistical Manual of Mental Disorders, third revision, and National Institute for Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders criteria.

RESULTS

Of 616 persons initially dementia-free (mean age 73 y; 62% female; 62% African American), 141 developed dementia, of whom 93 developed AD. Increased age and mobility problems were risk factors for dementia (only age for AD), while an increased number of outpatient visits reduced the likelihood of developing dementia. Neither use of any vitamins C and/or E (used by 8% of subjects at baseline) nor high-dose use reduced the time to dementia or AD.

CONCLUSIONS

In this community in the southeastern US where vitamin supplement use is low, use of vitamins C and/or E did not delay the incidence of dementia or AD.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Duke University Medical Center and Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Durham, NC 27710, USA. ggr@geri.duke.edu

    , , , , , ,

    Source

    The Annals of pharmacotherapy 39:12 2005 Dec pg 2009-14

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Antioxidants
    Ascorbic Acid
    Cohort Studies
    Data Interpretation, Statistical
    Dementia
    Female
    Humans
    Longitudinal Studies
    Male
    Neuropsychological Tests
    North Carolina
    Oxidative Stress
    Prospective Studies
    Vitamin E

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    16227448

    Citation

    Fillenbaum, Gerda G., et al. "Dementia and Alzheimer's Disease in Community-dwelling Elders Taking Vitamin C And/or Vitamin E." The Annals of Pharmacotherapy, vol. 39, no. 12, 2005, pp. 2009-14.
    Fillenbaum GG, Kuchibhatla MN, Hanlon JT, et al. Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. Ann Pharmacother. 2005;39(12):2009-14.
    Fillenbaum, G. G., Kuchibhatla, M. N., Hanlon, J. T., Artz, M. B., Pieper, C. F., Schmader, K. E., ... Gray, S. L. (2005). Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. The Annals of Pharmacotherapy, 39(12), pp. 2009-14.
    Fillenbaum GG, et al. Dementia and Alzheimer's Disease in Community-dwelling Elders Taking Vitamin C And/or Vitamin E. Ann Pharmacother. 2005;39(12):2009-14. PubMed PMID: 16227448.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. AU - Fillenbaum,Gerda G, AU - Kuchibhatla,Maragatha N, AU - Hanlon,Joseph T, AU - Artz,Margaret B, AU - Pieper,Carl F, AU - Schmader,Kenneth E, AU - Dysken,Maurice W, AU - Gray,Shelly L, Y1 - 2005/10/14/ PY - 2005/10/18/pubmed PY - 2006/3/16/medline PY - 2005/10/18/entrez SP - 2009 EP - 14 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 39 IS - 12 N2 - BACKGROUND: Since increased oxidative stress may impair cognition and be a risk factor for dementia, there has been interest in determining whether use of antioxidants could protect against such events. OBJECTIVE: To determine whether supplement use of vitamins C and/or E in a community-based sample of older African American and white individuals delayed incident dementia or Alzheimer's disease (AD). METHODS: We selected a subgroup from the Duke Established Populations for Epidemiologic Studies of the Elderly, a longitudinal study of community-representative persons aged 65-105 years living in 5 adjacent counties in North Carolina, and followed them for dementia (1986-1987 through June 2000). Information gathered during in-home interviews included sociodemographic characteristics, health status, health service use, and vitamin use. Diagnosis of dementia and AD was based on evaluations using the clinical and neuropsychological batteries of the Consortium to Establish a Registry for Alzheimer's Disease, with final determination by consensus agreement of specialists using Diagnostic and Statistical Manual of Mental Disorders, third revision, and National Institute for Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders criteria. RESULTS: Of 616 persons initially dementia-free (mean age 73 y; 62% female; 62% African American), 141 developed dementia, of whom 93 developed AD. Increased age and mobility problems were risk factors for dementia (only age for AD), while an increased number of outpatient visits reduced the likelihood of developing dementia. Neither use of any vitamins C and/or E (used by 8% of subjects at baseline) nor high-dose use reduced the time to dementia or AD. CONCLUSIONS: In this community in the southeastern US where vitamin supplement use is low, use of vitamins C and/or E did not delay the incidence of dementia or AD. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/16227448/Dementia_and_Alzheimer's_disease_in_community_dwelling_elders_taking_vitamin_C_and/or_vitamin_E_ L2 - http://journals.sagepub.com/doi/full/10.1345/aph.1G280?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -