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Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E.
Ann Pharmacother. 2005 Dec; 39(12):2009-14.AP

Abstract

BACKGROUND

Since increased oxidative stress may impair cognition and be a risk factor for dementia, there has been interest in determining whether use of antioxidants could protect against such events.

OBJECTIVE

To determine whether supplement use of vitamins C and/or E in a community-based sample of older African American and white individuals delayed incident dementia or Alzheimer's disease (AD).

METHODS

We selected a subgroup from the Duke Established Populations for Epidemiologic Studies of the Elderly, a longitudinal study of community-representative persons aged 65-105 years living in 5 adjacent counties in North Carolina, and followed them for dementia (1986-1987 through June 2000). Information gathered during in-home interviews included sociodemographic characteristics, health status, health service use, and vitamin use. Diagnosis of dementia and AD was based on evaluations using the clinical and neuropsychological batteries of the Consortium to Establish a Registry for Alzheimer's Disease, with final determination by consensus agreement of specialists using Diagnostic and Statistical Manual of Mental Disorders, third revision, and National Institute for Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders criteria.

RESULTS

Of 616 persons initially dementia-free (mean age 73 y; 62% female; 62% African American), 141 developed dementia, of whom 93 developed AD. Increased age and mobility problems were risk factors for dementia (only age for AD), while an increased number of outpatient visits reduced the likelihood of developing dementia. Neither use of any vitamins C and/or E (used by 8% of subjects at baseline) nor high-dose use reduced the time to dementia or AD.

CONCLUSIONS

In this community in the southeastern US where vitamin supplement use is low, use of vitamins C and/or E did not delay the incidence of dementia or AD.

Authors+Show Affiliations

Fillenbaum GG
Duke University Medical Center and Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Durham, NC 27710, USA. ggr@geri.duke.edu
Kuchibhatla MN
No affiliation info available
Hanlon JT
No affiliation info available
Artz MB
No affiliation info available
Pieper CF
No affiliation info available
Schmader KE
No affiliation info available
Dysken MW
No affiliation info available
Gray SL
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseAntioxidantsAscorbic AcidCohort StudiesData Interpretation, StatisticalDementiaFemaleHumansLongitudinal StudiesMaleNeuropsychological TestsNorth CarolinaOxidative StressProspective StudiesVitamin E

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16227448

Citation

Fillenbaum, Gerda G., et al. "Dementia and Alzheimer's Disease in Community-dwelling Elders Taking Vitamin C And/or Vitamin E." The Annals of Pharmacotherapy, vol. 39, no. 12, 2005, pp. 2009-14.
Fillenbaum GG, Kuchibhatla MN, Hanlon JT, et al. Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. Ann Pharmacother. 2005;39(12):2009-14.
Fillenbaum, G. G., Kuchibhatla, M. N., Hanlon, J. T., Artz, M. B., Pieper, C. F., Schmader, K. E., Dysken, M. W., & Gray, S. L. (2005). Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. The Annals of Pharmacotherapy, 39(12), 2009-14.
Fillenbaum GG, et al. Dementia and Alzheimer's Disease in Community-dwelling Elders Taking Vitamin C And/or Vitamin E. Ann Pharmacother. 2005;39(12):2009-14. PubMed PMID: 16227448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. AU - Fillenbaum,Gerda G, AU - Kuchibhatla,Maragatha N, AU - Hanlon,Joseph T, AU - Artz,Margaret B, AU - Pieper,Carl F, AU - Schmader,Kenneth E, AU - Dysken,Maurice W, AU - Gray,Shelly L, Y1 - 2005/10/14/ PY - 2005/10/18/pubmed PY - 2006/3/16/medline PY - 2005/10/18/entrez SP - 2009 EP - 14 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 39 IS - 12 N2 - BACKGROUND: Since increased oxidative stress may impair cognition and be a risk factor for dementia, there has been interest in determining whether use of antioxidants could protect against such events. OBJECTIVE: To determine whether supplement use of vitamins C and/or E in a community-based sample of older African American and white individuals delayed incident dementia or Alzheimer's disease (AD). METHODS: We selected a subgroup from the Duke Established Populations for Epidemiologic Studies of the Elderly, a longitudinal study of community-representative persons aged 65-105 years living in 5 adjacent counties in North Carolina, and followed them for dementia (1986-1987 through June 2000). Information gathered during in-home interviews included sociodemographic characteristics, health status, health service use, and vitamin use. Diagnosis of dementia and AD was based on evaluations using the clinical and neuropsychological batteries of the Consortium to Establish a Registry for Alzheimer's Disease, with final determination by consensus agreement of specialists using Diagnostic and Statistical Manual of Mental Disorders, third revision, and National Institute for Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders criteria. RESULTS: Of 616 persons initially dementia-free (mean age 73 y; 62% female; 62% African American), 141 developed dementia, of whom 93 developed AD. Increased age and mobility problems were risk factors for dementia (only age for AD), while an increased number of outpatient visits reduced the likelihood of developing dementia. Neither use of any vitamins C and/or E (used by 8% of subjects at baseline) nor high-dose use reduced the time to dementia or AD. CONCLUSIONS: In this community in the southeastern US where vitamin supplement use is low, use of vitamins C and/or E did not delay the incidence of dementia or AD. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/16227448/Dementia_and_Alzheimer's_disease_in_community_dwelling_elders_taking_vitamin_C_and/or_vitamin_E_ DB - PRIME DP - Unbound Medicine ER -