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Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients.
Int J Radiat Oncol Biol Phys. 2006 Jan 01; 64(1):210-7.IJ

Abstract

PURPOSE

To assess the outcomes and patterns of failure in solitary plasmacytoma (SP).

METHODS AND MATERIALS

The data from 258 patients with bone (n = 206) or extramedullary (n = 52) SP without evidence of multiple myeloma (MM) were collected. A histopathologic diagnosis was obtained for all patients. Most (n = 214) of the patients received radiotherapy (RT) alone; 34 received chemotherapy and RT, and 8 surgery alone. The median radiation dose was 40 Gy. The median follow-up was 56 months (range 7-245).

RESULTS

The median time to MM development was 21 months (range 2-135), with a 5-year probability of 45%. The 5-year overall survival, disease-free survival, and local control rate was 74%, 50%, and 86%, respectively. On multivariate analyses, the favorable factors were younger age and tumor size <4 cm for survival; younger age, extramedullary localization, and RT for disease-free survival; and small tumor and RT for local control. Bone localization was the only predictor of MM development. No dose-response relationship was found for doses >30 Gy, even for larger tumors.

CONCLUSION

Progression to MM remains the main problem. Patients with extramedullary SP had the best outcomes, especially when treated with moderate-dose RT. Chemotherapy and/or novel therapies should be investigated for bone or bulky extramedullary SP.

Authors+Show Affiliations

Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. mahmut.ozsahin@chuv.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16229966

Citation

Ozsahin, Mahmut, et al. "Outcomes and Patterns of Failure in Solitary Plasmacytoma: a Multicenter Rare Cancer Network Study of 258 Patients." International Journal of Radiation Oncology, Biology, Physics, vol. 64, no. 1, 2006, pp. 210-7.
Ozsahin M, Tsang RW, Poortmans P, et al. Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients. Int J Radiat Oncol Biol Phys. 2006;64(1):210-7.
Ozsahin, M., Tsang, R. W., Poortmans, P., Belkacémi, Y., Bolla, M., Dinçbas, F. O., Landmann, C., Castelain, B., Buijsen, J., Curschmann, J., Kadish, S. P., Kowalczyk, A., Anacak, Y., Hammer, J., Nguyen, T. D., Studer, G., Cooper, R., Sengöz, M., Scandolaro, L., & Zouhair, A. (2006). Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients. International Journal of Radiation Oncology, Biology, Physics, 64(1), 210-7.
Ozsahin M, et al. Outcomes and Patterns of Failure in Solitary Plasmacytoma: a Multicenter Rare Cancer Network Study of 258 Patients. Int J Radiat Oncol Biol Phys. 2006 Jan 1;64(1):210-7. PubMed PMID: 16229966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients. AU - Ozsahin,Mahmut, AU - Tsang,Richard W, AU - Poortmans,Philip, AU - Belkacémi,Yazid, AU - Bolla,Michel, AU - Dinçbas,Fazilet Oner, AU - Landmann,Christine, AU - Castelain,Bernard, AU - Buijsen,Jeroen, AU - Curschmann,Jürgen, AU - Kadish,Sidney P, AU - Kowalczyk,Anna, AU - Anacak,Yavuz, AU - Hammer,Josef, AU - Nguyen,Tan D, AU - Studer,Gabriela, AU - Cooper,Rachel, AU - Sengöz,Meriç, AU - Scandolaro,Luciano, AU - Zouhair,Abderrahim, Y1 - 2005/10/17/ PY - 2005/05/12/received PY - 2005/06/23/revised PY - 2005/06/24/accepted PY - 2005/10/19/pubmed PY - 2006/3/24/medline PY - 2005/10/19/entrez SP - 210 EP - 7 JF - International journal of radiation oncology, biology, physics JO - Int J Radiat Oncol Biol Phys VL - 64 IS - 1 N2 - PURPOSE: To assess the outcomes and patterns of failure in solitary plasmacytoma (SP). METHODS AND MATERIALS: The data from 258 patients with bone (n = 206) or extramedullary (n = 52) SP without evidence of multiple myeloma (MM) were collected. A histopathologic diagnosis was obtained for all patients. Most (n = 214) of the patients received radiotherapy (RT) alone; 34 received chemotherapy and RT, and 8 surgery alone. The median radiation dose was 40 Gy. The median follow-up was 56 months (range 7-245). RESULTS: The median time to MM development was 21 months (range 2-135), with a 5-year probability of 45%. The 5-year overall survival, disease-free survival, and local control rate was 74%, 50%, and 86%, respectively. On multivariate analyses, the favorable factors were younger age and tumor size <4 cm for survival; younger age, extramedullary localization, and RT for disease-free survival; and small tumor and RT for local control. Bone localization was the only predictor of MM development. No dose-response relationship was found for doses >30 Gy, even for larger tumors. CONCLUSION: Progression to MM remains the main problem. Patients with extramedullary SP had the best outcomes, especially when treated with moderate-dose RT. Chemotherapy and/or novel therapies should be investigated for bone or bulky extramedullary SP. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/16229966/Outcomes_and_patterns_of_failure_in_solitary_plasmacytoma:_a_multicenter_Rare_Cancer_Network_study_of_258_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(05)02223-6 DB - PRIME DP - Unbound Medicine ER -