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Muscle and plasma coenzyme Q10 concentration, aerobic power and exercise economy of healthy men in response to four weeks of supplementation.
J Sports Med Phys Fitness. 2005 Sep; 45(3):337-46.JS

Abstract

AIM

To investigate whether 4 weeks of oral supplementation with coenzyme Q10 (CoQ10) would increase its concentration in skeletal muscle, and affect aerobic power (VO2max) and oxygen consumption during submaximal exercise in healthy, physically active men.

METHODS

Six volunteers with an average (+/-SD) age of 29.7+/-7.2 years and VO2max of 39.4+/-8.5 mL.kg-1.min-1, participated in a single-blind trial. The experiment consisted of 4 2-week phases, in the order of placebo run-in, CoQ10 supplementation (150 mg daily), CoQ10 (150 mg) plus vitamin E (1,000 IU daily), and placebo wash-out. A three-stage cycle economy test (4 minutes at each of 50, 100, and 150 watts), followed by a VO2max test (25 watts increment every minute till exhaustion), were performed prior to the supplementation and at the end of each phase. Blood samples were taken pre and post each VO2max test, and biopsy samples were obtained from the vastus lateralis muscle pre and post the 4 weeks of CoQ10 supplementation.

RESULTS

The plasma CoQ10 concentration was significantly elevated by the supplementation (P<0.05), however, it did not vary significantly pre and post each exercise test (P>0.05). The muscle CoQ10 concentration, VO2max ventilatory threshold, exercise economy and oxygen deficit showed no significant changes in response to the supplementation.

CONCLUSION

It was speculated that the non-significant effects of supplementation in healthy, non CoQ10-deficient men could be due to either that the mitochondrial membrane is normally saturated with CoQ10, or that the selected exercise testing protocol and variables were not sensitive enough to detect the effects.

Authors+Show Affiliations

School of Exercise Science and Sport Management, Southern Cross University, Lismore, Australia. szhou@scu.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16230985

Citation

Zhou, S, et al. "Muscle and Plasma Coenzyme Q10 Concentration, Aerobic Power and Exercise Economy of Healthy Men in Response to Four Weeks of Supplementation." The Journal of Sports Medicine and Physical Fitness, vol. 45, no. 3, 2005, pp. 337-46.
Zhou S, Zhang Y, Davie A, et al. Muscle and plasma coenzyme Q10 concentration, aerobic power and exercise economy of healthy men in response to four weeks of supplementation. J Sports Med Phys Fitness. 2005;45(3):337-46.
Zhou, S., Zhang, Y., Davie, A., Marshall-Gradisnik, S., Hu, H., Wang, J., & Brushett, D. (2005). Muscle and plasma coenzyme Q10 concentration, aerobic power and exercise economy of healthy men in response to four weeks of supplementation. The Journal of Sports Medicine and Physical Fitness, 45(3), 337-46.
Zhou S, et al. Muscle and Plasma Coenzyme Q10 Concentration, Aerobic Power and Exercise Economy of Healthy Men in Response to Four Weeks of Supplementation. J Sports Med Phys Fitness. 2005;45(3):337-46. PubMed PMID: 16230985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscle and plasma coenzyme Q10 concentration, aerobic power and exercise economy of healthy men in response to four weeks of supplementation. AU - Zhou,S, AU - Zhang,Y, AU - Davie,A, AU - Marshall-Gradisnik,S, AU - Hu,H, AU - Wang,J, AU - Brushett,D, PY - 2005/10/19/pubmed PY - 2006/2/14/medline PY - 2005/10/19/entrez SP - 337 EP - 46 JF - The Journal of sports medicine and physical fitness JO - J Sports Med Phys Fitness VL - 45 IS - 3 N2 - AIM: To investigate whether 4 weeks of oral supplementation with coenzyme Q10 (CoQ10) would increase its concentration in skeletal muscle, and affect aerobic power (VO2max) and oxygen consumption during submaximal exercise in healthy, physically active men. METHODS: Six volunteers with an average (+/-SD) age of 29.7+/-7.2 years and VO2max of 39.4+/-8.5 mL.kg-1.min-1, participated in a single-blind trial. The experiment consisted of 4 2-week phases, in the order of placebo run-in, CoQ10 supplementation (150 mg daily), CoQ10 (150 mg) plus vitamin E (1,000 IU daily), and placebo wash-out. A three-stage cycle economy test (4 minutes at each of 50, 100, and 150 watts), followed by a VO2max test (25 watts increment every minute till exhaustion), were performed prior to the supplementation and at the end of each phase. Blood samples were taken pre and post each VO2max test, and biopsy samples were obtained from the vastus lateralis muscle pre and post the 4 weeks of CoQ10 supplementation. RESULTS: The plasma CoQ10 concentration was significantly elevated by the supplementation (P<0.05), however, it did not vary significantly pre and post each exercise test (P>0.05). The muscle CoQ10 concentration, VO2max ventilatory threshold, exercise economy and oxygen deficit showed no significant changes in response to the supplementation. CONCLUSION: It was speculated that the non-significant effects of supplementation in healthy, non CoQ10-deficient men could be due to either that the mitochondrial membrane is normally saturated with CoQ10, or that the selected exercise testing protocol and variables were not sensitive enough to detect the effects. SN - 0022-4707 UR - https://www.unboundmedicine.com/medline/citation/16230985/Muscle_and_plasma_coenzyme_Q10_concentration_aerobic_power_and_exercise_economy_of_healthy_men_in_response_to_four_weeks_of_supplementation_ L2 - https://medlineplus.gov/exerciseandphysicalfitness.html DB - PRIME DP - Unbound Medicine ER -