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Several anthropometric measurements and breast cancer risk: results of the E3N cohort study.
Int J Obes (Lond) 2006; 30(1):156-63IJ

Abstract

OBJECTIVE

To investigate the association between various anthropometric characteristics and breast cancer.

DESIGN

Longitudinal prospective cohort study. Follow-up between 1995 and 2000.

SUBJECTS

In total, 69 116 women (age: 45-70 years; mean follow-up: 3.6 years), 275 premenopausal and 860 postmenopausal incident invasive breast cancers.

MEASUREMENTS

Self-reported height, weight, breast, thorax, waist and hip circumferences and calculated body mass index (BMI) and waist-to-hip ratio (WHR) at baseline.

RESULTS

A slight increase in risk with increasing height was found. Weight, BMI, thorax and waist circumferences and WHR were negatively related to breast cancer risk among premenopausal women. The relationships became non significant after additional adjustment for BMI. An increased risk of premenopausal breast cancer with an android body shape (WHR>0.87) might possibly be confined to obese women. Among postmenopausal women, all anthropometric measurements of corpulence were positively associated with breast cancer risk but became non significant after additional adjustment for BMI. No difference in risk of postmenopausal breast cancer according to HRT use was observed.

CONCLUSION

The study confirmed that adiposity was negatively associated to premenopausal breast cancer risk and positively associated to postmenopausal breast cancer risk. Further studies will be needed to specify clearly the association between WHR and breast cancer risk, particularly before menopause.

Authors+Show Affiliations

Equipe Inserm-IGR Nutrition, Hormones, Cancer, Institut Gustave Roussy, Villejuif, France.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16231021

Citation

Tehard, B, and F Clavel-Chapelon. "Several Anthropometric Measurements and Breast Cancer Risk: Results of the E3N Cohort Study." International Journal of Obesity (2005), vol. 30, no. 1, 2006, pp. 156-63.
Tehard B, Clavel-Chapelon F. Several anthropometric measurements and breast cancer risk: results of the E3N cohort study. Int J Obes (Lond). 2006;30(1):156-63.
Tehard, B., & Clavel-Chapelon, F. (2006). Several anthropometric measurements and breast cancer risk: results of the E3N cohort study. International Journal of Obesity (2005), 30(1), pp. 156-63.
Tehard B, Clavel-Chapelon F. Several Anthropometric Measurements and Breast Cancer Risk: Results of the E3N Cohort Study. Int J Obes (Lond). 2006;30(1):156-63. PubMed PMID: 16231021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Several anthropometric measurements and breast cancer risk: results of the E3N cohort study. AU - Tehard,B, AU - Clavel-Chapelon,F, PY - 2005/10/19/pubmed PY - 2006/7/21/medline PY - 2005/10/19/entrez SP - 156 EP - 63 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 30 IS - 1 N2 - OBJECTIVE: To investigate the association between various anthropometric characteristics and breast cancer. DESIGN: Longitudinal prospective cohort study. Follow-up between 1995 and 2000. SUBJECTS: In total, 69 116 women (age: 45-70 years; mean follow-up: 3.6 years), 275 premenopausal and 860 postmenopausal incident invasive breast cancers. MEASUREMENTS: Self-reported height, weight, breast, thorax, waist and hip circumferences and calculated body mass index (BMI) and waist-to-hip ratio (WHR) at baseline. RESULTS: A slight increase in risk with increasing height was found. Weight, BMI, thorax and waist circumferences and WHR were negatively related to breast cancer risk among premenopausal women. The relationships became non significant after additional adjustment for BMI. An increased risk of premenopausal breast cancer with an android body shape (WHR>0.87) might possibly be confined to obese women. Among postmenopausal women, all anthropometric measurements of corpulence were positively associated with breast cancer risk but became non significant after additional adjustment for BMI. No difference in risk of postmenopausal breast cancer according to HRT use was observed. CONCLUSION: The study confirmed that adiposity was negatively associated to premenopausal breast cancer risk and positively associated to postmenopausal breast cancer risk. Further studies will be needed to specify clearly the association between WHR and breast cancer risk, particularly before menopause. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16231021/Several_anthropometric_measurements_and_breast_cancer_risk:_results_of_the_E3N_cohort_study_ L2 - http://dx.doi.org/10.1038/sj.ijo.0803133 DB - PRIME DP - Unbound Medicine ER -