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Low serum adiponectin levels in subjects born small for gestational age: impact on insulin sensitivity.
Int J Obes (Lond). 2006 Jan; 30(1):83-7.IJ

Abstract

OBJECTIVE

Increasing evidence point to the role of the adipose tissue on the insulin resistance associated with reduced fetal growth. Since adiponectin, exclusively produced by the adipose tissue, exerts an important insulin-sensitizing activity, it appears critical to investigate the effect of being born small for gestational age (SGA) on adiponectin production in adulthood and its relationship with insulin sensitivity.

SUBJECTS AND METHODS

Serum adiponectin concentrations were measured in 486 young adults born SGA, precisely selected on birth data, who were compared to 573 age-matched subjects born appropriate for gestational age (AGA). The relationship between serum adiponectin levels and insulin-resistance indices measured under OGTT were tested and compared between the two groups.

RESULTS

The SGA group demonstrated significantly reduced serum adiponectin levels than controls (12.6 +/- 6.9 vs 13.2 +/- 6.4 microg/ml, P = 0.02) and the difference remained significant when the key regulatory factors were taken into account (P = 0.008). In the AGA group, fasting I/G taken as an insulin-resistance index negatively correlated with serum adiponectin concentrations (P = 0.02), while the relationship followed a U-shape with increased fasting I/G ratio despite high concentrations of serum adiponectin in the SGA group (P = 0.12).

CONCLUSION

Subjects born SGA demonstrated significantly reduced serum adiponectin levels, which were not related to insulin-resistance indices in comparison to what observed in age-matched subjects born AGA. Although this defect in adiponectin production and in its insulin-sensitizing action remains to be elucidated at the molecular level, it strengthens the critical contribution of the adipose tissue in the metabolic complications associated with reduced fetal growth.

Authors+Show Affiliations

INSERM Unit 690, Hôpital R. Debré, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16231036

Citation

Jaquet, D, et al. "Low Serum Adiponectin Levels in Subjects Born Small for Gestational Age: Impact On Insulin Sensitivity." International Journal of Obesity (2005), vol. 30, no. 1, 2006, pp. 83-7.
Jaquet D, Deghmoun S, Chevenne D, et al. Low serum adiponectin levels in subjects born small for gestational age: impact on insulin sensitivity. Int J Obes (Lond). 2006;30(1):83-7.
Jaquet, D., Deghmoun, S., Chevenne, D., Czernichow, P., & Lévy-Marchal, C. (2006). Low serum adiponectin levels in subjects born small for gestational age: impact on insulin sensitivity. International Journal of Obesity (2005), 30(1), 83-7.
Jaquet D, et al. Low Serum Adiponectin Levels in Subjects Born Small for Gestational Age: Impact On Insulin Sensitivity. Int J Obes (Lond). 2006;30(1):83-7. PubMed PMID: 16231036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low serum adiponectin levels in subjects born small for gestational age: impact on insulin sensitivity. AU - Jaquet,D, AU - Deghmoun,S, AU - Chevenne,D, AU - Czernichow,P, AU - Lévy-Marchal,C, PY - 2005/10/19/pubmed PY - 2006/7/21/medline PY - 2005/10/19/entrez SP - 83 EP - 7 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 30 IS - 1 N2 - OBJECTIVE: Increasing evidence point to the role of the adipose tissue on the insulin resistance associated with reduced fetal growth. Since adiponectin, exclusively produced by the adipose tissue, exerts an important insulin-sensitizing activity, it appears critical to investigate the effect of being born small for gestational age (SGA) on adiponectin production in adulthood and its relationship with insulin sensitivity. SUBJECTS AND METHODS: Serum adiponectin concentrations were measured in 486 young adults born SGA, precisely selected on birth data, who were compared to 573 age-matched subjects born appropriate for gestational age (AGA). The relationship between serum adiponectin levels and insulin-resistance indices measured under OGTT were tested and compared between the two groups. RESULTS: The SGA group demonstrated significantly reduced serum adiponectin levels than controls (12.6 +/- 6.9 vs 13.2 +/- 6.4 microg/ml, P = 0.02) and the difference remained significant when the key regulatory factors were taken into account (P = 0.008). In the AGA group, fasting I/G taken as an insulin-resistance index negatively correlated with serum adiponectin concentrations (P = 0.02), while the relationship followed a U-shape with increased fasting I/G ratio despite high concentrations of serum adiponectin in the SGA group (P = 0.12). CONCLUSION: Subjects born SGA demonstrated significantly reduced serum adiponectin levels, which were not related to insulin-resistance indices in comparison to what observed in age-matched subjects born AGA. Although this defect in adiponectin production and in its insulin-sensitizing action remains to be elucidated at the molecular level, it strengthens the critical contribution of the adipose tissue in the metabolic complications associated with reduced fetal growth. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16231036/Low_serum_adiponectin_levels_in_subjects_born_small_for_gestational_age:_impact_on_insulin_sensitivity_ L2 - https://doi.org/10.1038/sj.ijo.0803106 DB - PRIME DP - Unbound Medicine ER -