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The effects of bone therapy on tibial bone loss in young women with anorexia nervosa.

Abstract

OBJECTIVE

Osteoporosis is recognized as a common medical complication of anorexia nervosa (AN). The purpose of the current study was to investigate the recovery mechanism of osteoporosis in AN and the effect of medical treatment on the skeletal system.

METHOD

We conducted a randomized placebo-controlled study of the effects of etidronate and calcium and vitamin D on bone loss in 41 outpatients with the restricting type of AN (AN-R). We measured the tibial speed of sound (SOS) before and after 3 months of treatment.

RESULTS

The bone mineral density (BMD) of the tibial SOS change in both the etidronate group and the calcium and vitamin D Group was significantly greater (p < .001) than in the control group. Urine-N-telopeptide cross-links of type I collagen (NTx) before and after treatment decreased significantly (p < .01) in the etidronate group.

CONCLUSION

These findings suggest that both etidronate and calcium and vitamin D are equally efficacious for reversing the degree of osteoporosis in patients with AN.

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  • Authors+Show Affiliations

    ,

    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima-City, Japan. ayana-n@m3.kufm.kagoshima-u.ac.jp

    , , , , ,

    Source

    MeSH

    Adult
    Anorexia Nervosa
    Bone Density Conservation Agents
    Calcium
    Etidronic Acid
    Female
    Humans
    Osteoporosis
    Tibia
    Vitamin D

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16231362

    Citation

    Nakahara, Toshihiro, et al. "The Effects of Bone Therapy On Tibial Bone Loss in Young Women With Anorexia Nervosa." The International Journal of Eating Disorders, vol. 39, no. 1, 2006, pp. 20-6.
    Nakahara T, Nagai N, Tanaka M, et al. The effects of bone therapy on tibial bone loss in young women with anorexia nervosa. Int J Eat Disord. 2006;39(1):20-6.
    Nakahara, T., Nagai, N., Tanaka, M., Muranaga, T., Kojima, S., Nozoe, S., & Naruo, T. (2006). The effects of bone therapy on tibial bone loss in young women with anorexia nervosa. The International Journal of Eating Disorders, 39(1), pp. 20-6.
    Nakahara T, et al. The Effects of Bone Therapy On Tibial Bone Loss in Young Women With Anorexia Nervosa. Int J Eat Disord. 2006;39(1):20-6. PubMed PMID: 16231362.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effects of bone therapy on tibial bone loss in young women with anorexia nervosa. AU - Nakahara,Toshihiro, AU - Nagai,Nobuatsu, AU - Tanaka,Muneki, AU - Muranaga,Tetsuro, AU - Kojima,Shinya, AU - Nozoe,Shin-ichi, AU - Naruo,Tetsuro, PY - 2005/10/19/pubmed PY - 2006/4/15/medline PY - 2005/10/19/entrez SP - 20 EP - 6 JF - The International journal of eating disorders JO - Int J Eat Disord VL - 39 IS - 1 N2 - OBJECTIVE: Osteoporosis is recognized as a common medical complication of anorexia nervosa (AN). The purpose of the current study was to investigate the recovery mechanism of osteoporosis in AN and the effect of medical treatment on the skeletal system. METHOD: We conducted a randomized placebo-controlled study of the effects of etidronate and calcium and vitamin D on bone loss in 41 outpatients with the restricting type of AN (AN-R). We measured the tibial speed of sound (SOS) before and after 3 months of treatment. RESULTS: The bone mineral density (BMD) of the tibial SOS change in both the etidronate group and the calcium and vitamin D Group was significantly greater (p < .001) than in the control group. Urine-N-telopeptide cross-links of type I collagen (NTx) before and after treatment decreased significantly (p < .01) in the etidronate group. CONCLUSION: These findings suggest that both etidronate and calcium and vitamin D are equally efficacious for reversing the degree of osteoporosis in patients with AN. SN - 0276-3478 UR - https://www.unboundmedicine.com/medline/citation/16231362/full_citation L2 - https://doi.org/10.1002/eat.20197 DB - PRIME DP - Unbound Medicine ER -