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Strikingly higher interleukin (IL)-1alpha, IL-1beta and soluble interleukin-1 receptor antagonist (sIL-1RA) but similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta and interferon IFN-gamma urine levels in healthy females compared to healthy males: protection against urinary tract injury?
Clin Exp Immunol 2005; 142(2):312-7CE

Abstract

The aim of this prospective study was to examine gender-related differences of cytokines in the plasma and urine of healthy individuals that might provide a clue concerning the lower rate of chronic renal diseases in females. Soluble interleukin-1 receptor antagonist (sIL-1RA), interleukin (IL)-1alpha, IL-1beta, IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta(2) and interferon (IFN)-gamma were determined using standard enzyme-linked immunosorbent assay (ELISA). Cytokine levels were determined in simultaneously obtained plasma and urine samples of 18 male and 28 female healthy members of our laboratory staff. Urine cytokine levels were studied three times at 1-month intervals. All individuals had a negative urine nitrite test and showed no symptoms of urinary tract infection (UTI). Plasma levels of all studied cytokines were similar in males and females (P = n.s.). However, females had significantly higher urine IL-1alpha (P < 0.0001; P < 0.0001; P < 0.0001) and sIL-1RA (P = 0.0001; P = 0.0003; P = 0.0002) than males at three and higher IL-1beta at one of the three investigations (P = 0.098; P = 0.003; P = 0.073). Urine levels of the other cytokines were similar in males and females. Higher urine levels of IL-1alpha, IL-1beta and sIL-1RA in females may result from stimulation of cells in the urinary tract. Increased sIL-1RA might block T lymphocyte activation. The elevated cytokines may play a role in the protection of the female urinary tract from certain renal diseases, such as pyelonephritis and other inflammatory and sclerotic kidney diseases.

Authors+Show Affiliations

Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany. Mahmoud.Sadeghi@med.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16232218

Citation

Sadeghi, M, et al. "Strikingly Higher Interleukin (IL)-1alpha, IL-1beta and Soluble Interleukin-1 Receptor Antagonist (sIL-1RA) but Similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, Tumour Necrosis Factor (TNF)-alpha, Transforming Growth Factor (TGF)-beta and Interferon IFN-gamma Urine Levels in Healthy Females Compared to Healthy Males: Protection Against Urinary Tract Injury?" Clinical and Experimental Immunology, vol. 142, no. 2, 2005, pp. 312-7.
Sadeghi M, Daniel V, Naujokat C, et al. Strikingly higher interleukin (IL)-1alpha, IL-1beta and soluble interleukin-1 receptor antagonist (sIL-1RA) but similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta and interferon IFN-gamma urine levels in healthy females compared to healthy males: protection against urinary tract injury? Clin Exp Immunol. 2005;142(2):312-7.
Sadeghi, M., Daniel, V., Naujokat, C., Weimer, R., & Opelz, G. (2005). Strikingly higher interleukin (IL)-1alpha, IL-1beta and soluble interleukin-1 receptor antagonist (sIL-1RA) but similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta and interferon IFN-gamma urine levels in healthy females compared to healthy males: protection against urinary tract injury? Clinical and Experimental Immunology, 142(2), pp. 312-7.
Sadeghi M, et al. Strikingly Higher Interleukin (IL)-1alpha, IL-1beta and Soluble Interleukin-1 Receptor Antagonist (sIL-1RA) but Similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, Tumour Necrosis Factor (TNF)-alpha, Transforming Growth Factor (TGF)-beta and Interferon IFN-gamma Urine Levels in Healthy Females Compared to Healthy Males: Protection Against Urinary Tract Injury. Clin Exp Immunol. 2005;142(2):312-7. PubMed PMID: 16232218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strikingly higher interleukin (IL)-1alpha, IL-1beta and soluble interleukin-1 receptor antagonist (sIL-1RA) but similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta and interferon IFN-gamma urine levels in healthy females compared to healthy males: protection against urinary tract injury? AU - Sadeghi,M, AU - Daniel,V, AU - Naujokat,C, AU - Weimer,R, AU - Opelz,G, PY - 2005/10/20/pubmed PY - 2005/12/15/medline PY - 2005/10/20/entrez SP - 312 EP - 7 JF - Clinical and experimental immunology JO - Clin. Exp. Immunol. VL - 142 IS - 2 N2 - The aim of this prospective study was to examine gender-related differences of cytokines in the plasma and urine of healthy individuals that might provide a clue concerning the lower rate of chronic renal diseases in females. Soluble interleukin-1 receptor antagonist (sIL-1RA), interleukin (IL)-1alpha, IL-1beta, IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta(2) and interferon (IFN)-gamma were determined using standard enzyme-linked immunosorbent assay (ELISA). Cytokine levels were determined in simultaneously obtained plasma and urine samples of 18 male and 28 female healthy members of our laboratory staff. Urine cytokine levels were studied three times at 1-month intervals. All individuals had a negative urine nitrite test and showed no symptoms of urinary tract infection (UTI). Plasma levels of all studied cytokines were similar in males and females (P = n.s.). However, females had significantly higher urine IL-1alpha (P < 0.0001; P < 0.0001; P < 0.0001) and sIL-1RA (P = 0.0001; P = 0.0003; P = 0.0002) than males at three and higher IL-1beta at one of the three investigations (P = 0.098; P = 0.003; P = 0.073). Urine levels of the other cytokines were similar in males and females. Higher urine levels of IL-1alpha, IL-1beta and sIL-1RA in females may result from stimulation of cells in the urinary tract. Increased sIL-1RA might block T lymphocyte activation. The elevated cytokines may play a role in the protection of the female urinary tract from certain renal diseases, such as pyelonephritis and other inflammatory and sclerotic kidney diseases. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/16232218/Strikingly_higher_interleukin__IL__1alpha_IL_1beta_and_soluble_interleukin_1_receptor_antagonist__sIL_1RA__but_similar_IL_2_sIL_2R_IL_3_IL_4_IL_6_sIL_6R_IL_10_tumour_necrosis_factor__TNF__alpha_transforming_growth_factor__TGF__beta_and_interferon_IFN_gamma_urine_levels_in_healthy_females_compared_to_healthy_males:_protection_against_urinary_tract_injury L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0009-9104&amp;date=2005&amp;volume=142&amp;issue=2&amp;spage=312 DB - PRIME DP - Unbound Medicine ER -