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Increased sensitivity to the acute effects of MDMA ("ecstasy") in female rats.
Physiol Behav 2005; 86(4):546-53PB

Abstract

Behavioral effects of +/-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are relatively well described in humans as well as in animals. However, little is known about gender differences to the effects of MDMA. The aim of our study was to evaluate gender differences in stimulant effects of MDMA (2.5, 5.0, and 10.0 mg/kg subcutaneously (s.c.)) in male and female Wistar rats. We have used three behavioral methods (activity cage, open field, and elevated plus-maze) each describing a different pattern of spontaneous behavior. In the activity cage, 30 min after the MDMA administration, horizontal and vertical locomotor activities were registered for a period of 3 min. In the open field test rats were placed into an arena 15 min after drug treatment and locomotor activity was registered for a period of 30 min. Finally, in the elevated plus-maze test, rats were given MDMA 30 min prior to measurements and subsequently they were tested in the maze for a period of 5 min. In our experiments we observed a dose-dependent locomotion-enhancing effect of MDMA both in male and female rats in both locomotor tests. Female rats were more sensitive to the locomotor-stimulating effect than males in both tests, suggesting higher sensitivity to the stimulatory effect of MDMA. Further on, MDMA increased thigmotaxis in female rats in the open field test and decreased "anxious-like" behavior in the elevated plus-maze in both genders. In conclusion, we observed higher sensitivity of females to the locomotor-stimulant effect of MDMA. Increased sensitivity of females to the behavioral effects of MDMA can be explained by increased reactivity of serotonergic and dopaminergic systems.

Authors+Show Affiliations

Laboratory of Biochemistry and Pathophysiology of the Brain, Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Czech Republic. palenicek@pcp.lf3.cuni.czNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16233904

Citation

Palenicek, T, et al. "Increased Sensitivity to the Acute Effects of MDMA ("ecstasy") in Female Rats." Physiology & Behavior, vol. 86, no. 4, 2005, pp. 546-53.
Palenicek T, Votava M, Bubenikova V, et al. Increased sensitivity to the acute effects of MDMA ("ecstasy") in female rats. Physiol Behav. 2005;86(4):546-53.
Palenicek, T., Votava, M., Bubenikova, V., & Horacek, J. (2005). Increased sensitivity to the acute effects of MDMA ("ecstasy") in female rats. Physiology & Behavior, 86(4), pp. 546-53.
Palenicek T, et al. Increased Sensitivity to the Acute Effects of MDMA ("ecstasy") in Female Rats. Physiol Behav. 2005 Nov 15;86(4):546-53. PubMed PMID: 16233904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased sensitivity to the acute effects of MDMA ("ecstasy") in female rats. AU - Palenicek,T, AU - Votava,M, AU - Bubenikova,V, AU - Horacek,J, Y1 - 2005/10/17/ PY - 2004/11/04/received PY - 2005/06/25/revised PY - 2005/08/08/accepted PY - 2005/10/20/pubmed PY - 2006/1/18/medline PY - 2005/10/20/entrez SP - 546 EP - 53 JF - Physiology & behavior JO - Physiol. Behav. VL - 86 IS - 4 N2 - Behavioral effects of +/-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are relatively well described in humans as well as in animals. However, little is known about gender differences to the effects of MDMA. The aim of our study was to evaluate gender differences in stimulant effects of MDMA (2.5, 5.0, and 10.0 mg/kg subcutaneously (s.c.)) in male and female Wistar rats. We have used three behavioral methods (activity cage, open field, and elevated plus-maze) each describing a different pattern of spontaneous behavior. In the activity cage, 30 min after the MDMA administration, horizontal and vertical locomotor activities were registered for a period of 3 min. In the open field test rats were placed into an arena 15 min after drug treatment and locomotor activity was registered for a period of 30 min. Finally, in the elevated plus-maze test, rats were given MDMA 30 min prior to measurements and subsequently they were tested in the maze for a period of 5 min. In our experiments we observed a dose-dependent locomotion-enhancing effect of MDMA both in male and female rats in both locomotor tests. Female rats were more sensitive to the locomotor-stimulating effect than males in both tests, suggesting higher sensitivity to the stimulatory effect of MDMA. Further on, MDMA increased thigmotaxis in female rats in the open field test and decreased "anxious-like" behavior in the elevated plus-maze in both genders. In conclusion, we observed higher sensitivity of females to the locomotor-stimulant effect of MDMA. Increased sensitivity of females to the behavioral effects of MDMA can be explained by increased reactivity of serotonergic and dopaminergic systems. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/16233904/Increased_sensitivity_to_the_acute_effects_of_MDMA__"ecstasy"__in_female_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(05)00353-7 DB - PRIME DP - Unbound Medicine ER -