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Agricultural pesticide use and risk of glioma in Nebraska, United States.
Occup Environ Med. 2005 Nov; 62(11):786-92.OE

Abstract

BACKGROUND

To evaluate the risk of the adult glioma associated with farming and agricultural pesticide use, the authors conducted a population based case control study in eastern Nebraska.

METHODS

Telephone interviews were conducted with men and women diagnosed with gliomas (n = 251) between 1988 and 1993 and controls (n = 498) randomly selected from the same geographical area. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) for farming and for use of individual and chemical classes of insecticides and herbicides, including pesticides classified as nitrosatable (able to form N-nitroso compounds upon reaction with nitrite). Non-farmers were used as the reference category for all analyses.

RESULTS

Among men, ever living or working on a farm and duration of farming were associated with significantly increased risks of glioma (> or =55 years on a farm OR = 3.9, 95% CI 1.8 to 8.6); however, positive findings were limited to proxy respondents. Among women, there were no positive associations with farming activities among self or proxy respondents. Specific pesticide families and individual pesticides were associated with significantly increased risks among male farmers; however, most of the positive associations were limited to proxy respondents. For two herbicides and three insecticides, use was positively associated with risk among both self and proxy respondents. Based on a small number of exposed cases, ORs were significantly increased for the herbicides metribuzin (OR = 3.4, 95% CI 1.2 to 9.7) and paraquat (OR = 11.1, 95% CI 1.2 to 101), and for the insecticides bufencarb (OR = 18.9, 95% CI 1.9 to 187), chlorpyrifos (OR = 22.6, 95% CI 2.7 to 191), and coumaphos (OR = 5.9, 95% CI 1.1 to 32).

CONCLUSION

The authors found significant associations between some specific agricultural pesticide exposures and the risk of glioma among male farmers but not among female farmers in Nebraska; however, most of the positive associations were limited to proxy respondents. These findings warrant further evaluation in prospective cohort studies where issues of recall bias are not a concern.

Authors+Show Affiliations

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16234405

Citation

Lee, W J., et al. "Agricultural Pesticide Use and Risk of Glioma in Nebraska, United States." Occupational and Environmental Medicine, vol. 62, no. 11, 2005, pp. 786-92.
Lee WJ, Colt JS, Heineman EF, et al. Agricultural pesticide use and risk of glioma in Nebraska, United States. Occup Environ Med. 2005;62(11):786-92.
Lee, W. J., Colt, J. S., Heineman, E. F., McComb, R., Weisenburger, D. D., Lijinsky, W., & Ward, M. H. (2005). Agricultural pesticide use and risk of glioma in Nebraska, United States. Occupational and Environmental Medicine, 62(11), 786-92.
Lee WJ, et al. Agricultural Pesticide Use and Risk of Glioma in Nebraska, United States. Occup Environ Med. 2005;62(11):786-92. PubMed PMID: 16234405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Agricultural pesticide use and risk of glioma in Nebraska, United States. AU - Lee,W J, AU - Colt,J S, AU - Heineman,E F, AU - McComb,R, AU - Weisenburger,D D, AU - Lijinsky,W, AU - Ward,M H, PY - 2005/10/20/pubmed PY - 2005/11/16/medline PY - 2005/10/20/entrez SP - 786 EP - 92 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 62 IS - 11 N2 - BACKGROUND: To evaluate the risk of the adult glioma associated with farming and agricultural pesticide use, the authors conducted a population based case control study in eastern Nebraska. METHODS: Telephone interviews were conducted with men and women diagnosed with gliomas (n = 251) between 1988 and 1993 and controls (n = 498) randomly selected from the same geographical area. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) for farming and for use of individual and chemical classes of insecticides and herbicides, including pesticides classified as nitrosatable (able to form N-nitroso compounds upon reaction with nitrite). Non-farmers were used as the reference category for all analyses. RESULTS: Among men, ever living or working on a farm and duration of farming were associated with significantly increased risks of glioma (> or =55 years on a farm OR = 3.9, 95% CI 1.8 to 8.6); however, positive findings were limited to proxy respondents. Among women, there were no positive associations with farming activities among self or proxy respondents. Specific pesticide families and individual pesticides were associated with significantly increased risks among male farmers; however, most of the positive associations were limited to proxy respondents. For two herbicides and three insecticides, use was positively associated with risk among both self and proxy respondents. Based on a small number of exposed cases, ORs were significantly increased for the herbicides metribuzin (OR = 3.4, 95% CI 1.2 to 9.7) and paraquat (OR = 11.1, 95% CI 1.2 to 101), and for the insecticides bufencarb (OR = 18.9, 95% CI 1.9 to 187), chlorpyrifos (OR = 22.6, 95% CI 2.7 to 191), and coumaphos (OR = 5.9, 95% CI 1.1 to 32). CONCLUSION: The authors found significant associations between some specific agricultural pesticide exposures and the risk of glioma among male farmers but not among female farmers in Nebraska; however, most of the positive associations were limited to proxy respondents. These findings warrant further evaluation in prospective cohort studies where issues of recall bias are not a concern. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/16234405/Agricultural_pesticide_use_and_risk_of_glioma_in_Nebraska_United_States_ L2 - http://oem.bmj.com/cgi/pmidlookup?view=long&pmid=16234405 DB - PRIME DP - Unbound Medicine ER -