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Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects.
Eur J Clin Nutr. 2006 Mar; 60(3):325-33.EJ

Abstract

OBJECTIVE

To determine the impact of intake occasion (with or without a meal), and product fat level on the cholesterol-lowering efficacy of a plant sterol (PS)-enriched (3 g/day) single-dose yoghurt drink.

DESIGN

Double-blind, randomized, placebo-controlled, parallel study with a 4 weeks run-in and 4 weeks intervention period.

SETTING

Subjects recruited from the general community.

SUBJECTS

A total of 184 moderate hypercholesterolaemic subjects (81 men and 103 women) (age 57+/-2 years) completed the study.

INTERVENTIONS

The study product was a 100-g single-dose yoghurt drink with or without added PS in the form of PS esters. The subjects were randomly assigned to one of five 4-week treatments: (i) drink A (0.1% dairy fat, 2.2% total fat) with a meal, (ii) drink A without a meal, (iii) drink B (1.5% dairy fat, 3.3% total fat) with a meal, (iv) drink B without a meal and (v) placebo drink with a meal.

RESULTS

LDL-cholesterol (LDL-C) was significantly lowered when the single-dose drink was taken with a meal independent of its fat content (drink A: -9.5% (P<0.001, 95% CI: -13.8 to -5.2); drink B: -9.3% (P<0.001, 95% CI: -13.7 to -4.9)) as compared to placebo. When consumed without a meal, LDL-C was also significantly decreased (drink A: -5.1% (P<0.05, 95% CI: -9.4 to -0.8); drink B: -6.9% (P<0.01, 95% CI: -11.3 to -2.5) as compared to placebo, however the effect was significantly smaller as compared to the intake with a meal.

CONCLUSION

These results indicate that a PS-ester-enriched single-dose yoghurt drink effectively reduces LDL-C irrespective of the fat content of the product. A substantially larger decrease in serum cholesterol concentration was achieved when the single-dose drink was consumed with a meal emphasizing the importance of the intake occasion for optimal cholesterol-lowering efficacy.

SPONSORSHIP

Unilever Research and Development, Vlaardingen, The Netherlands.

Authors+Show Affiliations

Unilever Food and Health Research Institute, Vlaardingen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16234829

Citation

Doornbos, A M E., et al. "Intake Occasion Affects the Serum Cholesterol Lowering of a Plant Sterol-enriched Single-dose Yoghurt Drink in Mildly Hypercholesterolaemic Subjects." European Journal of Clinical Nutrition, vol. 60, no. 3, 2006, pp. 325-33.
Doornbos AM, Meynen EM, Duchateau GS, et al. Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects. Eur J Clin Nutr. 2006;60(3):325-33.
Doornbos, A. M., Meynen, E. M., Duchateau, G. S., van der Knaap, H. C., & Trautwein, E. A. (2006). Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects. European Journal of Clinical Nutrition, 60(3), 325-33.
Doornbos AM, et al. Intake Occasion Affects the Serum Cholesterol Lowering of a Plant Sterol-enriched Single-dose Yoghurt Drink in Mildly Hypercholesterolaemic Subjects. Eur J Clin Nutr. 2006;60(3):325-33. PubMed PMID: 16234829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects. AU - Doornbos,A M E, AU - Meynen,E M, AU - Duchateau,G S M J E, AU - van der Knaap,H C M, AU - Trautwein,E A, PY - 2005/10/20/pubmed PY - 2006/7/25/medline PY - 2005/10/20/entrez SP - 325 EP - 33 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 3 N2 - OBJECTIVE: To determine the impact of intake occasion (with or without a meal), and product fat level on the cholesterol-lowering efficacy of a plant sterol (PS)-enriched (3 g/day) single-dose yoghurt drink. DESIGN: Double-blind, randomized, placebo-controlled, parallel study with a 4 weeks run-in and 4 weeks intervention period. SETTING: Subjects recruited from the general community. SUBJECTS: A total of 184 moderate hypercholesterolaemic subjects (81 men and 103 women) (age 57+/-2 years) completed the study. INTERVENTIONS: The study product was a 100-g single-dose yoghurt drink with or without added PS in the form of PS esters. The subjects were randomly assigned to one of five 4-week treatments: (i) drink A (0.1% dairy fat, 2.2% total fat) with a meal, (ii) drink A without a meal, (iii) drink B (1.5% dairy fat, 3.3% total fat) with a meal, (iv) drink B without a meal and (v) placebo drink with a meal. RESULTS: LDL-cholesterol (LDL-C) was significantly lowered when the single-dose drink was taken with a meal independent of its fat content (drink A: -9.5% (P<0.001, 95% CI: -13.8 to -5.2); drink B: -9.3% (P<0.001, 95% CI: -13.7 to -4.9)) as compared to placebo. When consumed without a meal, LDL-C was also significantly decreased (drink A: -5.1% (P<0.05, 95% CI: -9.4 to -0.8); drink B: -6.9% (P<0.01, 95% CI: -11.3 to -2.5) as compared to placebo, however the effect was significantly smaller as compared to the intake with a meal. CONCLUSION: These results indicate that a PS-ester-enriched single-dose yoghurt drink effectively reduces LDL-C irrespective of the fat content of the product. A substantially larger decrease in serum cholesterol concentration was achieved when the single-dose drink was consumed with a meal emphasizing the importance of the intake occasion for optimal cholesterol-lowering efficacy. SPONSORSHIP: Unilever Research and Development, Vlaardingen, The Netherlands. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16234829/Intake_occasion_affects_the_serum_cholesterol_lowering_of_a_plant_sterol_enriched_single_dose_yoghurt_drink_in_mildly_hypercholesterolaemic_subjects_ DB - PRIME DP - Unbound Medicine ER -