Tags

Type your tag names separated by a space and hit enter

Role of visceral proteins in detecting malnutrition in the elderly.
Eur J Clin Nutr 2006; 60(2):203-9EJ

Abstract

OBJECTIVE

In the clinical practice, visceral proteins are used as indirect markers of protein energy malnutrition (PEM), but their reliability could be reduced with advancing age. The aim of this work is to investigate the reliability of albumin, prealbumin, retinol-binding protein (RBP) and transferrin in evaluating nutritional status in old patients and their relationship with fat-free mass (FFM).

DESIGN

Cross-sectional study.

SETTING

Padua, Italy.

SUBJECTS

In 44 underweight (body mass index < 20 kg/m(2)) (66-97 years) and 69 normal weight or overweight elderly subjects (62-98 years), albumin, prealbumin, transferrin and RBP were determined in the plasma. Body composition and particularly FFM was obtained by dual X-ray absorptiometry. FFM was also expressed as FFM index (FFMI) calculated as FFM divided by height squared. Subjects affected by acute illnesses and inflammatory states were excluded.

RESULTS

Albumin, prealbumin and RBP mean values were significantly lower in underweight subjects. No differences between two groups were found for transferrin. Albumin prealbumin and RBP resulted under the normal range in 55, 25 and 54% of underweight subjects, respectively. Transferrin's values were low in about 40% of underweight and normal weight subjects, respectively. In all subjects, FFMI shows a significant correlation with albumin (r: 0.52), prealbumin (r: 0.64) and RBP (r: 0.57). No correlation between FFMI and transferrin was found.

CONCLUSIONS

Visceral proteins, except for transferrin, seem to be useful indexes in detecting malnutrition in the elderly; low values still in the normal range should also be carefully evaluated because they could suggest a poor nutritional status.

Authors+Show Affiliations

Department of Medical and Surgical Sciences, Division of Geriatrics, University of Padua, Italy. giuseppe.sergi@unipd.it

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16234837

Citation

Sergi, G, et al. "Role of Visceral Proteins in Detecting Malnutrition in the Elderly." European Journal of Clinical Nutrition, vol. 60, no. 2, 2006, pp. 203-9.
Sergi G, Coin A, Enzi G, et al. Role of visceral proteins in detecting malnutrition in the elderly. Eur J Clin Nutr. 2006;60(2):203-9.
Sergi, G., Coin, A., Enzi, G., Volpato, S., Inelmen, E. M., Buttarello, M., ... Bonometto, P. (2006). Role of visceral proteins in detecting malnutrition in the elderly. European Journal of Clinical Nutrition, 60(2), pp. 203-9.
Sergi G, et al. Role of Visceral Proteins in Detecting Malnutrition in the Elderly. Eur J Clin Nutr. 2006;60(2):203-9. PubMed PMID: 16234837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of visceral proteins in detecting malnutrition in the elderly. AU - Sergi,G, AU - Coin,A, AU - Enzi,G, AU - Volpato,S, AU - Inelmen,E M, AU - Buttarello,M, AU - Peloso,M, AU - Mulone,S, AU - Marin,S, AU - Bonometto,P, PY - 2005/10/20/pubmed PY - 2006/5/19/medline PY - 2005/10/20/entrez SP - 203 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 60 IS - 2 N2 - OBJECTIVE: In the clinical practice, visceral proteins are used as indirect markers of protein energy malnutrition (PEM), but their reliability could be reduced with advancing age. The aim of this work is to investigate the reliability of albumin, prealbumin, retinol-binding protein (RBP) and transferrin in evaluating nutritional status in old patients and their relationship with fat-free mass (FFM). DESIGN: Cross-sectional study. SETTING: Padua, Italy. SUBJECTS: In 44 underweight (body mass index < 20 kg/m(2)) (66-97 years) and 69 normal weight or overweight elderly subjects (62-98 years), albumin, prealbumin, transferrin and RBP were determined in the plasma. Body composition and particularly FFM was obtained by dual X-ray absorptiometry. FFM was also expressed as FFM index (FFMI) calculated as FFM divided by height squared. Subjects affected by acute illnesses and inflammatory states were excluded. RESULTS: Albumin, prealbumin and RBP mean values were significantly lower in underweight subjects. No differences between two groups were found for transferrin. Albumin prealbumin and RBP resulted under the normal range in 55, 25 and 54% of underweight subjects, respectively. Transferrin's values were low in about 40% of underweight and normal weight subjects, respectively. In all subjects, FFMI shows a significant correlation with albumin (r: 0.52), prealbumin (r: 0.64) and RBP (r: 0.57). No correlation between FFMI and transferrin was found. CONCLUSIONS: Visceral proteins, except for transferrin, seem to be useful indexes in detecting malnutrition in the elderly; low values still in the normal range should also be carefully evaluated because they could suggest a poor nutritional status. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16234837/Role_of_visceral_proteins_in_detecting_malnutrition_in_the_elderly_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602289 DB - PRIME DP - Unbound Medicine ER -