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Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized.
J Infect Dis. 2005 Nov 15; 192(10):1686-93.JI

Abstract

BACKGROUND

The most severe sequela of measles virus infection is subacute sclerosing panencephalitis (SSPE), a fatal disease of the central nervous system that generally develops 7-10 years after infection. From 1989 through 1991, a resurgence of measles occurred in the United States, with 55,622 cases of measles reported. The purpose of the present study was to identify cases of SSPE that were associated with the resurgence of measles and to calculate the risk of developing SSPE.

METHODS

Brain tissue samples obtained from 11 patients with a presumptive diagnosis of SSPE were tested for the presence of measles virus RNA. Measles virus genotypes were determined by reverse-transcription polymerase chain reaction (RT-PCR) and by analysis of the sequences of the PCR products. A search of the literature was conducted to identify reports of cases of SSPE in persons residing in the United States who had measles during 1989-1991.

RESULTS

The measles virus sequences derived from brain tissue samples obtained from 11 patients with SSPE confirmed the diagnosis of SSPE. For 5 of the 11 patients with SSPE who had samples tested by RT-PCR and for 7 patients with SSPE who were identified in published case reports, it was determined that the development of SSPE was associated with the measles resurgence that occurred in the United States during 1989-1991. The estimated risk of developing SSPE was 10-fold higher than the previous estimate reported for the United States in 1982.

CONCLUSIONS

Vaccination against measles prevents more cases of SSPE than was originally estimated.

Authors+Show Affiliations

Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16235165

Citation

Bellini, William J., et al. "Subacute Sclerosing Panencephalitis: More Cases of This Fatal Disease Are Prevented By Measles Immunization Than Was Previously Recognized." The Journal of Infectious Diseases, vol. 192, no. 10, 2005, pp. 1686-93.
Bellini WJ, Rota JS, Lowe LE, et al. Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized. J Infect Dis. 2005;192(10):1686-93.
Bellini, W. J., Rota, J. S., Lowe, L. E., Katz, R. S., Dyken, P. R., Zaki, S. R., Shieh, W. J., & Rota, P. A. (2005). Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized. The Journal of Infectious Diseases, 192(10), 1686-93.
Bellini WJ, et al. Subacute Sclerosing Panencephalitis: More Cases of This Fatal Disease Are Prevented By Measles Immunization Than Was Previously Recognized. J Infect Dis. 2005 Nov 15;192(10):1686-93. PubMed PMID: 16235165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized. AU - Bellini,William J, AU - Rota,Jennifer S, AU - Lowe,Luis E, AU - Katz,Russell S, AU - Dyken,Paul R, AU - Zaki,Sherif R, AU - Shieh,Wun-Ju, AU - Rota,Paul A, Y1 - 2005/10/12/ PY - 2005/05/04/received PY - 2005/06/06/accepted PY - 2005/10/20/pubmed PY - 2006/2/1/medline PY - 2005/10/20/entrez SP - 1686 EP - 93 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 192 IS - 10 N2 - BACKGROUND: The most severe sequela of measles virus infection is subacute sclerosing panencephalitis (SSPE), a fatal disease of the central nervous system that generally develops 7-10 years after infection. From 1989 through 1991, a resurgence of measles occurred in the United States, with 55,622 cases of measles reported. The purpose of the present study was to identify cases of SSPE that were associated with the resurgence of measles and to calculate the risk of developing SSPE. METHODS: Brain tissue samples obtained from 11 patients with a presumptive diagnosis of SSPE were tested for the presence of measles virus RNA. Measles virus genotypes were determined by reverse-transcription polymerase chain reaction (RT-PCR) and by analysis of the sequences of the PCR products. A search of the literature was conducted to identify reports of cases of SSPE in persons residing in the United States who had measles during 1989-1991. RESULTS: The measles virus sequences derived from brain tissue samples obtained from 11 patients with SSPE confirmed the diagnosis of SSPE. For 5 of the 11 patients with SSPE who had samples tested by RT-PCR and for 7 patients with SSPE who were identified in published case reports, it was determined that the development of SSPE was associated with the measles resurgence that occurred in the United States during 1989-1991. The estimated risk of developing SSPE was 10-fold higher than the previous estimate reported for the United States in 1982. CONCLUSIONS: Vaccination against measles prevents more cases of SSPE than was originally estimated. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/16235165/full_citation L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/497169 DB - PRIME DP - Unbound Medicine ER -