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Long-term functional consequences of quinolinic acid striatal lesions and their alteration following an addition of a globus pallidus lesion assessed using pharmacological magnetic resonance imaging.
Exp Neurol. 2005 Dec; 196(2):244-53.EN

Abstract

The present study tested the hypothesis that lesion to the rat globus pallidus (GP) can "normalize" the functioning of the basal ganglia-thalamocortical circuits in striatal-lesioned rats by assessing the functional connectivity of these regions using functional magnetic resonance imaging (fMRI). Changes in brain activation following systemic administration of amphetamine were assessed in (1) rats sustaining a unilateral lesion to the striatum, (2) rats sustaining a combined striatal and pallidal lesion, and (3) control rats. Striatal-lesioned rats showed attenuated cortical activation following amphetamine administration and lower correlations between the responses to amphetamine in different brain regions compared to control rats. Although the addition of an excitotoxic GP lesion failed to prevent striatal lesion-induced attenuation of cortical activation by amphetamine, it was effective in "normalizing" the correlations between the responses to amphetamine in the different areas. These results suggest that, although the GP lesion is ineffective in correcting the global changes in activity caused by the striatal lesion, it may have the capacity to partially restore alterations in functional connectivity resulting from the striatal lesion. These results are further discussed in view of our previous demonstration that lesions to the GP can reverse several behavioral deficits produced by a striatal lesion.

Authors+Show Affiliations

Psychology Department, Tel Aviv University, Tel Aviv, Israel. ricardo@post.tau.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16236282

Citation

Tarrasch, Ricardo, et al. "Long-term Functional Consequences of Quinolinic Acid Striatal Lesions and Their Alteration Following an Addition of a Globus Pallidus Lesion Assessed Using Pharmacological Magnetic Resonance Imaging." Experimental Neurology, vol. 196, no. 2, 2005, pp. 244-53.
Tarrasch R, Goelman G, Joel D, et al. Long-term functional consequences of quinolinic acid striatal lesions and their alteration following an addition of a globus pallidus lesion assessed using pharmacological magnetic resonance imaging. Exp Neurol. 2005;196(2):244-53.
Tarrasch, R., Goelman, G., Joel, D., Daphna, J., & Weiner, I. (2005). Long-term functional consequences of quinolinic acid striatal lesions and their alteration following an addition of a globus pallidus lesion assessed using pharmacological magnetic resonance imaging. Experimental Neurology, 196(2), 244-53.
Tarrasch R, et al. Long-term Functional Consequences of Quinolinic Acid Striatal Lesions and Their Alteration Following an Addition of a Globus Pallidus Lesion Assessed Using Pharmacological Magnetic Resonance Imaging. Exp Neurol. 2005;196(2):244-53. PubMed PMID: 16236282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term functional consequences of quinolinic acid striatal lesions and their alteration following an addition of a globus pallidus lesion assessed using pharmacological magnetic resonance imaging. AU - Tarrasch,Ricardo, AU - Goelman,Gadi, AU - Joel,Daphna, AU - Daphna,Joel, AU - Weiner,Ina, Y1 - 2005/10/19/ PY - 2005/03/27/received PY - 2005/07/19/revised PY - 2005/07/26/accepted PY - 2005/10/21/pubmed PY - 2006/1/26/medline PY - 2005/10/21/entrez SP - 244 EP - 53 JF - Experimental neurology JO - Exp Neurol VL - 196 IS - 2 N2 - The present study tested the hypothesis that lesion to the rat globus pallidus (GP) can "normalize" the functioning of the basal ganglia-thalamocortical circuits in striatal-lesioned rats by assessing the functional connectivity of these regions using functional magnetic resonance imaging (fMRI). Changes in brain activation following systemic administration of amphetamine were assessed in (1) rats sustaining a unilateral lesion to the striatum, (2) rats sustaining a combined striatal and pallidal lesion, and (3) control rats. Striatal-lesioned rats showed attenuated cortical activation following amphetamine administration and lower correlations between the responses to amphetamine in different brain regions compared to control rats. Although the addition of an excitotoxic GP lesion failed to prevent striatal lesion-induced attenuation of cortical activation by amphetamine, it was effective in "normalizing" the correlations between the responses to amphetamine in the different areas. These results suggest that, although the GP lesion is ineffective in correcting the global changes in activity caused by the striatal lesion, it may have the capacity to partially restore alterations in functional connectivity resulting from the striatal lesion. These results are further discussed in view of our previous demonstration that lesions to the GP can reverse several behavioral deficits produced by a striatal lesion. SN - 0014-4886 UR - https://www.unboundmedicine.com/medline/citation/16236282/Long_term_functional_consequences_of_quinolinic_acid_striatal_lesions_and_their_alteration_following_an_addition_of_a_globus_pallidus_lesion_assessed_using_pharmacological_magnetic_resonance_imaging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(05)00265-7 DB - PRIME DP - Unbound Medicine ER -