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Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli.
Int J Med Microbiol. 2005 Oct; 295(6-7):383-404.IJ

Abstract

Molecular epidemiological analyses of extraintestinal pathogenic Escherichia coli (ExPEC), which are also called "uropathogenic E. coli" since they are the principle pathogens in urinary tract infection, involve structured observations of E. coli as they occur in the wild. Careful selection of subjects and use of appropriate methods for genotyping and statistical analysis are required for optimal results. Molecular epidemiological studies have helped to clarify the host-pathogen relationships, phylogenetic background, reservoirs, and transmission pathways of ExPEC, to assess potential vaccine candidates, and to delineate areas for further study. Ongoing discovery of new putative virulence factors (VFs), increasing awareness of the importance of VF expression and molecular variants of VFs, and growing appreciation of transmission as an important contributor to ExPEC infections provide abundant stimulus for future molecular epidemiological studies. Published by Elsevier GmbH.

Authors+Show Affiliations

Johnson JR
Mucosal and Vaccine Research Center, Infectious Diseases (111F), VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA. johns007@umn.edu
Russo TA
No affiliation info available

MeSH

Adhesins, Escherichia coliBacterial ToxinsDrug Resistance, BacterialEscherichia coliEscherichia coli InfectionsHumansLipopolysaccharidesMolecular EpidemiologyUrinary Tract InfectionsVirulence

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

16238015

Citation

Johnson, James R., and Thomas A. Russo. "Molecular Epidemiology of Extraintestinal Pathogenic (uropathogenic) Escherichia Coli." International Journal of Medical Microbiology : IJMM, vol. 295, no. 6-7, 2005, pp. 383-404.
Johnson JR, Russo TA. Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli. Int J Med Microbiol. 2005;295(6-7):383-404.
Johnson, J. R., & Russo, T. A. (2005). Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli. International Journal of Medical Microbiology : IJMM, 295(6-7), 383-404.
Johnson JR, Russo TA. Molecular Epidemiology of Extraintestinal Pathogenic (uropathogenic) Escherichia Coli. Int J Med Microbiol. 2005;295(6-7):383-404. PubMed PMID: 16238015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli. AU - Johnson,James R, AU - Russo,Thomas A, PY - 2005/10/22/pubmed PY - 2005/12/13/medline PY - 2005/10/22/entrez SP - 383 EP - 404 JF - International journal of medical microbiology : IJMM JO - Int J Med Microbiol VL - 295 IS - 6-7 N2 - Molecular epidemiological analyses of extraintestinal pathogenic Escherichia coli (ExPEC), which are also called "uropathogenic E. coli" since they are the principle pathogens in urinary tract infection, involve structured observations of E. coli as they occur in the wild. Careful selection of subjects and use of appropriate methods for genotyping and statistical analysis are required for optimal results. Molecular epidemiological studies have helped to clarify the host-pathogen relationships, phylogenetic background, reservoirs, and transmission pathways of ExPEC, to assess potential vaccine candidates, and to delineate areas for further study. Ongoing discovery of new putative virulence factors (VFs), increasing awareness of the importance of VF expression and molecular variants of VFs, and growing appreciation of transmission as an important contributor to ExPEC infections provide abundant stimulus for future molecular epidemiological studies. Published by Elsevier GmbH. SN - 1438-4221 UR - https://www.unboundmedicine.com/medline/citation/16238015/Molecular_epidemiology_of_extraintestinal_pathogenic__uropathogenic__Escherichia_coli_ DB - PRIME DP - Unbound Medicine ER -