Tags

Type your tag names separated by a space and hit enter

Clinical variables associated with glaucomatous injury in eyes with large optic disc cupping.
Ophthalmic Surg Lasers Imaging. 2005 Sep-Oct; 36(5):401-9.OS

Abstract

BACKGROUND AND OBJECTIVE

To characterize the range of retinal nerve fiber layer (RNFL) and standard automated perimetry damage in eyes with large vertical cup-disc ratio (VCDR).

PATIENTS AND METHODS

Complete examination, standard automated perimetry, scanning laser polarimetry with variable corneal compensation, and optical coherence tomography (OCT) of the RNFL and optic nerve head were performed. Large VCDR was defined as > or = 0.80 using stereoscopic disc examination and OCT optic nerve head analysis. Structural and functional characteristics were assessed separately in eyes with a disc area of less than 2 mm2, 2 to 2.5 mm2 and greater than 2.5 mm2.

RESULTS

Fifty-seven eyes of 57 subjects were enrolled. A broad range in mean deviation (2.0 to -32.8 dB) and mean RNFL thickness with OCT (24.3-100.4 microm) and scanning laser polarimetry with variable corneal compensation (24.0-61.7 microm) was identified. Predictors of standard automated perimetry severity using multiple linear regression were mean RNFL thickness using OCT (P = .001) and scanning laser polarimetry (P = .001), OCT-vertical cup diameter (P = .003), temporal, superior, nasal, inferior, temporal standard deviation (P = .03), and OCT-disc area (P = .04). Eyes with an OCT-disc area of less than 2 mm2 demonstrated significantly greater standard automated perimetry damage, RNFL loss using OCT and scanning laser polarimetry, and OCT-rim area (P = .002, .0007, .03, and < .0001, respectively) compared with eyes with a disc area of greater than 2.5 mm2.

CONCLUSIONS

Eyes with large VCDR have a wide range of RNFL atrophy and standard automated perimetry damage. Small optic discs are associated with more advanced glaucomatous injury.

Authors+Show Affiliations

Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16238039

Citation

Greenfield, David S., and Harmohina Bagga. "Clinical Variables Associated With Glaucomatous Injury in Eyes With Large Optic Disc Cupping." Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye, vol. 36, no. 5, 2005, pp. 401-9.
Greenfield DS, Bagga H. Clinical variables associated with glaucomatous injury in eyes with large optic disc cupping. Ophthalmic Surg Lasers Imaging. 2005;36(5):401-9.
Greenfield, D. S., & Bagga, H. (2005). Clinical variables associated with glaucomatous injury in eyes with large optic disc cupping. Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye, 36(5), 401-9.
Greenfield DS, Bagga H. Clinical Variables Associated With Glaucomatous Injury in Eyes With Large Optic Disc Cupping. Ophthalmic Surg Lasers Imaging. 2005 Sep-Oct;36(5):401-9. PubMed PMID: 16238039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical variables associated with glaucomatous injury in eyes with large optic disc cupping. AU - Greenfield,David S, AU - Bagga,Harmohina, PY - 2005/10/22/pubmed PY - 2005/11/11/medline PY - 2005/10/22/entrez SP - 401 EP - 9 JF - Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye JO - Ophthalmic Surg Lasers Imaging VL - 36 IS - 5 N2 - BACKGROUND AND OBJECTIVE: To characterize the range of retinal nerve fiber layer (RNFL) and standard automated perimetry damage in eyes with large vertical cup-disc ratio (VCDR). PATIENTS AND METHODS: Complete examination, standard automated perimetry, scanning laser polarimetry with variable corneal compensation, and optical coherence tomography (OCT) of the RNFL and optic nerve head were performed. Large VCDR was defined as > or = 0.80 using stereoscopic disc examination and OCT optic nerve head analysis. Structural and functional characteristics were assessed separately in eyes with a disc area of less than 2 mm2, 2 to 2.5 mm2 and greater than 2.5 mm2. RESULTS: Fifty-seven eyes of 57 subjects were enrolled. A broad range in mean deviation (2.0 to -32.8 dB) and mean RNFL thickness with OCT (24.3-100.4 microm) and scanning laser polarimetry with variable corneal compensation (24.0-61.7 microm) was identified. Predictors of standard automated perimetry severity using multiple linear regression were mean RNFL thickness using OCT (P = .001) and scanning laser polarimetry (P = .001), OCT-vertical cup diameter (P = .003), temporal, superior, nasal, inferior, temporal standard deviation (P = .03), and OCT-disc area (P = .04). Eyes with an OCT-disc area of less than 2 mm2 demonstrated significantly greater standard automated perimetry damage, RNFL loss using OCT and scanning laser polarimetry, and OCT-rim area (P = .002, .0007, .03, and < .0001, respectively) compared with eyes with a disc area of greater than 2.5 mm2. CONCLUSIONS: Eyes with large VCDR have a wide range of RNFL atrophy and standard automated perimetry damage. Small optic discs are associated with more advanced glaucomatous injury. SN - 1542-8877 UR - https://www.unboundmedicine.com/medline/citation/16238039/Clinical_variables_associated_with_glaucomatous_injury_in_eyes_with_large_optic_disc_cupping_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=16238039.ui DB - PRIME DP - Unbound Medicine ER -