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Adipocytokines and cancer.
Physiol Res 2006; 55(3):233-44PR

Abstract

Adipose tissue-produced hormones significantly affect the metabolism of lipids and carbohydrates as well as numerous other processes in human body. It is generally accepted that endocrine dysfunction of adipose tissue may represent one of the causal links between obesity and insulin resistance/diabetes. Epidemiological studies underlined that obesity represents a significant risk factor for the development of cancer, although the exact mechanism of this relationship remains to be determined. Multiple recent studies have indicated that some of adipose tissue-derived hormones may significantly influence the growth and proliferation of tumorous stroma and malignant cells within. Here we review current knowledge about possible relationship of leptin and adiponectin to the etiopathogenesis of different malignant tumors. Most of the studies indicated that while leptin may potentiate the growth of cancer cells in vitro, adiponectin appears to have an opposite effect. Further studies are necessary to decide whether obesity-induced endocrine dysfunction of adipose tissue can directly influence carcinogenesis in different tissues and organs.

Authors+Show Affiliations

Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 00 Prague 2, Czech Republic. mhalu@lf1.cuni.czNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16238454

Citation

Housa, D, et al. "Adipocytokines and Cancer." Physiological Research, vol. 55, no. 3, 2006, pp. 233-44.
Housa D, Housová J, Vernerová Z, et al. Adipocytokines and cancer. Physiol Res. 2006;55(3):233-44.
Housa, D., Housová, J., Vernerová, Z., & Haluzík, M. (2006). Adipocytokines and cancer. Physiological Research, 55(3), pp. 233-44.
Housa D, et al. Adipocytokines and Cancer. Physiol Res. 2006;55(3):233-44. PubMed PMID: 16238454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipocytokines and cancer. AU - Housa,D, AU - Housová,J, AU - Vernerová,Z, AU - Haluzík,M, Y1 - 2005/10/17/ PY - 2005/10/22/pubmed PY - 2006/9/23/medline PY - 2005/10/22/entrez SP - 233 EP - 44 JF - Physiological research JO - Physiol Res VL - 55 IS - 3 N2 - Adipose tissue-produced hormones significantly affect the metabolism of lipids and carbohydrates as well as numerous other processes in human body. It is generally accepted that endocrine dysfunction of adipose tissue may represent one of the causal links between obesity and insulin resistance/diabetes. Epidemiological studies underlined that obesity represents a significant risk factor for the development of cancer, although the exact mechanism of this relationship remains to be determined. Multiple recent studies have indicated that some of adipose tissue-derived hormones may significantly influence the growth and proliferation of tumorous stroma and malignant cells within. Here we review current knowledge about possible relationship of leptin and adiponectin to the etiopathogenesis of different malignant tumors. Most of the studies indicated that while leptin may potentiate the growth of cancer cells in vitro, adiponectin appears to have an opposite effect. Further studies are necessary to decide whether obesity-induced endocrine dysfunction of adipose tissue can directly influence carcinogenesis in different tissues and organs. SN - 0862-8408 UR - https://www.unboundmedicine.com/medline/citation/16238454/full_citation L2 - http://www.biomed.cas.cz/physiolres/pdf/55/55_233.pdf DB - PRIME DP - Unbound Medicine ER -