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Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study.
Clin Exp Allergy. 2005 Oct; 35(10):1272-8.CE

Abstract

BACKGROUND

Growing up on a farm and an anthroposophic lifestyle are associated with a lower prevalence of allergic diseases in childhood. This might be related to increased inhalatory exposure to microbial agents.

OBJECTIVE

To assess the association between microbial agents in house dust and atopic wheeze in farm children, Steiner school children and reference children.

METHODS

Levels of bacterial endotoxin, fungal beta(1,3)-glucans and fungal extracellular polysaccharides (EPS) in mattress and living room floor dust were measured in a population of 270 atopic (=Phadiatop-positive) children with self-reported wheezing, including 168 current atopic wheezers, and 441 non-atopic, non-symptomatic controls. These children were selected from a cross-sectional study in five European countries.

RESULTS

In the study population as a whole, average levels of mattress dust endotoxin, EPS and glucans were slightly (1.1-1.2-fold; P<0.10) higher in control children than in atopic wheezers. Atopic wheeze was related to mattress levels of endotoxin, EPS and glucans in farm and farm-reference children. However, when adjusting for group (farm vs. farm-reference children), the associations became non-significant whereas the group effect remained. No associations between atopic wheeze and microbial agents were observed in Steiner and Steiner-reference children. For current atopic wheeze, the farm effect became non-significant after adjustment for microbial agent levels.

CONCLUSION

Not only bacterial endotoxin but also mould components might offer some protection against atopic wheeze in children. However, the protective effect of being raised on a farm was largely unexplained by the mattress microbial agent levels measured in this study.

Authors+Show Affiliations

Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands, and Children's Hospital, Salzburg, Austria. d.schram@iras.uu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16238785

Citation

Schram-Bijkerk, D, et al. "Bacterial and Fungal Agents in House Dust and Wheeze in Children: the PARSIFAL Study." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 35, no. 10, 2005, pp. 1272-8.
Schram-Bijkerk D, Doekes G, Douwes J, et al. Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study. Clin Exp Allergy. 2005;35(10):1272-8.
Schram-Bijkerk, D., Doekes, G., Douwes, J., Boeve, M., Riedler, J., Ublagger, E., von Mutius, E., Benz, M. R., Pershagen, G., van Hage, M., Scheynius, A., Braun-Fahrländer, C., Waser, M., & Brunekreef, B. (2005). Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 35(10), 1272-8.
Schram-Bijkerk D, et al. Bacterial and Fungal Agents in House Dust and Wheeze in Children: the PARSIFAL Study. Clin Exp Allergy. 2005;35(10):1272-8. PubMed PMID: 16238785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bacterial and fungal agents in house dust and wheeze in children: the PARSIFAL study. AU - Schram-Bijkerk,D, AU - Doekes,G, AU - Douwes,J, AU - Boeve,M, AU - Riedler,J, AU - Ublagger,E, AU - von Mutius,E, AU - Benz,M R, AU - Pershagen,G, AU - van Hage,M, AU - Scheynius,A, AU - Braun-Fahrländer,C, AU - Waser,M, AU - Brunekreef,B, AU - ,, PY - 2005/10/22/pubmed PY - 2006/2/10/medline PY - 2005/10/22/entrez SP - 1272 EP - 8 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 35 IS - 10 N2 - BACKGROUND: Growing up on a farm and an anthroposophic lifestyle are associated with a lower prevalence of allergic diseases in childhood. This might be related to increased inhalatory exposure to microbial agents. OBJECTIVE: To assess the association between microbial agents in house dust and atopic wheeze in farm children, Steiner school children and reference children. METHODS: Levels of bacterial endotoxin, fungal beta(1,3)-glucans and fungal extracellular polysaccharides (EPS) in mattress and living room floor dust were measured in a population of 270 atopic (=Phadiatop-positive) children with self-reported wheezing, including 168 current atopic wheezers, and 441 non-atopic, non-symptomatic controls. These children were selected from a cross-sectional study in five European countries. RESULTS: In the study population as a whole, average levels of mattress dust endotoxin, EPS and glucans were slightly (1.1-1.2-fold; P<0.10) higher in control children than in atopic wheezers. Atopic wheeze was related to mattress levels of endotoxin, EPS and glucans in farm and farm-reference children. However, when adjusting for group (farm vs. farm-reference children), the associations became non-significant whereas the group effect remained. No associations between atopic wheeze and microbial agents were observed in Steiner and Steiner-reference children. For current atopic wheeze, the farm effect became non-significant after adjustment for microbial agent levels. CONCLUSION: Not only bacterial endotoxin but also mould components might offer some protection against atopic wheeze in children. However, the protective effect of being raised on a farm was largely unexplained by the mattress microbial agent levels measured in this study. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/16238785/Bacterial_and_fungal_agents_in_house_dust_and_wheeze_in_children:_the_PARSIFAL_study_ L2 - https://doi.org/10.1111/j.1365-2222.2005.02339.x DB - PRIME DP - Unbound Medicine ER -