Tags

Type your tag names separated by a space and hit enter

Expression of CXCR4 is associated with axillary lymph node status in patients with early breast cancer.
Breast. 2006 Aug; 15(4):533-9.B

Abstract

Recent studies have discovered that CXCR4 is associated with tumor metastasis. It is worth understanding the association between CXCR4 expression and axillary lymph node involvement in early breast cancer. Eighty-five patients with early breast cancers were divided into three groups based on their axillary lymph node status. CXCR4 expression was assessed by immunohistochemistry in all cases and its correlation with axillary lymph node involvement was evaluated. There was a significant difference in nuclear CXCR4 expression among these three groups and high nuclear expression of CXCR4 was associated with cases with no lymph node involvement. However, high cytoplasmic expression of CXCR4 was associated with patients who developed high-level axillary lymph node involvement. In conclusion, the different staining locations of CXCR4 have varying biological significance for the metastatic potential of axillary lymph nodes. In particular, it provided information that high cytoplasmic expression of CXCR4 was related to axillary internodal metastasis, and adjuvant radio-chemotherapy was suggested.

Authors+Show Affiliations

Department of Pathology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16239110

Citation

Su, Y-C, et al. "Expression of CXCR4 Is Associated With Axillary Lymph Node Status in Patients With Early Breast Cancer." Breast (Edinburgh, Scotland), vol. 15, no. 4, 2006, pp. 533-9.
Su YC, Wu MT, Huang CJ, et al. Expression of CXCR4 is associated with axillary lymph node status in patients with early breast cancer. Breast. 2006;15(4):533-9.
Su, Y. C., Wu, M. T., Huang, C. J., Hou, M. F., Yang, S. F., & Chai, C. Y. (2006). Expression of CXCR4 is associated with axillary lymph node status in patients with early breast cancer. Breast (Edinburgh, Scotland), 15(4), 533-9.
Su YC, et al. Expression of CXCR4 Is Associated With Axillary Lymph Node Status in Patients With Early Breast Cancer. Breast. 2006;15(4):533-9. PubMed PMID: 16239110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of CXCR4 is associated with axillary lymph node status in patients with early breast cancer. AU - Su,Y-C, AU - Wu,M-T, AU - Huang,C-J, AU - Hou,M-F, AU - Yang,S-F, AU - Chai,C-Y, Y1 - 2005/10/18/ PY - 2005/02/19/received PY - 2005/06/09/revised PY - 2005/08/12/accepted PY - 2005/10/22/pubmed PY - 2006/10/20/medline PY - 2005/10/22/entrez SP - 533 EP - 9 JF - Breast (Edinburgh, Scotland) JO - Breast VL - 15 IS - 4 N2 - Recent studies have discovered that CXCR4 is associated with tumor metastasis. It is worth understanding the association between CXCR4 expression and axillary lymph node involvement in early breast cancer. Eighty-five patients with early breast cancers were divided into three groups based on their axillary lymph node status. CXCR4 expression was assessed by immunohistochemistry in all cases and its correlation with axillary lymph node involvement was evaluated. There was a significant difference in nuclear CXCR4 expression among these three groups and high nuclear expression of CXCR4 was associated with cases with no lymph node involvement. However, high cytoplasmic expression of CXCR4 was associated with patients who developed high-level axillary lymph node involvement. In conclusion, the different staining locations of CXCR4 have varying biological significance for the metastatic potential of axillary lymph nodes. In particular, it provided information that high cytoplasmic expression of CXCR4 was related to axillary internodal metastasis, and adjuvant radio-chemotherapy was suggested. SN - 0960-9776 UR - https://www.unboundmedicine.com/medline/citation/16239110/Expression_of_CXCR4_is_associated_with_axillary_lymph_node_status_in_patients_with_early_breast_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9776(05)00223-7 DB - PRIME DP - Unbound Medicine ER -