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Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease.
Lancet Neurol 2005; 4(11):705-11LN

Abstract

BACKGROUND

Physical activity may help maintain cognitive function and decrease dementia risk, but epidemiological findings remain controversial. The aim of our study was to investigate the association between leisure-time physical activity at midlife and the subsequent development of dementia and Alzheimer's disease (AD).

METHODS

Participants were randomly selected from the survivors of a population-based cohort previously surveyed in 1972, 1977, 1982, or 1987. 1449 persons (72.5%) age 65-79 years participated in the re-examination in 1998 (mean follow-up, 21 years). 117 persons had dementia and 76 had AD. Multiple logistic regression methods were used to analyse the association between leisure-time physical activity and dementia or AD.

FINDINGS

Leisure-time physical activity at midlife at least twice a week was associated with a reduced risk of dementia and AD (odds ratio [OR] 0.48 [95% CI 0.25-0.91] and 0.38 [0.17-0.85], respectively), even after adjustments for age, sex, education, follow-up time, locomotor disorders, APOE genotype, vascular disorders, smoking, and alcohol drinking. The associations were more pronounced among the APOE epsilon4 carriers.

INTERPRETATION

Leisure-time physical activity at midlife is associated with a decreased risk of dementia and AD later in life. Regular physical activity may reduce the risk or delay the onset of dementia and AD, especially among genetically susceptible individuals.

Authors+Show Affiliations

Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16239176

Citation

Rovio, Suvi, et al. "Leisure-time Physical Activity at Midlife and the Risk of Dementia and Alzheimer's Disease." The Lancet. Neurology, vol. 4, no. 11, 2005, pp. 705-11.
Rovio S, Kåreholt I, Helkala EL, et al. Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol. 2005;4(11):705-11.
Rovio, S., Kåreholt, I., Helkala, E. L., Viitanen, M., Winblad, B., Tuomilehto, J., ... Kivipelto, M. (2005). Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. The Lancet. Neurology, 4(11), pp. 705-11.
Rovio S, et al. Leisure-time Physical Activity at Midlife and the Risk of Dementia and Alzheimer's Disease. Lancet Neurol. 2005;4(11):705-11. PubMed PMID: 16239176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. AU - Rovio,Suvi, AU - Kåreholt,Ingemar, AU - Helkala,Eeva-Liisa, AU - Viitanen,Matti, AU - Winblad,Bengt, AU - Tuomilehto,Jaakko, AU - Soininen,Hilkka, AU - Nissinen,Aulikki, AU - Kivipelto,Miia, PY - 2005/10/22/pubmed PY - 2005/11/16/medline PY - 2005/10/22/entrez SP - 705 EP - 11 JF - The Lancet. Neurology JO - Lancet Neurol VL - 4 IS - 11 N2 - BACKGROUND: Physical activity may help maintain cognitive function and decrease dementia risk, but epidemiological findings remain controversial. The aim of our study was to investigate the association between leisure-time physical activity at midlife and the subsequent development of dementia and Alzheimer's disease (AD). METHODS: Participants were randomly selected from the survivors of a population-based cohort previously surveyed in 1972, 1977, 1982, or 1987. 1449 persons (72.5%) age 65-79 years participated in the re-examination in 1998 (mean follow-up, 21 years). 117 persons had dementia and 76 had AD. Multiple logistic regression methods were used to analyse the association between leisure-time physical activity and dementia or AD. FINDINGS: Leisure-time physical activity at midlife at least twice a week was associated with a reduced risk of dementia and AD (odds ratio [OR] 0.48 [95% CI 0.25-0.91] and 0.38 [0.17-0.85], respectively), even after adjustments for age, sex, education, follow-up time, locomotor disorders, APOE genotype, vascular disorders, smoking, and alcohol drinking. The associations were more pronounced among the APOE epsilon4 carriers. INTERPRETATION: Leisure-time physical activity at midlife is associated with a decreased risk of dementia and AD later in life. Regular physical activity may reduce the risk or delay the onset of dementia and AD, especially among genetically susceptible individuals. SN - 1474-4422 UR - https://www.unboundmedicine.com/medline/citation/16239176/Leisure_time_physical_activity_at_midlife_and_the_risk_of_dementia_and_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1474-4422(05)70198-8 DB - PRIME DP - Unbound Medicine ER -