Tags

Type your tag names separated by a space and hit enter

Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment.
Ann Neurol 2005; 58(5):730-5AN

Abstract

Multiple studies demonstrate that the brain in Alzheimer's disease (AD) contains extensive oxidative damage. Most of these studies used advanced-stage AD patients raising the question of whether oxidative damage is a late effect of neurodegeneration or precedes and contributes to the pathogenesis of AD. Here we describe F(2)-isoprostane (F(2)-IsoP) and F(4)-neuroprostane (F(4)-NP) levels in longitudinally followed, well documented autopsied normal control subjects and patients with amnestic mild cognitive impairment (MCI), and late-stage AD. Gas chromatography/negative ion chemical ionization/mass spectrometry was used to determine F(2)-IsoP and F(4)-NP levels. Significant increases in F(2)-IsoP levels were found in frontal, parietal and occipital lobes in MCI and late AD compared to controls but no significant differences were present between MCI and late AD. A significant increase in F(4)-NPs was present in parietal and occipital lobes in MCI compared to controls and a significant increase was present in these regions and hippocampus in late AD compared to controls. The only difference between MCI and late AD was significantly increased F(4)-NP in hippocampus in late AD. Our data indicate that lipid peroxidation is present in the brain of MCI patients and suggest that oxidative damage may play a role in the pathogenesis of AD.

Authors+Show Affiliations

Alzheimer's Disease Research Center, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA. wmark0@email.uky.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16240347

Citation

Markesbery, William R., et al. "Lipid Peroxidation Is an Early Event in the Brain in Amnestic Mild Cognitive Impairment." Annals of Neurology, vol. 58, no. 5, 2005, pp. 730-5.
Markesbery WR, Kryscio RJ, Lovell MA, et al. Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment. Ann Neurol. 2005;58(5):730-5.
Markesbery, W. R., Kryscio, R. J., Lovell, M. A., & Morrow, J. D. (2005). Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment. Annals of Neurology, 58(5), pp. 730-5.
Markesbery WR, et al. Lipid Peroxidation Is an Early Event in the Brain in Amnestic Mild Cognitive Impairment. Ann Neurol. 2005;58(5):730-5. PubMed PMID: 16240347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment. AU - Markesbery,William R, AU - Kryscio,Richard J, AU - Lovell,Mark A, AU - Morrow,Jason D, PY - 2005/10/22/pubmed PY - 2006/3/15/medline PY - 2005/10/22/entrez SP - 730 EP - 5 JF - Annals of neurology JO - Ann. Neurol. VL - 58 IS - 5 N2 - Multiple studies demonstrate that the brain in Alzheimer's disease (AD) contains extensive oxidative damage. Most of these studies used advanced-stage AD patients raising the question of whether oxidative damage is a late effect of neurodegeneration or precedes and contributes to the pathogenesis of AD. Here we describe F(2)-isoprostane (F(2)-IsoP) and F(4)-neuroprostane (F(4)-NP) levels in longitudinally followed, well documented autopsied normal control subjects and patients with amnestic mild cognitive impairment (MCI), and late-stage AD. Gas chromatography/negative ion chemical ionization/mass spectrometry was used to determine F(2)-IsoP and F(4)-NP levels. Significant increases in F(2)-IsoP levels were found in frontal, parietal and occipital lobes in MCI and late AD compared to controls but no significant differences were present between MCI and late AD. A significant increase in F(4)-NPs was present in parietal and occipital lobes in MCI compared to controls and a significant increase was present in these regions and hippocampus in late AD compared to controls. The only difference between MCI and late AD was significantly increased F(4)-NP in hippocampus in late AD. Our data indicate that lipid peroxidation is present in the brain of MCI patients and suggest that oxidative damage may play a role in the pathogenesis of AD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/16240347/Lipid_peroxidation_is_an_early_event_in_the_brain_in_amnestic_mild_cognitive_impairment_ L2 - https://doi.org/10.1002/ana.20629 DB - PRIME DP - Unbound Medicine ER -