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An outbreak of SHV-5 producing Klebsiella pneumoniae in a neonatal intensive care unit; meropenem failed to avoid fecal colonization.
New Microbiol. 2005 Jul; 28(3):231-6.NM

Abstract

An outbreak of extended-spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae (ESBL-Kp) in a neonatal intensive care unit prompted a prospective surveillance study between 12th September and 6th October 2003. Surveillance was carried out by obtaining stool samples twice a week. The DNA relatedness of the isolates was shown by random amplified polymorphic DNA comparison (ERIC-PCR). ESBL production was identified by clavulanate synergy, isoelectric focusing, PCR and sequence analysis. During the study period, 49 neonates were hospitalized in the neonatal intensive care unit (NICU). In the first 20-day period, five neonates were infected with ESBL-Kp. The first patient treated with third generation cephalosporin and the second patient treated with meropenem died. While all three infected survivors were clinically improving, the digestive tracts were being colonized by SHV-5 producing Klebsiella. In the next period of the study, five neonates were colonized by ESBL-Kp as well. Univariate comparison of risk factors between colonized and non-colonized neonates was not significant. A total of 24 colonally related ESBL-Kp have been recovered from clinical materials and stool samples. This study demonstrated that parenterally applied meropenem, though successful in treating the systemic illness, might fail to protect the digestive tract from colonization of ESBL-Kp.

Authors+Show Affiliations

Infeksiyon Hastaliklari & Klinik Mikrobiyoloji AD, Kocaeli Universitesi, Kocaeli, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16240695

Citation

Gundes, Sibel, et al. "An Outbreak of SHV-5 Producing Klebsiella Pneumoniae in a Neonatal Intensive Care Unit; Meropenem Failed to Avoid Fecal Colonization." The New Microbiologica, vol. 28, no. 3, 2005, pp. 231-6.
Gundes S, Arisoy AE, Kolayli F, et al. An outbreak of SHV-5 producing Klebsiella pneumoniae in a neonatal intensive care unit; meropenem failed to avoid fecal colonization. New Microbiol. 2005;28(3):231-6.
Gundes, S., Arisoy, A. E., Kolayli, F., Karaali, E., Turker, G., Sanic, A., Arisoy, E. S., & Vahaboglu, H. (2005). An outbreak of SHV-5 producing Klebsiella pneumoniae in a neonatal intensive care unit; meropenem failed to avoid fecal colonization. The New Microbiologica, 28(3), 231-6.
Gundes S, et al. An Outbreak of SHV-5 Producing Klebsiella Pneumoniae in a Neonatal Intensive Care Unit; Meropenem Failed to Avoid Fecal Colonization. New Microbiol. 2005;28(3):231-6. PubMed PMID: 16240695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An outbreak of SHV-5 producing Klebsiella pneumoniae in a neonatal intensive care unit; meropenem failed to avoid fecal colonization. AU - Gundes,Sibel, AU - Arisoy,Ayse Engin, AU - Kolayli,Fetiye, AU - Karaali,Emel, AU - Turker,Gulcan, AU - Sanic,Ahmet, AU - Arisoy,Emin Sami, AU - Vahaboglu,Haluk, PY - 2005/10/26/pubmed PY - 2005/11/10/medline PY - 2005/10/26/entrez SP - 231 EP - 6 JF - The new microbiologica JO - New Microbiol. VL - 28 IS - 3 N2 - An outbreak of extended-spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae (ESBL-Kp) in a neonatal intensive care unit prompted a prospective surveillance study between 12th September and 6th October 2003. Surveillance was carried out by obtaining stool samples twice a week. The DNA relatedness of the isolates was shown by random amplified polymorphic DNA comparison (ERIC-PCR). ESBL production was identified by clavulanate synergy, isoelectric focusing, PCR and sequence analysis. During the study period, 49 neonates were hospitalized in the neonatal intensive care unit (NICU). In the first 20-day period, five neonates were infected with ESBL-Kp. The first patient treated with third generation cephalosporin and the second patient treated with meropenem died. While all three infected survivors were clinically improving, the digestive tracts were being colonized by SHV-5 producing Klebsiella. In the next period of the study, five neonates were colonized by ESBL-Kp as well. Univariate comparison of risk factors between colonized and non-colonized neonates was not significant. A total of 24 colonally related ESBL-Kp have been recovered from clinical materials and stool samples. This study demonstrated that parenterally applied meropenem, though successful in treating the systemic illness, might fail to protect the digestive tract from colonization of ESBL-Kp. SN - 1121-7138 UR - https://www.unboundmedicine.com/medline/citation/16240695/An_outbreak_of_SHV_5_producing_Klebsiella_pneumoniae_in_a_neonatal_intensive_care_unit L2 - http://www.diseaseinfosearch.org/result/4006 DB - PRIME DP - Unbound Medicine ER -