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Novel micromachined silicon sensor for continuous glucose monitoring.
Biosens Bioelectron. 2005 Nov 15; 21(5):802-8.BB

Abstract

The construction and the application properties of a micro-machined silicon sensor for continuous glucose monitoring are presented. The sensor uses the conventional enzymatic conversion of glucose with amperometric detection of H(2)O(2). The innovation is the precise diffusion control of the analyte through a porous silicon membrane into a silicon etched cavity containing the immobilised enzyme. A variation of the number and size of the membrane pores allows to adjust the linear range of the sensor to the respective requirement. The sensor was tested in vitro as well as in clinical studies, being supplied with interstitial fluid. The cavity sensor was designed for a linear range between 0.5 and 20 mM. A signal response time of below 30 s and a signal stability exceeding 1 week is shown. By using a double cavity sensor falsification of the glucose signal by interfering substances can be compensated. In clinical trials the sensor measured continuously in interstitial fluid for up to 18 h without any signal drift and with good correlation to blood glucose reference values.

Authors+Show Affiliations

Piechotta G
Fraunhofer Institute for Silicon Technology, Fraunhoferstr. 1, 25524 Itzehoe, Germany. piechotta@isit.fhg.de
Albers J
No affiliation info available
Hintsche R
No affiliation info available

MeSH

Biosensing TechniquesBlood GlucoseBlood Glucose Self-MonitoringElectrochemistryEquipment DesignEquipment Failure AnalysisGlucose OxidaseHumansMicrofluidic Analytical TechniquesMiniaturizationReproducibility of ResultsSensitivity and Specificity

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16242621

Citation

Piechotta, G, et al. "Novel Micromachined Silicon Sensor for Continuous Glucose Monitoring." Biosensors & Bioelectronics, vol. 21, no. 5, 2005, pp. 802-8.
Piechotta G, Albers J, Hintsche R. Novel micromachined silicon sensor for continuous glucose monitoring. Biosens Bioelectron. 2005;21(5):802-8.
Piechotta, G., Albers, J., & Hintsche, R. (2005). Novel micromachined silicon sensor for continuous glucose monitoring. Biosensors & Bioelectronics, 21(5), 802-8.
Piechotta G, Albers J, Hintsche R. Novel Micromachined Silicon Sensor for Continuous Glucose Monitoring. Biosens Bioelectron. 2005 Nov 15;21(5):802-8. PubMed PMID: 16242621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel micromachined silicon sensor for continuous glucose monitoring. AU - Piechotta,G, AU - Albers,J, AU - Hintsche,R, PY - 2004/11/23/received PY - 2005/02/14/revised PY - 2005/02/15/accepted PY - 2005/10/26/pubmed PY - 2006/2/16/medline PY - 2005/10/26/entrez SP - 802 EP - 8 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 21 IS - 5 N2 - The construction and the application properties of a micro-machined silicon sensor for continuous glucose monitoring are presented. The sensor uses the conventional enzymatic conversion of glucose with amperometric detection of H(2)O(2). The innovation is the precise diffusion control of the analyte through a porous silicon membrane into a silicon etched cavity containing the immobilised enzyme. A variation of the number and size of the membrane pores allows to adjust the linear range of the sensor to the respective requirement. The sensor was tested in vitro as well as in clinical studies, being supplied with interstitial fluid. The cavity sensor was designed for a linear range between 0.5 and 20 mM. A signal response time of below 30 s and a signal stability exceeding 1 week is shown. By using a double cavity sensor falsification of the glucose signal by interfering substances can be compensated. In clinical trials the sensor measured continuously in interstitial fluid for up to 18 h without any signal drift and with good correlation to blood glucose reference values. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/16242621/Novel_micromachined_silicon_sensor_for_continuous_glucose_monitoring_ DB - PRIME DP - Unbound Medicine ER -