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Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats.
Neurobiol Dis. 2005 Nov; 20(2):360-71.ND

Abstract

In recent years, several lines of evidence have shown an increase in Parkinson's disease (PD) prevalence in rural environments where pesticides are widely used. Paraquat (PQ--herbicide) and maneb (MB--fungicide) are among the compounds suspected to induce neuronal degeneration and motor deficits characteristics of PD. Here, we investigated the effects of PQ and MB on dopaminergic (DA) neuron-glia cultures and in vivo in young adult rats. In vitro, PQ led to a loss of DA as compared to non-DA neurons and microglial activation in a dose-dependent manner. Addition of MB had no further effect nor did it lead to microglial activation when used alone. In vivo, 2-month old young adult rats were subjected to intraperitoneal injections of vehicle (n = 4), PQ alone (n = 8), or PQ in combination with MB (n = 8) twice a week for 4 weeks and were sacrificed the day following the last injection. Significant loss of nigral DA neurons was observed in both treatment groups, but a significant decrease in striatal DA fibers was not found. Microglial activation was seen in the nigra of rats subjected to PQ with or without MB. Behavioral analyses demonstrated a mixed pattern of motor impairments, which may have been related to early effects of nigral DA neuronal loss or systemic effects associated with MB exposure in addition to PQ. These results indicate that exposure to PQ with or without MB induces neurodegeneration which might occur via an early inflammatory response in young adult animals.

Authors+Show Affiliations

Centre de Recherche en Neurosciences, CHUL, RC-9800, 2705 Boulevard Laurier, Sainte-Foy, QC, Canada G1V 4G2. Francesca.Cicchetti@crchul.ulaval.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16242641

Citation

Cicchetti, Francesca, et al. "Systemic Exposure to Paraquat and Maneb Models Early Parkinson's Disease in Young Adult Rats." Neurobiology of Disease, vol. 20, no. 2, 2005, pp. 360-71.
Cicchetti F, Lapointe N, Roberge-Tremblay A, et al. Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats. Neurobiol Dis. 2005;20(2):360-71.
Cicchetti, F., Lapointe, N., Roberge-Tremblay, A., Saint-Pierre, M., Jimenez, L., Ficke, B. W., & Gross, R. E. (2005). Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats. Neurobiology of Disease, 20(2), 360-71.
Cicchetti F, et al. Systemic Exposure to Paraquat and Maneb Models Early Parkinson's Disease in Young Adult Rats. Neurobiol Dis. 2005;20(2):360-71. PubMed PMID: 16242641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systemic exposure to paraquat and maneb models early Parkinson's disease in young adult rats. AU - Cicchetti,Francesca, AU - Lapointe,Nicolas, AU - Roberge-Tremblay,Antoine, AU - Saint-Pierre,Martine, AU - Jimenez,Lincoln, AU - Ficke,Brooks W, AU - Gross,Robert E, PY - 2004/08/24/received PY - 2005/03/22/revised PY - 2005/03/22/accepted PY - 2005/10/26/pubmed PY - 2006/1/24/medline PY - 2005/10/26/entrez SP - 360 EP - 71 JF - Neurobiology of disease JO - Neurobiol Dis VL - 20 IS - 2 N2 - In recent years, several lines of evidence have shown an increase in Parkinson's disease (PD) prevalence in rural environments where pesticides are widely used. Paraquat (PQ--herbicide) and maneb (MB--fungicide) are among the compounds suspected to induce neuronal degeneration and motor deficits characteristics of PD. Here, we investigated the effects of PQ and MB on dopaminergic (DA) neuron-glia cultures and in vivo in young adult rats. In vitro, PQ led to a loss of DA as compared to non-DA neurons and microglial activation in a dose-dependent manner. Addition of MB had no further effect nor did it lead to microglial activation when used alone. In vivo, 2-month old young adult rats were subjected to intraperitoneal injections of vehicle (n = 4), PQ alone (n = 8), or PQ in combination with MB (n = 8) twice a week for 4 weeks and were sacrificed the day following the last injection. Significant loss of nigral DA neurons was observed in both treatment groups, but a significant decrease in striatal DA fibers was not found. Microglial activation was seen in the nigra of rats subjected to PQ with or without MB. Behavioral analyses demonstrated a mixed pattern of motor impairments, which may have been related to early effects of nigral DA neuronal loss or systemic effects associated with MB exposure in addition to PQ. These results indicate that exposure to PQ with or without MB induces neurodegeneration which might occur via an early inflammatory response in young adult animals. SN - 0969-9961 UR - https://www.unboundmedicine.com/medline/citation/16242641/Systemic_exposure_to_paraquat_and_maneb_models_early_Parkinson's_disease_in_young_adult_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(05)00094-X DB - PRIME DP - Unbound Medicine ER -