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snRNAs as the catalysts of pre-mRNA splicing.
Curr Opin Chem Biol. 2005 Dec; 9(6):603-8.CO

Abstract

The spliceosome, the gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules. The central role played by the spliceosomal RNAs in splicing has led to the hypothesis that, like the ribosome, the spliceosome is an RNA-centric enzyme and a relic from the RNA world. Recent structural studies have provided the first glimpses of the structural features of spliceosomal RNAs, and mutational analyses in vivo and in vitro have uncovered new functional roles for a catalytically essential domain. An emerging model for the active site of group II introns, a closely related class of natural ribozymes, is likely to provide a wealth of insights on structure and function of the active site of the spliceosome.

Authors+Show Affiliations

Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. saba.valadkhan@case.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16242989

Citation

Valadkhan, Saba. "SnRNAs as the Catalysts of pre-mRNA Splicing." Current Opinion in Chemical Biology, vol. 9, no. 6, 2005, pp. 603-8.
Valadkhan S. SnRNAs as the catalysts of pre-mRNA splicing. Curr Opin Chem Biol. 2005;9(6):603-8.
Valadkhan, S. (2005). SnRNAs as the catalysts of pre-mRNA splicing. Current Opinion in Chemical Biology, 9(6), 603-8.
Valadkhan S. SnRNAs as the Catalysts of pre-mRNA Splicing. Curr Opin Chem Biol. 2005;9(6):603-8. PubMed PMID: 16242989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - snRNAs as the catalysts of pre-mRNA splicing. A1 - Valadkhan,Saba, Y1 - 2005/10/20/ PY - 2005/07/21/received PY - 2005/10/07/accepted PY - 2005/10/26/pubmed PY - 2006/2/14/medline PY - 2005/10/26/entrez SP - 603 EP - 8 JF - Current opinion in chemical biology JO - Curr Opin Chem Biol VL - 9 IS - 6 N2 - The spliceosome, the gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules. The central role played by the spliceosomal RNAs in splicing has led to the hypothesis that, like the ribosome, the spliceosome is an RNA-centric enzyme and a relic from the RNA world. Recent structural studies have provided the first glimpses of the structural features of spliceosomal RNAs, and mutational analyses in vivo and in vitro have uncovered new functional roles for a catalytically essential domain. An emerging model for the active site of group II introns, a closely related class of natural ribozymes, is likely to provide a wealth of insights on structure and function of the active site of the spliceosome. SN - 1367-5931 UR - https://www.unboundmedicine.com/medline/citation/16242989/snRNAs_as_the_catalysts_of_pre_mRNA_splicing_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1367-5931(05)00141-9 DB - PRIME DP - Unbound Medicine ER -