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Testicular feminization syndrome in a mare.
J Am Vet Med Assoc. 1992 Jun 01; 200(11):1689-91.JA

Abstract

Testicular feminization syndrome was diagnosed in a mare with aggressive, stallion like behavior and a history of infertility. She was found to have a high baseline testosterone concentration suggesting that testicular tissue was present, and ovarian-like structures examined by use of transrectal ultrasonography had the appearance typical of testicular tissue. Although her external female genitalia appeared normal, her vagina ended in a blind sac, and no cervix or uterus were identified. Surgery was performed, and structures removed from the abdominal cavity were determined to be hypoplastic testicles. Removal of the testicular tissue resulted in complete resolution of her aggressive behavior. Chromosomal evaluation revealed that the mare had 64X,Y (normal male) karyotype. Testicular feminization syndrome is a condition characterized by insensitivity of reproductive tissues to androgens during development because of an abnormality in androgen receptors. This androgen insensitivity results in development of normal external female genitalia, with high testosterone concentrations being released from developing testicles. Testicular feminization syndrome has not been commonly diagnosed in horses, but should be considered as a differential diagnosis for overly aggressive mares with a history of infertility.

Authors+Show Affiliations

Department of Veterinary Clinical Medicine and Surgery, College of Veterinary Medicine, Washington State University, Pullman 99164-6610.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

1624347

Citation

Crabbe, B G., et al. "Testicular Feminization Syndrome in a Mare." Journal of the American Veterinary Medical Association, vol. 200, no. 11, 1992, pp. 1689-91.
Crabbe BG, Freeman DA, Grant BD, et al. Testicular feminization syndrome in a mare. J Am Vet Med Assoc. 1992;200(11):1689-91.
Crabbe, B. G., Freeman, D. A., Grant, B. D., Kennedy, P., Whitlatch, L., & MacRae, K. (1992). Testicular feminization syndrome in a mare. Journal of the American Veterinary Medical Association, 200(11), 1689-91.
Crabbe BG, et al. Testicular Feminization Syndrome in a Mare. J Am Vet Med Assoc. 1992 Jun 1;200(11):1689-91. PubMed PMID: 1624347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Testicular feminization syndrome in a mare. AU - Crabbe,B G, AU - Freeman,D A, AU - Grant,B D, AU - Kennedy,P, AU - Whitlatch,L, AU - MacRae,K, PY - 1992/6/1/pubmed PY - 1992/6/1/medline PY - 1992/6/1/entrez SP - 1689 EP - 91 JF - Journal of the American Veterinary Medical Association JO - J. Am. Vet. Med. Assoc. VL - 200 IS - 11 N2 - Testicular feminization syndrome was diagnosed in a mare with aggressive, stallion like behavior and a history of infertility. She was found to have a high baseline testosterone concentration suggesting that testicular tissue was present, and ovarian-like structures examined by use of transrectal ultrasonography had the appearance typical of testicular tissue. Although her external female genitalia appeared normal, her vagina ended in a blind sac, and no cervix or uterus were identified. Surgery was performed, and structures removed from the abdominal cavity were determined to be hypoplastic testicles. Removal of the testicular tissue resulted in complete resolution of her aggressive behavior. Chromosomal evaluation revealed that the mare had 64X,Y (normal male) karyotype. Testicular feminization syndrome is a condition characterized by insensitivity of reproductive tissues to androgens during development because of an abnormality in androgen receptors. This androgen insensitivity results in development of normal external female genitalia, with high testosterone concentrations being released from developing testicles. Testicular feminization syndrome has not been commonly diagnosed in horses, but should be considered as a differential diagnosis for overly aggressive mares with a history of infertility. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/1624347/Testicular_feminization_syndrome_in_a_mare_ L2 - https://medlineplus.gov/infertility.html DB - PRIME DP - Unbound Medicine ER -