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Association of estrogen receptor alpha gene polymorphisms with bone mineral density in postmenopausal Indian women.
Mol Genet Metab. 2006 Jan; 87(1):80-7.MG

Abstract

Bone mineral density (BMD) is the major determinant of osteoporotic fracture risk with a particular genetic background. However, consensus on the association of BMD with specific gene locus has not been reached. In the present study, we investigated the potential association of estrogen receptor alpha (ER alpha) gene intron I polymorphisms with BMD in 246 postmenopausal Indian women (average age 54.2+/-3.4 years). All the subjects were genotyped for XbaI and PvuII polymorphisms and underwent BMD measurements at spine and hip by dual energy X-ray absorptiometery. The average BMD of subjects with the genotypes XX and PP (absence of restriction sites for XbaI and PvuII, respectively) was 12.7 and 5.4% higher at the spine and 13.1 and 4.6% higher at the hip, respectively, than those with genotypes xx and pp. In age vs. BMD scatterplot, the intercept and slope of regression lines for genotypes xx and pp at spine and hip demonstrated comparatively rapid decrease in BMD across the age. The genotype XX was significantly prevalent (p<0.001) in women with normal bone mass (32%) and genotype xx in women with osteoporotic bone mass (35.3%), within the group. A significantly higher relative risk was associated with xx genotype. The study concludes that genetic variations at ER alpha gene locus, perhaps, are associated with BMD in Indian women and may influence some determinant of bone metabolism resulting in accelerated bone loss with age.

Authors+Show Affiliations

Molecular Immunodiagnostic Division, National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai 400012, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16243557

Citation

Mitra, Sumegha, et al. "Association of Estrogen Receptor Alpha Gene Polymorphisms With Bone Mineral Density in Postmenopausal Indian Women." Molecular Genetics and Metabolism, vol. 87, no. 1, 2006, pp. 80-7.
Mitra S, Desai M, Khatkhatay MI. Association of estrogen receptor alpha gene polymorphisms with bone mineral density in postmenopausal Indian women. Mol Genet Metab. 2006;87(1):80-7.
Mitra, S., Desai, M., & Khatkhatay, M. I. (2006). Association of estrogen receptor alpha gene polymorphisms with bone mineral density in postmenopausal Indian women. Molecular Genetics and Metabolism, 87(1), 80-7.
Mitra S, Desai M, Khatkhatay MI. Association of Estrogen Receptor Alpha Gene Polymorphisms With Bone Mineral Density in Postmenopausal Indian Women. Mol Genet Metab. 2006;87(1):80-7. PubMed PMID: 16243557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of estrogen receptor alpha gene polymorphisms with bone mineral density in postmenopausal Indian women. AU - Mitra,Sumegha, AU - Desai,Meena, AU - Khatkhatay,M Ikram, Y1 - 2005/10/21/ PY - 2005/06/02/received PY - 2005/06/03/accepted PY - 2005/10/26/pubmed PY - 2006/3/3/medline PY - 2005/10/26/entrez SP - 80 EP - 7 JF - Molecular genetics and metabolism JO - Mol Genet Metab VL - 87 IS - 1 N2 - Bone mineral density (BMD) is the major determinant of osteoporotic fracture risk with a particular genetic background. However, consensus on the association of BMD with specific gene locus has not been reached. In the present study, we investigated the potential association of estrogen receptor alpha (ER alpha) gene intron I polymorphisms with BMD in 246 postmenopausal Indian women (average age 54.2+/-3.4 years). All the subjects were genotyped for XbaI and PvuII polymorphisms and underwent BMD measurements at spine and hip by dual energy X-ray absorptiometery. The average BMD of subjects with the genotypes XX and PP (absence of restriction sites for XbaI and PvuII, respectively) was 12.7 and 5.4% higher at the spine and 13.1 and 4.6% higher at the hip, respectively, than those with genotypes xx and pp. In age vs. BMD scatterplot, the intercept and slope of regression lines for genotypes xx and pp at spine and hip demonstrated comparatively rapid decrease in BMD across the age. The genotype XX was significantly prevalent (p<0.001) in women with normal bone mass (32%) and genotype xx in women with osteoporotic bone mass (35.3%), within the group. A significantly higher relative risk was associated with xx genotype. The study concludes that genetic variations at ER alpha gene locus, perhaps, are associated with BMD in Indian women and may influence some determinant of bone metabolism resulting in accelerated bone loss with age. SN - 1096-7192 UR - https://www.unboundmedicine.com/medline/citation/16243557/Association_of_estrogen_receptor_alpha_gene_polymorphisms_with_bone_mineral_density_in_postmenopausal_Indian_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-7192(05)00181-2 DB - PRIME DP - Unbound Medicine ER -