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Ondansetron, orally disintegrating tablets versus intravenous injection for prevention of intrathecal morphine-induced nausea, vomiting, and pruritus in young males.
Anesth Analg. 2005 Nov; 101(5):1330-6.A&A

Abstract

In this study we compared the efficacy of orally disintegrating tablets (ODT) and IV ondansetron for preventing spinal morphine-induced pruritus and postoperative nausea and vomiting (PONV) in healthy young male patients. Patients who received bupivacaine with 0.20 mg morphine for spinal anesthesia were randomly assigned to the ODT group (ODT ondansetron 8 mg, n = 50), the IV group (4 mg ondansetron IV, n = 50), or the placebo group (n = 50). Each individual was assessed for pruritus, postoperative nausea and vomiting, and pain at 0, 2, 6, 12, 18, and 24 h after surgery using three distinct visual analog scales. The frequencies of postoperative nausea and vomiting and frequencies of requirement for rescue antiemetic and antipruritic were recorded. There were no significant differences among the three groups with respect to incidence or severity of PONV or postoperative pain visual analog scale scores. The incidences of pruritus in the ODT (56%) and IV (66%) groups were significantly different from that in the placebo group (86%) (P < 0.02 for both). Only the ODT group had significantly lower mean pruritus visual analog scale scores at 0, 2, 6, and 12 h postsurgery than the placebo group (P < 0.023 for all). The frequency of requirement for rescue antipruritic was significantly less in the ODT group than the placebo group (P = 0.013). Both ODT ondansetron 8 mg and IV ondansetron 4 mg are more effective than placebo for preventing spinal morphine-induced pruritus, but neither form of this agent reduces spinal morphine-induced postoperative nausea and vomiting in this patient group.

Authors+Show Affiliations

Başkent Universitesi Hastanesi Anesteziyoloji Anabilim Dalí 10. Sok. No: 45 Bahçelievler 06490, Ankara, Turkey. arashp@baskent-ank.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16243989

Citation

Pirat, Arash, et al. "Ondansetron, Orally Disintegrating Tablets Versus Intravenous Injection for Prevention of Intrathecal Morphine-induced Nausea, Vomiting, and Pruritus in Young Males." Anesthesia and Analgesia, vol. 101, no. 5, 2005, pp. 1330-6.
Pirat A, Tuncay SF, Torgay A, et al. Ondansetron, orally disintegrating tablets versus intravenous injection for prevention of intrathecal morphine-induced nausea, vomiting, and pruritus in young males. Anesth Analg. 2005;101(5):1330-6.
Pirat, A., Tuncay, S. F., Torgay, A., Candan, S., & Arslan, G. (2005). Ondansetron, orally disintegrating tablets versus intravenous injection for prevention of intrathecal morphine-induced nausea, vomiting, and pruritus in young males. Anesthesia and Analgesia, 101(5), 1330-6.
Pirat A, et al. Ondansetron, Orally Disintegrating Tablets Versus Intravenous Injection for Prevention of Intrathecal Morphine-induced Nausea, Vomiting, and Pruritus in Young Males. Anesth Analg. 2005;101(5):1330-6. PubMed PMID: 16243989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ondansetron, orally disintegrating tablets versus intravenous injection for prevention of intrathecal morphine-induced nausea, vomiting, and pruritus in young males. AU - Pirat,Arash, AU - Tuncay,Senay F, AU - Torgay,Adnan, AU - Candan,Selim, AU - Arslan,Gulnaz, PY - 2005/10/26/pubmed PY - 2005/12/13/medline PY - 2005/10/26/entrez SP - 1330 EP - 6 JF - Anesthesia and analgesia JO - Anesth Analg VL - 101 IS - 5 N2 - In this study we compared the efficacy of orally disintegrating tablets (ODT) and IV ondansetron for preventing spinal morphine-induced pruritus and postoperative nausea and vomiting (PONV) in healthy young male patients. Patients who received bupivacaine with 0.20 mg morphine for spinal anesthesia were randomly assigned to the ODT group (ODT ondansetron 8 mg, n = 50), the IV group (4 mg ondansetron IV, n = 50), or the placebo group (n = 50). Each individual was assessed for pruritus, postoperative nausea and vomiting, and pain at 0, 2, 6, 12, 18, and 24 h after surgery using three distinct visual analog scales. The frequencies of postoperative nausea and vomiting and frequencies of requirement for rescue antiemetic and antipruritic were recorded. There were no significant differences among the three groups with respect to incidence or severity of PONV or postoperative pain visual analog scale scores. The incidences of pruritus in the ODT (56%) and IV (66%) groups were significantly different from that in the placebo group (86%) (P < 0.02 for both). Only the ODT group had significantly lower mean pruritus visual analog scale scores at 0, 2, 6, and 12 h postsurgery than the placebo group (P < 0.023 for all). The frequency of requirement for rescue antipruritic was significantly less in the ODT group than the placebo group (P = 0.013). Both ODT ondansetron 8 mg and IV ondansetron 4 mg are more effective than placebo for preventing spinal morphine-induced pruritus, but neither form of this agent reduces spinal morphine-induced postoperative nausea and vomiting in this patient group. SN - 0003-2999 UR - https://www.unboundmedicine.com/medline/citation/16243989/Ondansetron_orally_disintegrating_tablets_versus_intravenous_injection_for_prevention_of_intrathecal_morphine_induced_nausea_vomiting_and_pruritus_in_young_males_ L2 - https://doi.org/10.1213/01.ANE.0000180830.12355.D9 DB - PRIME DP - Unbound Medicine ER -