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Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner.
Anesth Analg. 2005 Nov; 101(5):1343-8.A&A

Abstract

We prospectively examined the incidence of postoperative nausea and vomiting (PONV) in a group of 193 elderly surgical inpatients receiving no postoperative antiemetic prophylaxis. Risk factors for PONV and detailed data on postoperative opioid use were recorded. The overall postoperative vomiting (POV) rate was 23.8%, whereas postoperative nausea (PON) was 51.3%. Opioid use (P = 0.025), and female gender (P = 0.038) were identified as significantly influencing POV in this relatively small population. There was a strong logarithmic dose-response relationship between postoperative opioid dose and POV (r2= 0.98, P < 0.01), as well as PON (r2= 0.98, P = 0.01). Use of patient-controlled analgesia or epidural analgesia was a marker for large-dose opioid use (P < 0.001) and was associated with POV in the 24-h postoperative period of 41% and 31% respectively, compared with 11% for other patients (P < 0.001). Future studies defining risk factors for POV should treat postoperative opioid use as a continuous variable, rather than treat it as a dichotomous variable.

Authors+Show Affiliations

Pharmacy Department, Repatriation General Hospital, Daws Rd., Daw Park SA 5041, Australia. greg.roberts@rgh.sa.gov.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16243992

Citation

Roberts, Gregory W., et al. "Postoperative Nausea and Vomiting Are Strongly Influenced By Postoperative Opioid Use in a Dose-related Manner." Anesthesia and Analgesia, vol. 101, no. 5, 2005, pp. 1343-8.
Roberts GW, Bekker TB, Carlsen HH, et al. Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner. Anesth Analg. 2005;101(5):1343-8.
Roberts, G. W., Bekker, T. B., Carlsen, H. H., Moffatt, C. H., Slattery, P. J., & McClure, A. F. (2005). Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner. Anesthesia and Analgesia, 101(5), 1343-8.
Roberts GW, et al. Postoperative Nausea and Vomiting Are Strongly Influenced By Postoperative Opioid Use in a Dose-related Manner. Anesth Analg. 2005;101(5):1343-8. PubMed PMID: 16243992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner. AU - Roberts,Gregory W, AU - Bekker,Tenna B, AU - Carlsen,Helle H, AU - Moffatt,Christine H, AU - Slattery,Peter J, AU - McClure,Anna F, PY - 2005/10/26/pubmed PY - 2005/12/13/medline PY - 2005/10/26/entrez SP - 1343 EP - 8 JF - Anesthesia and analgesia JO - Anesth. Analg. VL - 101 IS - 5 N2 - We prospectively examined the incidence of postoperative nausea and vomiting (PONV) in a group of 193 elderly surgical inpatients receiving no postoperative antiemetic prophylaxis. Risk factors for PONV and detailed data on postoperative opioid use were recorded. The overall postoperative vomiting (POV) rate was 23.8%, whereas postoperative nausea (PON) was 51.3%. Opioid use (P = 0.025), and female gender (P = 0.038) were identified as significantly influencing POV in this relatively small population. There was a strong logarithmic dose-response relationship between postoperative opioid dose and POV (r2= 0.98, P < 0.01), as well as PON (r2= 0.98, P = 0.01). Use of patient-controlled analgesia or epidural analgesia was a marker for large-dose opioid use (P < 0.001) and was associated with POV in the 24-h postoperative period of 41% and 31% respectively, compared with 11% for other patients (P < 0.001). Future studies defining risk factors for POV should treat postoperative opioid use as a continuous variable, rather than treat it as a dichotomous variable. SN - 0003-2999 UR - https://www.unboundmedicine.com/medline/citation/16243992/Postoperative_nausea_and_vomiting_are_strongly_influenced_by_postoperative_opioid_use_in_a_dose_related_manner_ L2 - http://dx.doi.org/10.1213/01.ANE.0000180204.64588.EC DB - PRIME DP - Unbound Medicine ER -