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[Gamete and embryo protection against oxidative stress during medically assisted reproduction].
Bull Acad Natl Med. 2005 Apr; 189(4):715-26; discussion 726-8.BA

Abstract

So-called oxidative stress is due to the generation of reactive oxygen species (ROS), the most important of which are the superoxide anion (O2-*), hydrogen peroxide, and the hydroxyl radical OH*. ROS can damage gametes and embryos, through DNA (and RNA) fragmentation and membrane lipid peroxidation, potentially resulting in miscarriage. ROS are produced both physiologically (by oxidative metabolism) and in response to environmental factors such as oxygen, light, and traces of divalent cations. The body possesses several defense mechanisms against ROS, including antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione peroxidase, and also small molecules like vitamins (A, C and E), glutathione and pyruvate. These different systems generally act in concert. Embryonic cells also possess DNA repair machinery. As oxidative stress is one of the main sources of embryo loss in vitro, it is important to protect both gametes and embryos against these insults during medically assisted reproduction.

Authors+Show Affiliations

Institut Rhône Alpin, Laboratoire Marcel Mérieux, 1 rue Laborde, 69500 Bron.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

16245687

Citation

Ménézo, Yves, and Pierre Guérin. "[Gamete and Embryo Protection Against Oxidative Stress During Medically Assisted Reproduction]." Bulletin De l'Academie Nationale De Medecine, vol. 189, no. 4, 2005, pp. 715-26; discussion 726-8.
Ménézo Y, Guérin P. [Gamete and embryo protection against oxidative stress during medically assisted reproduction]. Bull Acad Natl Med. 2005;189(4):715-26; discussion 726-8.
Ménézo, Y., & Guérin, P. (2005). [Gamete and embryo protection against oxidative stress during medically assisted reproduction]. Bulletin De l'Academie Nationale De Medecine, 189(4), 715-26; discussion 726-8.
Ménézo Y, Guérin P. [Gamete and Embryo Protection Against Oxidative Stress During Medically Assisted Reproduction]. Bull Acad Natl Med. 2005;189(4):715-26; discussion 726-8. PubMed PMID: 16245687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Gamete and embryo protection against oxidative stress during medically assisted reproduction]. AU - Ménézo,Yves, AU - Guérin,Pierre, PY - 2005/10/26/pubmed PY - 2005/12/15/medline PY - 2005/10/26/entrez SP - 715-26; discussion 726-8 JF - Bulletin de l'Academie nationale de medecine JO - Bull Acad Natl Med VL - 189 IS - 4 N2 - So-called oxidative stress is due to the generation of reactive oxygen species (ROS), the most important of which are the superoxide anion (O2-*), hydrogen peroxide, and the hydroxyl radical OH*. ROS can damage gametes and embryos, through DNA (and RNA) fragmentation and membrane lipid peroxidation, potentially resulting in miscarriage. ROS are produced both physiologically (by oxidative metabolism) and in response to environmental factors such as oxygen, light, and traces of divalent cations. The body possesses several defense mechanisms against ROS, including antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione peroxidase, and also small molecules like vitamins (A, C and E), glutathione and pyruvate. These different systems generally act in concert. Embryonic cells also possess DNA repair machinery. As oxidative stress is one of the main sources of embryo loss in vitro, it is important to protect both gametes and embryos against these insults during medically assisted reproduction. SN - 0001-4079 UR - https://www.unboundmedicine.com/medline/citation/16245687/[Gamete_and_embryo_protection_against_oxidative_stress_during_medically_assisted_reproduction]_ L2 - https://medlineplus.gov/assistedreproductivetechnology.html DB - PRIME DP - Unbound Medicine ER -