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Protein aggregation, metals and oxidative stress in neurodegenerative diseases.
Biochem Soc Trans. 2005 Nov; 33(Pt 5):1082-6.BS

Abstract

There is clear evidence implicating oxidative stress in the pathology of many different neurodegenerative diseases. ROS (reactive oxygen species) are the primary mediators of oxidative stress and many of the aggregating proteins and peptides associated with neurodegenerative disease can generate hydrogen peroxide, a key ROS, apparently through interactions with redox-active metal ions. Our recent results suggest that ROS are generated during the very early stages of protein aggregation, when protofibrils or soluble oligomers are present, but in the absence of mature amyloid fibrils. The generation of ROS during early-stage protein aggregation may be a common, fundamental molecular mechanism underlying the pathogenesis of oxidative damage, neurodegeneration and cell death in several different neurodegenerative diseases. Drugs that specifically target this process could be useful in the future therapy of these diseases.

Authors+Show Affiliations

Magnetic Resonance Laboratory, University of Lancaster, Lancaster LA1 4YQ, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16246050

Citation

Tabner, B J., et al. "Protein Aggregation, Metals and Oxidative Stress in Neurodegenerative Diseases." Biochemical Society Transactions, vol. 33, no. Pt 5, 2005, pp. 1082-6.
Tabner BJ, El-Agnaf OM, German MJ, et al. Protein aggregation, metals and oxidative stress in neurodegenerative diseases. Biochem Soc Trans. 2005;33(Pt 5):1082-6.
Tabner, B. J., El-Agnaf, O. M., German, M. J., Fullwood, N. J., & Allsop, D. (2005). Protein aggregation, metals and oxidative stress in neurodegenerative diseases. Biochemical Society Transactions, 33(Pt 5), 1082-6.
Tabner BJ, et al. Protein Aggregation, Metals and Oxidative Stress in Neurodegenerative Diseases. Biochem Soc Trans. 2005;33(Pt 5):1082-6. PubMed PMID: 16246050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protein aggregation, metals and oxidative stress in neurodegenerative diseases. AU - Tabner,B J, AU - El-Agnaf,O M A, AU - German,M J, AU - Fullwood,N J, AU - Allsop,D, PY - 2005/10/26/pubmed PY - 2006/5/4/medline PY - 2005/10/26/entrez SP - 1082 EP - 6 JF - Biochemical Society transactions JO - Biochem. Soc. Trans. VL - 33 IS - Pt 5 N2 - There is clear evidence implicating oxidative stress in the pathology of many different neurodegenerative diseases. ROS (reactive oxygen species) are the primary mediators of oxidative stress and many of the aggregating proteins and peptides associated with neurodegenerative disease can generate hydrogen peroxide, a key ROS, apparently through interactions with redox-active metal ions. Our recent results suggest that ROS are generated during the very early stages of protein aggregation, when protofibrils or soluble oligomers are present, but in the absence of mature amyloid fibrils. The generation of ROS during early-stage protein aggregation may be a common, fundamental molecular mechanism underlying the pathogenesis of oxidative damage, neurodegeneration and cell death in several different neurodegenerative diseases. Drugs that specifically target this process could be useful in the future therapy of these diseases. SN - 0300-5127 UR - https://www.unboundmedicine.com/medline/citation/16246050/Protein_aggregation_metals_and_oxidative_stress_in_neurodegenerative_diseases_ L2 - https://portlandpress.com/biochemsoctrans/article-lookup/doi/10.1042/BST20051082 DB - PRIME DP - Unbound Medicine ER -