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Is there an association between ocular adnexal lymphoma and infection with Chlamydia psittaci? The University of Rochester experience.
Leuk Res. 2006 May; 30(5):547-51.LR

Abstract

Various subsets of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissues (MALT lymphomas) have been associated with infectious organisms. Most notable of these is the association of gastric MALT lymphomas with Helicobacter pylori infection. In a recent publication Ferreri et al. [Ferreri AJ, Guidoboni M, Ponzoni M, De Conciliis C, Dell'Oro S, Fleischhauer K, et al. Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas. J Natl Cancer Inst 2004;96:586-94] reported the presence of C. psittaci DNA in 80% of 40 ocular adnexal lymphomas. Similar to the gastric MALT lymphoma data, a subset of these patients responded well to antibiotic treatment. We analyzed a set of ocular adnexal lymphomas and benign (non-neoplastic) lesions for evidence of C. psittaci DNA in patients from New York State. No evidence of C. psittaci DNA was seen in seven MALT-type ocular adnexal lymphomas, four non-MALT ocular lymphomas, one Langerhans histiocytosis, and five reactive lymphoproliferations. We eliminated several possible reasons that would cause our study to fail to find C. psittaci DNA, including the presence of PCR inhibitors, inadequate template DNA, and sequence diversity in the target region in C. psittaci. The positive data were based primarily on patients from Italy, while our study involved only patients living in the Northeastern United States. This would suggest possible geographic differences in the etiology of ocular adnexal lymphomas.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, NY 14642, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16246419

Citation

Vargas, Roberto L., et al. "Is There an Association Between Ocular Adnexal Lymphoma and Infection With Chlamydia Psittaci? the University of Rochester Experience." Leukemia Research, vol. 30, no. 5, 2006, pp. 547-51.
Vargas RL, Fallone E, Felgar RE, et al. Is there an association between ocular adnexal lymphoma and infection with Chlamydia psittaci? The University of Rochester experience. Leuk Res. 2006;30(5):547-51.
Vargas, R. L., Fallone, E., Felgar, R. E., Friedberg, J. W., Arbini, A. A., Andersen, A. A., & Rothberg, P. G. (2006). Is there an association between ocular adnexal lymphoma and infection with Chlamydia psittaci? The University of Rochester experience. Leukemia Research, 30(5), 547-51.
Vargas RL, et al. Is There an Association Between Ocular Adnexal Lymphoma and Infection With Chlamydia Psittaci? the University of Rochester Experience. Leuk Res. 2006;30(5):547-51. PubMed PMID: 16246419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there an association between ocular adnexal lymphoma and infection with Chlamydia psittaci? The University of Rochester experience. AU - Vargas,Roberto L, AU - Fallone,Enzo, AU - Felgar,Raymond E, AU - Friedberg,Jonathan W, AU - Arbini,Arnaldo A, AU - Andersen,Arthur A, AU - Rothberg,Paul G, Y1 - 2005/10/24/ PY - 2005/08/03/received PY - 2005/09/21/revised PY - 2005/09/22/accepted PY - 2005/10/26/pubmed PY - 2006/9/1/medline PY - 2005/10/26/entrez SP - 547 EP - 51 JF - Leukemia research JO - Leuk. Res. VL - 30 IS - 5 N2 - Various subsets of extranodal marginal zone lymphomas of mucosa-associated lymphoid tissues (MALT lymphomas) have been associated with infectious organisms. Most notable of these is the association of gastric MALT lymphomas with Helicobacter pylori infection. In a recent publication Ferreri et al. [Ferreri AJ, Guidoboni M, Ponzoni M, De Conciliis C, Dell'Oro S, Fleischhauer K, et al. Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas. J Natl Cancer Inst 2004;96:586-94] reported the presence of C. psittaci DNA in 80% of 40 ocular adnexal lymphomas. Similar to the gastric MALT lymphoma data, a subset of these patients responded well to antibiotic treatment. We analyzed a set of ocular adnexal lymphomas and benign (non-neoplastic) lesions for evidence of C. psittaci DNA in patients from New York State. No evidence of C. psittaci DNA was seen in seven MALT-type ocular adnexal lymphomas, four non-MALT ocular lymphomas, one Langerhans histiocytosis, and five reactive lymphoproliferations. We eliminated several possible reasons that would cause our study to fail to find C. psittaci DNA, including the presence of PCR inhibitors, inadequate template DNA, and sequence diversity in the target region in C. psittaci. The positive data were based primarily on patients from Italy, while our study involved only patients living in the Northeastern United States. This would suggest possible geographic differences in the etiology of ocular adnexal lymphomas. SN - 0145-2126 UR - https://www.unboundmedicine.com/medline/citation/16246419/Is_there_an_association_between_ocular_adnexal_lymphoma_and_infection_with_Chlamydia_psittaci_The_University_of_Rochester_experience_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0145-2126(05)00367-X DB - PRIME DP - Unbound Medicine ER -