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Alcohol consumption and cognitive function in late life: a longitudinal community study.

Abstract

OBJECTIVE

To examine the association between alcohol use and cognitive decline in a longitudinal study of a representative elderly community sample free of dementia at baseline.

METHODS

Cognitive functions and self-reported drinking habits were assessed at 2-year intervals over an average of 7 years of follow-up. Cognitive measures, grouped into composites, were examined in association with alcohol consumption. Trajectory analyses identified latent homogeneous groups with respect to alcohol use frequency over time, and their association with average decline over the same period in each cognitive domain. Models controlled for age, sex, education, depression, smoking, general mental status (Mini-Mental State Examination [MMSE]), performance on the given test at baseline, and subsequent new-onset dementia during follow-up.

RESULTS

The authors found three homogeneous trajectories that they characterized as no drinking, minimal drinking, and moderate drinking. Few heavy drinkers were identified in this elderly cohort. Compared to no drinking, both minimal and moderate drinking were associated with lesser decline on the MMSE and Trailmaking tests. Minimal drinking was also associated with lesser decline on tests of learning and naming. These associations were more pronounced when comparing current drinkers to former drinkers (quitters) than to lifelong abstainers.

CONCLUSION

In a representative elderly cohort over an average of 7 years, a pattern of mild-to-moderate drinking, compared to not drinking, was associated with lesser average decline in cognitive domains over the same period.

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  • Authors+Show Affiliations

    ,

    Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. gangulim@upmc.edu

    , , ,

    Source

    Neurology 65:8 2005 Oct 25 pg 1210-7

    MeSH

    Age Factors
    Aged
    Aged, 80 and over
    Aging
    Alcohol Amnestic Disorder
    Alcohol Drinking
    Alcohol-Induced Disorders, Nervous System
    Causality
    Cognition Disorders
    Cohort Studies
    Disease Progression
    Dose-Response Relationship, Drug
    Female
    Follow-Up Studies
    Humans
    Longitudinal Studies
    Male
    Memory Disorders
    Neuropsychological Tests
    Pennsylvania

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    16247047

    Citation

    Ganguli, M, et al. "Alcohol Consumption and Cognitive Function in Late Life: a Longitudinal Community Study." Neurology, vol. 65, no. 8, 2005, pp. 1210-7.
    Ganguli M, Vander Bilt J, Saxton JA, et al. Alcohol consumption and cognitive function in late life: a longitudinal community study. Neurology. 2005;65(8):1210-7.
    Ganguli, M., Vander Bilt, J., Saxton, J. A., Shen, C., & Dodge, H. H. (2005). Alcohol consumption and cognitive function in late life: a longitudinal community study. Neurology, 65(8), pp. 1210-7.
    Ganguli M, et al. Alcohol Consumption and Cognitive Function in Late Life: a Longitudinal Community Study. Neurology. 2005 Oct 25;65(8):1210-7. PubMed PMID: 16247047.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and cognitive function in late life: a longitudinal community study. AU - Ganguli,M, AU - Vander Bilt,J, AU - Saxton,J A, AU - Shen,C, AU - Dodge,H H, PY - 2005/10/26/pubmed PY - 2006/4/15/medline PY - 2005/10/26/entrez SP - 1210 EP - 7 JF - Neurology JO - Neurology VL - 65 IS - 8 N2 - OBJECTIVE: To examine the association between alcohol use and cognitive decline in a longitudinal study of a representative elderly community sample free of dementia at baseline. METHODS: Cognitive functions and self-reported drinking habits were assessed at 2-year intervals over an average of 7 years of follow-up. Cognitive measures, grouped into composites, were examined in association with alcohol consumption. Trajectory analyses identified latent homogeneous groups with respect to alcohol use frequency over time, and their association with average decline over the same period in each cognitive domain. Models controlled for age, sex, education, depression, smoking, general mental status (Mini-Mental State Examination [MMSE]), performance on the given test at baseline, and subsequent new-onset dementia during follow-up. RESULTS: The authors found three homogeneous trajectories that they characterized as no drinking, minimal drinking, and moderate drinking. Few heavy drinkers were identified in this elderly cohort. Compared to no drinking, both minimal and moderate drinking were associated with lesser decline on the MMSE and Trailmaking tests. Minimal drinking was also associated with lesser decline on tests of learning and naming. These associations were more pronounced when comparing current drinkers to former drinkers (quitters) than to lifelong abstainers. CONCLUSION: In a representative elderly cohort over an average of 7 years, a pattern of mild-to-moderate drinking, compared to not drinking, was associated with lesser average decline in cognitive domains over the same period. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16247047/Alcohol_consumption_and_cognitive_function_in_late_life:_a_longitudinal_community_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16247047 DB - PRIME DP - Unbound Medicine ER -