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Decline in cognitive and functional skills increases mortality risk in nondemented elderly.
Neurology. 2005 Oct 25; 65(8):1218-26.Neur

Abstract

OBJECTIVE

To investigate the relation between rate of decline in cognitive and functional/physical abilities and risk of death in nondemented elderly.

METHODS

Data were included from individuals participating in a prospective study of aging and dementia in Medicare recipients, 65 years and older, residing in northern Manhattan. The authors included 878 members of the cohort who had measures of memory, cognitive, language, or functional scores over three study intervals, excluding all participants who were demented or had more than one problem in activity of daily living (ADL) skills at baseline. Participants were classified as showing no decline, slow, medium, or rapid rate of decline, based on the slope of change in cognitive and functional/physical factors. The authors used survival methods to examine the relation of rate of decline in cognitive and functional performance to subsequent mortality in younger and older nondemented elderly and across three ethnic groups, adjusting for potential confounders.

RESULTS

Nondemented elderly with preserved ADL skills who showed rapid rates of decline on measures of visuospatial reasoning/cognitive, language, ADL, and instrumental ADL functions were approximately twice as likely to die as nondemented elderly who showed no decline or slower rates of decline, while rate of decline in memory or in measures of extremity mobility was not related to risk of death. The association of the rate of decline to risk of death was stronger in relatively young (< or =75 years) than in older participants.

CONCLUSIONS

Rate of decline in cognitive and functional skills predicts mortality in nondemented elderly.

Authors+Show Affiliations

G.H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16247048

Citation

Schupf, N, et al. "Decline in Cognitive and Functional Skills Increases Mortality Risk in Nondemented Elderly." Neurology, vol. 65, no. 8, 2005, pp. 1218-26.
Schupf N, Tang MX, Albert SM, et al. Decline in cognitive and functional skills increases mortality risk in nondemented elderly. Neurology. 2005;65(8):1218-26.
Schupf, N., Tang, M. X., Albert, S. M., Costa, R., Andrews, H., Lee, J. H., & Mayeux, R. (2005). Decline in cognitive and functional skills increases mortality risk in nondemented elderly. Neurology, 65(8), 1218-26.
Schupf N, et al. Decline in Cognitive and Functional Skills Increases Mortality Risk in Nondemented Elderly. Neurology. 2005 Oct 25;65(8):1218-26. PubMed PMID: 16247048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decline in cognitive and functional skills increases mortality risk in nondemented elderly. AU - Schupf,N, AU - Tang,M-X, AU - Albert,S M, AU - Costa,R, AU - Andrews,H, AU - Lee,J H, AU - Mayeux,R, PY - 2005/10/26/pubmed PY - 2006/4/15/medline PY - 2005/10/26/entrez SP - 1218 EP - 26 JF - Neurology JO - Neurology VL - 65 IS - 8 N2 - OBJECTIVE: To investigate the relation between rate of decline in cognitive and functional/physical abilities and risk of death in nondemented elderly. METHODS: Data were included from individuals participating in a prospective study of aging and dementia in Medicare recipients, 65 years and older, residing in northern Manhattan. The authors included 878 members of the cohort who had measures of memory, cognitive, language, or functional scores over three study intervals, excluding all participants who were demented or had more than one problem in activity of daily living (ADL) skills at baseline. Participants were classified as showing no decline, slow, medium, or rapid rate of decline, based on the slope of change in cognitive and functional/physical factors. The authors used survival methods to examine the relation of rate of decline in cognitive and functional performance to subsequent mortality in younger and older nondemented elderly and across three ethnic groups, adjusting for potential confounders. RESULTS: Nondemented elderly with preserved ADL skills who showed rapid rates of decline on measures of visuospatial reasoning/cognitive, language, ADL, and instrumental ADL functions were approximately twice as likely to die as nondemented elderly who showed no decline or slower rates of decline, while rate of decline in memory or in measures of extremity mobility was not related to risk of death. The association of the rate of decline to risk of death was stronger in relatively young (< or =75 years) than in older participants. CONCLUSIONS: Rate of decline in cognitive and functional skills predicts mortality in nondemented elderly. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16247048/Decline_in_cognitive_and_functional_skills_increases_mortality_risk_in_nondemented_elderly_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=16247048 DB - PRIME DP - Unbound Medicine ER -