Tags

Type your tag names separated by a space and hit enter

Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study.
Int J Obes (Lond). 2006 Feb; 30(2):251-60.IJ

Abstract

INTRODUCTION

Although lipid profiles tend to worsen with age, it is not fully known if such age-related changes are influenced primarily by body composition and lifestyle or by other aspects of aging.

OBJECTIVE

We investigated the extent to which the fat and fat-free components of body mass index (BMI) and lifestyle factors influence patterns of change in lipids independent of age.

DESIGN

Serial data were analyzed using sex-specific longitudinal models. These models use serial data from individuals to assume a general pattern of change over time, while allowing baseline age and the rate of change to vary among individuals.

SUBJECTS

Serial data were obtained from 940 examinations of 269 healthy white participants (126 men, 143 women), aged 40-60 years, in the Fels Longitudinal Study.

MEASUREMENTS

Measurements included age, the fat (FMI) and fat-free mass (FFMI) components of BMI, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), triglycerides (TG), total cholesterol (TC), fasting glucose and insulin, physical activity, alcohol use and smoking, and women's menopausal status and estrogen use.

RESULTS

In both sexes, increased FMI was significantly associated with increased LDL-C, TG and TC, and decreased HDL-C. Increased FFMI was significantly related to decreased HDL-C and increased TG. Independent age effects remained significant only for LDL-C and TC in men and TC in women. Increased insulin was significantly related to increased TG in women. Moderate alcohol consumption was associated with higher HDL-C in men. Physical activity lowered male LDL-C and TC levels, and increased female HDL-C levels. Menopause was associated with increases in LDL-C. Premenopausal women not using estrogen had significantly lower HDL-C, TG, and TC than postmenopausal women taking estrogen.

CONCLUSIONS

(1) Age is an important independent predictor for LDL-C and TC in men, and TC in women, but it is not as influential as body composition and lifestyle on HDL-C and TG in men and women, and LDL-C in women. (2) Increasing FMI is the major contributor to elevated TC, LDL-C and TG levels, and decreased HDL-C levels in men and women. (3) FFMI significantly influences HDL and TG levels in both sexes. (4) Maintaining a lower BMI via a reduced fat component may be more beneficial in lowering CVD risks than other factors.

Authors+Show Affiliations

Lifespan Health Research Center, Department of Community Health, Wright State University School of Medicine, Dayton, OH 45420, USA. christine.schubert@wright.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16247511

Citation

Schubert, C M., et al. "Lipids, Lipoproteins, Lifestyle, Adiposity and Fat-free Mass During Middle Age: the Fels Longitudinal Study." International Journal of Obesity (2005), vol. 30, no. 2, 2006, pp. 251-60.
Schubert CM, Rogers NL, Remsberg KE, et al. Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study. Int J Obes (Lond). 2006;30(2):251-60.
Schubert, C. M., Rogers, N. L., Remsberg, K. E., Sun, S. S., Chumlea, W. C., Demerath, E. W., Czerwinski, S. A., Towne, B., & Siervogel, R. M. (2006). Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study. International Journal of Obesity (2005), 30(2), 251-60.
Schubert CM, et al. Lipids, Lipoproteins, Lifestyle, Adiposity and Fat-free Mass During Middle Age: the Fels Longitudinal Study. Int J Obes (Lond). 2006;30(2):251-60. PubMed PMID: 16247511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipids, lipoproteins, lifestyle, adiposity and fat-free mass during middle age: the Fels Longitudinal Study. AU - Schubert,C M, AU - Rogers,N L, AU - Remsberg,K E, AU - Sun,S S, AU - Chumlea,W C, AU - Demerath,E W, AU - Czerwinski,S A, AU - Towne,B, AU - Siervogel,R M, PY - 2005/10/26/pubmed PY - 2006/10/31/medline PY - 2005/10/26/entrez SP - 251 EP - 60 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 30 IS - 2 N2 - INTRODUCTION: Although lipid profiles tend to worsen with age, it is not fully known if such age-related changes are influenced primarily by body composition and lifestyle or by other aspects of aging. OBJECTIVE: We investigated the extent to which the fat and fat-free components of body mass index (BMI) and lifestyle factors influence patterns of change in lipids independent of age. DESIGN: Serial data were analyzed using sex-specific longitudinal models. These models use serial data from individuals to assume a general pattern of change over time, while allowing baseline age and the rate of change to vary among individuals. SUBJECTS: Serial data were obtained from 940 examinations of 269 healthy white participants (126 men, 143 women), aged 40-60 years, in the Fels Longitudinal Study. MEASUREMENTS: Measurements included age, the fat (FMI) and fat-free mass (FFMI) components of BMI, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), triglycerides (TG), total cholesterol (TC), fasting glucose and insulin, physical activity, alcohol use and smoking, and women's menopausal status and estrogen use. RESULTS: In both sexes, increased FMI was significantly associated with increased LDL-C, TG and TC, and decreased HDL-C. Increased FFMI was significantly related to decreased HDL-C and increased TG. Independent age effects remained significant only for LDL-C and TC in men and TC in women. Increased insulin was significantly related to increased TG in women. Moderate alcohol consumption was associated with higher HDL-C in men. Physical activity lowered male LDL-C and TC levels, and increased female HDL-C levels. Menopause was associated with increases in LDL-C. Premenopausal women not using estrogen had significantly lower HDL-C, TG, and TC than postmenopausal women taking estrogen. CONCLUSIONS: (1) Age is an important independent predictor for LDL-C and TC in men, and TC in women, but it is not as influential as body composition and lifestyle on HDL-C and TG in men and women, and LDL-C in women. (2) Increasing FMI is the major contributor to elevated TC, LDL-C and TG levels, and decreased HDL-C levels in men and women. (3) FFMI significantly influences HDL and TG levels in both sexes. (4) Maintaining a lower BMI via a reduced fat component may be more beneficial in lowering CVD risks than other factors. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16247511/Lipids_lipoproteins_lifestyle_adiposity_and_fat_free_mass_during_middle_age:_the_Fels_Longitudinal_Study_ L2 - http://dx.doi.org/10.1038/sj.ijo.0803129 DB - PRIME DP - Unbound Medicine ER -