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Prenatal detection of associated anomalies in fetuses diagnosed with cleft lip with or without cleft palate in utero.
Ultrasound Obstet Gynecol. 2006 Feb; 27(2):173-6.UO

Abstract

OBJECTIVE

The aim of this study was to determine the prenatal detection rate of associated anomalies in fetuses with a suspected cleft lip with or without cleft palate.

METHODS

Fetuses with a suspected cleft lip with or without cleft palate, determined by prenatal ultrasound, were prospectively enrolled. Additional anomalies suspected by ultrasound or genetic testing were recorded. Postnatal outcome was obtained.

RESULTS

Forty-five fetuses with a cleft lip with or without cleft palate, diagnosed prenatally with either two-dimensional and/or three-dimensional ultrasound, were studied. Postnatal follow-up revealed that 16 (35.6%) of these 45 fetuses had an additional structural or syndromic abnormality. Of the 37 fetuses with prenatally determined 'isolated' cleft lip with or without cleft palate, eight (21.6%) had an additional malformation identified after delivery.

CONCLUSION

In pregnancies complicated by a cleft lip with or without cleft palate, patients should be informed of the risks of associated anomalies, some of which may be undetected prenatally.

Authors+Show Affiliations

Florida Institute for Fetal Diagnosis and Therapy, Tampa, FL, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16247756

Citation

Chmait, R, et al. "Prenatal Detection of Associated Anomalies in Fetuses Diagnosed With Cleft Lip With or Without Cleft Palate in Utero." Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, vol. 27, no. 2, 2006, pp. 173-6.
Chmait R, Pretorius D, Moore T, et al. Prenatal detection of associated anomalies in fetuses diagnosed with cleft lip with or without cleft palate in utero. Ultrasound Obstet Gynecol. 2006;27(2):173-6.
Chmait, R., Pretorius, D., Moore, T., Hull, A., James, G., Nelson, T., & Jones, M. (2006). Prenatal detection of associated anomalies in fetuses diagnosed with cleft lip with or without cleft palate in utero. Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, 27(2), 173-6.
Chmait R, et al. Prenatal Detection of Associated Anomalies in Fetuses Diagnosed With Cleft Lip With or Without Cleft Palate in Utero. Ultrasound Obstet Gynecol. 2006;27(2):173-6. PubMed PMID: 16247756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal detection of associated anomalies in fetuses diagnosed with cleft lip with or without cleft palate in utero. AU - Chmait,R, AU - Pretorius,D, AU - Moore,T, AU - Hull,A, AU - James,G, AU - Nelson,T, AU - Jones,M, PY - 2005/10/26/pubmed PY - 2006/12/9/medline PY - 2005/10/26/entrez SP - 173 EP - 6 JF - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JO - Ultrasound Obstet Gynecol VL - 27 IS - 2 N2 - OBJECTIVE: The aim of this study was to determine the prenatal detection rate of associated anomalies in fetuses with a suspected cleft lip with or without cleft palate. METHODS: Fetuses with a suspected cleft lip with or without cleft palate, determined by prenatal ultrasound, were prospectively enrolled. Additional anomalies suspected by ultrasound or genetic testing were recorded. Postnatal outcome was obtained. RESULTS: Forty-five fetuses with a cleft lip with or without cleft palate, diagnosed prenatally with either two-dimensional and/or three-dimensional ultrasound, were studied. Postnatal follow-up revealed that 16 (35.6%) of these 45 fetuses had an additional structural or syndromic abnormality. Of the 37 fetuses with prenatally determined 'isolated' cleft lip with or without cleft palate, eight (21.6%) had an additional malformation identified after delivery. CONCLUSION: In pregnancies complicated by a cleft lip with or without cleft palate, patients should be informed of the risks of associated anomalies, some of which may be undetected prenatally. SN - 0960-7692 UR - https://www.unboundmedicine.com/medline/citation/16247756/Prenatal_detection_of_associated_anomalies_in_fetuses_diagnosed_with_cleft_lip_with_or_without_cleft_palate_in_utero_ L2 - https://doi.org/10.1002/uog.2593 DB - PRIME DP - Unbound Medicine ER -