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[Myosin light chains of skeletal and cardiac muscles of ground squirrel Citillus undulatus in different periods of hibernation].

Abstract

The isoform composition of myosin light chains and the extent of their phosphorylation in skeletal and cardiac muscles of ground squirrel Citellus undulatus in different periods of hibernation were studied. Regulatory myosin light chains of skeletal muscles of hibernating ground squirrels were completely dephosphorylated, while 25% of these light chains in active animals were phosphorylated. During hibernation, a shift of isoform composition of essential and regulatory skeletal muscle myosin light chains toward slower isoforms was observed, which is evidenced by the data obtained on m. psoas and on the totality of all skeletal muscles. In the atrial myocardium of hibernating ground squirrels, ventricular myosin light chains 1 (up to 60%) were registered. In contrast, during arousal of ground squirrels, in ventricular myocardium the appearance of atrial myosin light chains 1 (up to 30%) was revealed. A possible role of posttranslation changes in myosin light chains and their isoform shifts in the hibernation scenario is discussed.

Authors

, , , , ,

Source

Biofizika 50:5 pg 797-802

MeSH

Animals
Heart Atria
Hibernation
Muscle, Skeletal
Myocardium
Myosin Light Chains
Phosphorylation
Protein Isoforms
Protein Processing, Post-Translational
Sciuridae

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

16248153

Citation

Zuĭkova, O V., et al. "[Myosin Light Chains of Skeletal and Cardiac Muscles of Ground Squirrel Citillus Undulatus in Different Periods of Hibernation]." Biofizika, vol. 50, no. 5, 2005, pp. 797-802.
Zuĭkova OV, Osipova DA, Vikhliantsev IM, et al. [Myosin light chains of skeletal and cardiac muscles of ground squirrel Citillus undulatus in different periods of hibernation]. Biofizika. 2005;50(5):797-802.
Zuĭkova, O. V., Osipova, D. A., Vikhliantsev, I. M., Malyshev, S. L., Udal'tsov, S. N., & Podlubnaia, Z. A. (2005). [Myosin light chains of skeletal and cardiac muscles of ground squirrel Citillus undulatus in different periods of hibernation]. Biofizika, 50(5), pp. 797-802.
Zuĭkova OV, et al. [Myosin Light Chains of Skeletal and Cardiac Muscles of Ground Squirrel Citillus Undulatus in Different Periods of Hibernation]. Biofizika. 2005;50(5):797-802. PubMed PMID: 16248153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Myosin light chains of skeletal and cardiac muscles of ground squirrel Citillus undulatus in different periods of hibernation]. AU - Zuĭkova,O V, AU - Osipova,D A, AU - Vikhliantsev,I M, AU - Malyshev,S L, AU - Udal'tsov,S N, AU - Podlubnaia,Z A, PY - 2005/10/27/pubmed PY - 2005/12/22/medline PY - 2005/10/27/entrez SP - 797 EP - 802 JF - Biofizika JO - Biofizika VL - 50 IS - 5 N2 - The isoform composition of myosin light chains and the extent of their phosphorylation in skeletal and cardiac muscles of ground squirrel Citellus undulatus in different periods of hibernation were studied. Regulatory myosin light chains of skeletal muscles of hibernating ground squirrels were completely dephosphorylated, while 25% of these light chains in active animals were phosphorylated. During hibernation, a shift of isoform composition of essential and regulatory skeletal muscle myosin light chains toward slower isoforms was observed, which is evidenced by the data obtained on m. psoas and on the totality of all skeletal muscles. In the atrial myocardium of hibernating ground squirrels, ventricular myosin light chains 1 (up to 60%) were registered. In contrast, during arousal of ground squirrels, in ventricular myocardium the appearance of atrial myosin light chains 1 (up to 30%) was revealed. A possible role of posttranslation changes in myosin light chains and their isoform shifts in the hibernation scenario is discussed. SN - 0006-3029 UR - https://www.unboundmedicine.com/medline/citation/16248153/[Myosin_light_chains_of_skeletal_and_cardiac_muscles_of_ground_squirrel_Citillus_undulatus_in_different_periods_of_hibernation]_ DB - PRIME DP - Unbound Medicine ER -