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Spontaneous regression of hepatitis B virus-associated cirrhosis developed in childhood.
Dig Liver Dis. 2005 Dec; 37(12):964-7.DL

Abstract

We reported two cases of hepatitis B virus infection-related cirrhosis developed during childhood and followed up for more than 20 years. Both the subjects remained untreated, and ultimately regression of cirrhosis was documented by clinical (including ultrasound) and histological examination. Recent studies have already suggested that hepatitis B virus-related cirrhosis may regress after treatment, but this is the first demonstration that hepatitis B virus-associated cirrhosis developed in childhood may be a spontaneously reversible process. Subsidence of virus replication and of necro-inflammatory process and the efficiency of liver regeneration and repair might contribute to this favourable outcome.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, Clinica Medica 5, University of Padua, Policlinico, Via Giustiniani 2, Italy. flavia.bortolotti@unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16249128

Citation

Bortolotti, F, et al. "Spontaneous Regression of Hepatitis B Virus-associated Cirrhosis Developed in Childhood." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 37, no. 12, 2005, pp. 964-7.
Bortolotti F, Guido M, Cadrobbi P, et al. Spontaneous regression of hepatitis B virus-associated cirrhosis developed in childhood. Dig Liver Dis. 2005;37(12):964-7.
Bortolotti, F., Guido, M., Cadrobbi, P., Crivellaro, C., Bartolacci, S., Rugge, M., & Gatta, A. (2005). Spontaneous regression of hepatitis B virus-associated cirrhosis developed in childhood. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 37(12), 964-7.
Bortolotti F, et al. Spontaneous Regression of Hepatitis B Virus-associated Cirrhosis Developed in Childhood. Dig Liver Dis. 2005;37(12):964-7. PubMed PMID: 16249128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spontaneous regression of hepatitis B virus-associated cirrhosis developed in childhood. AU - Bortolotti,F, AU - Guido,M, AU - Cadrobbi,P, AU - Crivellaro,C, AU - Bartolacci,S, AU - Rugge,M, AU - Gatta,A, Y1 - 2005/10/24/ PY - 2004/12/14/received PY - 2005/04/29/accepted PY - 2005/10/27/pubmed PY - 2006/3/8/medline PY - 2005/10/27/entrez SP - 964 EP - 7 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 37 IS - 12 N2 - We reported two cases of hepatitis B virus infection-related cirrhosis developed during childhood and followed up for more than 20 years. Both the subjects remained untreated, and ultimately regression of cirrhosis was documented by clinical (including ultrasound) and histological examination. Recent studies have already suggested that hepatitis B virus-related cirrhosis may regress after treatment, but this is the first demonstration that hepatitis B virus-associated cirrhosis developed in childhood may be a spontaneously reversible process. Subsidence of virus replication and of necro-inflammatory process and the efficiency of liver regeneration and repair might contribute to this favourable outcome. SN - 1590-8658 UR - https://www.unboundmedicine.com/medline/citation/16249128/Spontaneous_regression_of_hepatitis_B_virus_associated_cirrhosis_developed_in_childhood_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(05)00381-6 DB - PRIME DP - Unbound Medicine ER -