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[Reproductive aspects of celiac disease].
Ann Ital Med Int 2005 Jul-Sep; 20(3):143-57AI

Abstract

In the past, celiac disease (CD), or intolerance to gluten, was considered a rare disease of infancy characterized by chronic diarrhea with malabsorption and delayed growth. Besides the overt enteropathy, there are other clinic and subclinical forms which appear later in life. Target organs are not limited to the gut, but include liver, thyroid, skin and female and male reproductive systems. CD interference on reproduction is related to the multifactorial nature of the disease, whose pathological manifestations can be modulated, besides gluten, by different concurrent genetic and environmental factors. CD induces malabsorption with consequent deficiencies of micronutrients such as iron, folic acid and vitamin K, which are essential for organogenesis, and fat-soluble vitamins important for spermatogenesis. Regarding endocrine disorders, the deficiencies of specific trace elements on ovarian function could explain its involvement in the increased risk of female osteoporosis in CD patients. Affected males show a picture of tissue resistance to androgens; the increases of follicle-stimulating hormone and prolactin, not associated with infertility, may indicate an imbalance at hypothalamus-pituitary level, with general effects on health. Since reproductive alterations are reversible, adoption of a gluten-free diet supported by early diagnosis is important. Therefore, the detection of early biomarkers, such as deficiencies of vitamins and/or iron and andrological or endocrinological dysfunctions, should trigger timely strategies for prevention and treatment.

Authors+Show Affiliations

Dipartimento Ambiente e connessa Prevenzione Primaria, Reparto di Tossicologia Genetica Istituto Superiore di Sanità, Università degli Studi La Sapienza, Roma. avelia@iss.itNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

ita

PubMed ID

16250182

Citation

Stazi, Anna Velia, and Biagino Trinti. "[Reproductive Aspects of Celiac Disease]." Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna, vol. 20, no. 3, 2005, pp. 143-57.
Stazi AV, Trinti B. [Reproductive aspects of celiac disease]. Ann Ital Med Int. 2005;20(3):143-57.
Stazi, A. V., & Trinti, B. (2005). [Reproductive aspects of celiac disease]. Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna, 20(3), pp. 143-57.
Stazi AV, Trinti B. [Reproductive Aspects of Celiac Disease]. Ann Ital Med Int. 2005;20(3):143-57. PubMed PMID: 16250182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Reproductive aspects of celiac disease]. AU - Stazi,Anna Velia, AU - Trinti,Biagino, PY - 2005/10/28/pubmed PY - 2005/12/15/medline PY - 2005/10/28/entrez SP - 143 EP - 57 JF - Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna JO - Ann. Ital. Med. Int. VL - 20 IS - 3 N2 - In the past, celiac disease (CD), or intolerance to gluten, was considered a rare disease of infancy characterized by chronic diarrhea with malabsorption and delayed growth. Besides the overt enteropathy, there are other clinic and subclinical forms which appear later in life. Target organs are not limited to the gut, but include liver, thyroid, skin and female and male reproductive systems. CD interference on reproduction is related to the multifactorial nature of the disease, whose pathological manifestations can be modulated, besides gluten, by different concurrent genetic and environmental factors. CD induces malabsorption with consequent deficiencies of micronutrients such as iron, folic acid and vitamin K, which are essential for organogenesis, and fat-soluble vitamins important for spermatogenesis. Regarding endocrine disorders, the deficiencies of specific trace elements on ovarian function could explain its involvement in the increased risk of female osteoporosis in CD patients. Affected males show a picture of tissue resistance to androgens; the increases of follicle-stimulating hormone and prolactin, not associated with infertility, may indicate an imbalance at hypothalamus-pituitary level, with general effects on health. Since reproductive alterations are reversible, adoption of a gluten-free diet supported by early diagnosis is important. Therefore, the detection of early biomarkers, such as deficiencies of vitamins and/or iron and andrological or endocrinological dysfunctions, should trigger timely strategies for prevention and treatment. SN - 0393-9340 UR - https://www.unboundmedicine.com/medline/citation/16250182/[Reproductive_aspects_of_celiac_disease]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -