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Neurological manifestations in severe acute respiratory syndrome.
Acta Neurol Taiwan. 2005 Sep; 14(3):113-9.AN

Abstract

During the worldwide outbreak of severe acute respiratory syndrome (SARS) in 2002-2003, there were 664 probable SARS patients reported in Taiwan. SARS patients usually present with symptoms related to the respiratory system while neurological manifestations have rarely been described. There were three patients who developed axonopathic polyneuropathy 3-4 weeks after onset of SARS; their clinical condition and electrophysiological studies revealed obvious improvement at follow-up. Two SARS patients have experienced myopathy and three other patients developed rhabdomyolysis. These neuromuscular disorders in SARS patients were considered as critical illness neuropathy and myopathy, but the possibility of direct attack by SARS coronavirus on the nerve and muscle could not be excluded. Large artery ischemic stroke were described in five SARS patients with poor prognosis. Multiple factors contributed to this vascular insult included hypercoagulabe status related to both SARS coronavirous and the usage of intravenous immunoglobulin, septic and cardiogenic shock, and possible vasculitis. The relationship between SARS and above neurological problems still needs further clarification. Pathological and microbiological studies are mandatory to delineate this issue.

Authors+Show Affiliations

Department of Neurology, National Taiwan University Hospital. No. 7, Chung-Shan South Road, Taipei, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16252612

Citation

Tsai, Li-Kai, et al. "Neurological Manifestations in Severe Acute Respiratory Syndrome." Acta Neurologica Taiwanica, vol. 14, no. 3, 2005, pp. 113-9.
Tsai LK, Hsieh ST, Chang YC. Neurological manifestations in severe acute respiratory syndrome. Acta Neurol Taiwan. 2005;14(3):113-9.
Tsai, L. K., Hsieh, S. T., & Chang, Y. C. (2005). Neurological manifestations in severe acute respiratory syndrome. Acta Neurologica Taiwanica, 14(3), 113-9.
Tsai LK, Hsieh ST, Chang YC. Neurological Manifestations in Severe Acute Respiratory Syndrome. Acta Neurol Taiwan. 2005;14(3):113-9. PubMed PMID: 16252612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological manifestations in severe acute respiratory syndrome. AU - Tsai,Li-Kai, AU - Hsieh,Sung-Tsang, AU - Chang,Yang-Chyuan, PY - 2005/10/29/pubmed PY - 2005/11/11/medline PY - 2005/10/29/entrez SP - 113 EP - 9 JF - Acta neurologica Taiwanica JO - Acta Neurol Taiwan VL - 14 IS - 3 N2 - During the worldwide outbreak of severe acute respiratory syndrome (SARS) in 2002-2003, there were 664 probable SARS patients reported in Taiwan. SARS patients usually present with symptoms related to the respiratory system while neurological manifestations have rarely been described. There were three patients who developed axonopathic polyneuropathy 3-4 weeks after onset of SARS; their clinical condition and electrophysiological studies revealed obvious improvement at follow-up. Two SARS patients have experienced myopathy and three other patients developed rhabdomyolysis. These neuromuscular disorders in SARS patients were considered as critical illness neuropathy and myopathy, but the possibility of direct attack by SARS coronavirus on the nerve and muscle could not be excluded. Large artery ischemic stroke were described in five SARS patients with poor prognosis. Multiple factors contributed to this vascular insult included hypercoagulabe status related to both SARS coronavirous and the usage of intravenous immunoglobulin, septic and cardiogenic shock, and possible vasculitis. The relationship between SARS and above neurological problems still needs further clarification. Pathological and microbiological studies are mandatory to delineate this issue. SN - 1028-768X UR - https://www.unboundmedicine.com/medline/citation/16252612/full_citation DB - PRIME DP - Unbound Medicine ER -