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Steroidal saponins from Smilax medica and their antifungal activity.
J Nat Prod. 2005 Oct; 68(10):1489-93.JN

Abstract

Three new steroidal saponins (1-3) were isolated from the roots of Smilax medica, together with the known disporoside A (4). The structures of the new compounds were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS, and HRESIMS). Compounds 1, 2, and 4 demonstrated weak antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata, and C.tropicalis, with MIC values between 12.5 and 50 microg/mL.

Authors+Show Affiliations

Sautour M
Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB UPRES-EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 Boulevard Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
Miyamoto T
No affiliation info available
Lacaille-Dubois MA
No affiliation info available

MeSH

Antifungal AgentsCandidaHumansMexicoMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalSaponinsSmilaxSteroids

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16252913

Citation

Sautour, Marc, et al. "Steroidal Saponins From Smilax Medica and Their Antifungal Activity." Journal of Natural Products, vol. 68, no. 10, 2005, pp. 1489-93.
Sautour M, Miyamoto T, Lacaille-Dubois MA. Steroidal saponins from Smilax medica and their antifungal activity. J Nat Prod. 2005;68(10):1489-93.
Sautour, M., Miyamoto, T., & Lacaille-Dubois, M. A. (2005). Steroidal saponins from Smilax medica and their antifungal activity. Journal of Natural Products, 68(10), 1489-93.
Sautour M, Miyamoto T, Lacaille-Dubois MA. Steroidal Saponins From Smilax Medica and Their Antifungal Activity. J Nat Prod. 2005;68(10):1489-93. PubMed PMID: 16252913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steroidal saponins from Smilax medica and their antifungal activity. AU - Sautour,Marc, AU - Miyamoto,Tomofumi, AU - Lacaille-Dubois,Marie-Aleth, PY - 2005/10/29/pubmed PY - 2005/12/13/medline PY - 2005/10/29/entrez SP - 1489 EP - 93 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 10 N2 - Three new steroidal saponins (1-3) were isolated from the roots of Smilax medica, together with the known disporoside A (4). The structures of the new compounds were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS, and HRESIMS). Compounds 1, 2, and 4 demonstrated weak antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata, and C.tropicalis, with MIC values between 12.5 and 50 microg/mL. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16252913/Steroidal_saponins_from_Smilax_medica_and_their_antifungal_activity_ DB - PRIME DP - Unbound Medicine ER -