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Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum.
J Nat Prod. 2005 Oct; 68(10):1514-8.JN

Abstract

Chemical investigation of the anti-inflammatory Chinese folk medicine Calophyllum membranaceum has resulted in the isolation and characterization of three new xanthones (1-3), one new biphenyl C-glycoside (4), and one new phenylethanoid glycoside (5) along with 17 known compounds. Their structures were characterized on the basis of spectroscopic and chemical methods. Two xanthones, 2,6-dihydroxy-1,7-dimethoxyxanthone (1) and 3,4-dihydroxyxanthone, were found to exhibit selective inhibitory activity against cyclooxygenase-2 (IC(50)=2.99 and 1.80 microM) in vitro.

Authors+Show Affiliations

Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16252917

Citation

Zou, Jian, et al. "Selective Cyclooxygenase-2 Inhibitors From Calophyllum Membranaceum." Journal of Natural Products, vol. 68, no. 10, 2005, pp. 1514-8.
Zou J, Jin D, Chen W, et al. Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum. J Nat Prod. 2005;68(10):1514-8.
Zou, J., Jin, D., Chen, W., Wang, J., Liu, Q., Zhu, X., & Zhao, W. (2005). Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum. Journal of Natural Products, 68(10), 1514-8.
Zou J, et al. Selective Cyclooxygenase-2 Inhibitors From Calophyllum Membranaceum. J Nat Prod. 2005;68(10):1514-8. PubMed PMID: 16252917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum. AU - Zou,Jian, AU - Jin,Daozhong, AU - Chen,Wenliang, AU - Wang,Jian, AU - Liu,Qunfang, AU - Zhu,Xingzu, AU - Zhao,Weimin, PY - 2005/10/29/pubmed PY - 2005/12/13/medline PY - 2005/10/29/entrez SP - 1514 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 10 N2 - Chemical investigation of the anti-inflammatory Chinese folk medicine Calophyllum membranaceum has resulted in the isolation and characterization of three new xanthones (1-3), one new biphenyl C-glycoside (4), and one new phenylethanoid glycoside (5) along with 17 known compounds. Their structures were characterized on the basis of spectroscopic and chemical methods. Two xanthones, 2,6-dihydroxy-1,7-dimethoxyxanthone (1) and 3,4-dihydroxyxanthone, were found to exhibit selective inhibitory activity against cyclooxygenase-2 (IC(50)=2.99 and 1.80 microM) in vitro. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16252917/Selective_cyclooxygenase_2_inhibitors_from_Calophyllum_membranaceum_ L2 - https://doi.org/10.1021/np0502342 DB - PRIME DP - Unbound Medicine ER -