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Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sample.
Neuroimage. 2006 Feb 15; 29(4):1031-9.N

Abstract

Both brain atrophy and T2-weighted white matter hyperintensities (WMH) are common findings in the brains of asymptomatic elderly individuals as well as in disease-specific brains. The study of the relationship between these two salient features is therefore important. To investigate such a relationship, we performed a brain magnetic resonance imaging (MRI) study on 397 asymptomatic individuals aged between 60 and 64 years, who were recruited randomly from a large community sample. WMH were delineated on T2-weighted fluid attenuation inversion recovery (FLAIR) whole brain scans using an automated procedure. The results showed that gray matter reduction, subarachnoid CSF (SA-CSF) increase and lateral ventricular dilation were significantly correlated with WMH load. Deep white matter hyperintensity (DWMH) had significant correlation with all three global atrophy indices, but periventricular white matter hyperintensity (PVWMH) was correlated only with gray matter volume. Voxel-based morphometric (VBM) analysis showed that regional gray matter reduction correlated more closely with WMH load of the proximate region than with WMH elsewhere. The results suggest that WMH have a relationship with brain atrophy in middle age, although the study cannot determine which process, i.e. the development of WMH or atrophy, is primary. The study also demonstrates that DWMH has a more significant relationship with structural brain changes, and may therefore be more functionally relevant than PVWMH. Further delineation of this relationship needs a longitudinal study of the changes in both WMH and indices of brain atrophy.

Authors+Show Affiliations

School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16253521

Citation

Wen, Wei, et al. "Gray Matter Reduction Is Correlated With White Matter Hyperintensity Volume: a Voxel-based Morphometric Study in a Large Epidemiological Sample." NeuroImage, vol. 29, no. 4, 2006, pp. 1031-9.
Wen W, Sachdev PS, Chen X, et al. Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sample. Neuroimage. 2006;29(4):1031-9.
Wen, W., Sachdev, P. S., Chen, X., & Anstey, K. (2006). Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sample. NeuroImage, 29(4), 1031-9.
Wen W, et al. Gray Matter Reduction Is Correlated With White Matter Hyperintensity Volume: a Voxel-based Morphometric Study in a Large Epidemiological Sample. Neuroimage. 2006 Feb 15;29(4):1031-9. PubMed PMID: 16253521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sample. AU - Wen,Wei, AU - Sachdev,Perminder S, AU - Chen,Xiaohua, AU - Anstey,Kaarin, Y1 - 2005/10/25/ PY - 2005/04/29/received PY - 2005/08/23/revised PY - 2005/08/30/accepted PY - 2005/10/29/pubmed PY - 2006/5/18/medline PY - 2005/10/29/entrez SP - 1031 EP - 9 JF - NeuroImage JO - Neuroimage VL - 29 IS - 4 N2 - Both brain atrophy and T2-weighted white matter hyperintensities (WMH) are common findings in the brains of asymptomatic elderly individuals as well as in disease-specific brains. The study of the relationship between these two salient features is therefore important. To investigate such a relationship, we performed a brain magnetic resonance imaging (MRI) study on 397 asymptomatic individuals aged between 60 and 64 years, who were recruited randomly from a large community sample. WMH were delineated on T2-weighted fluid attenuation inversion recovery (FLAIR) whole brain scans using an automated procedure. The results showed that gray matter reduction, subarachnoid CSF (SA-CSF) increase and lateral ventricular dilation were significantly correlated with WMH load. Deep white matter hyperintensity (DWMH) had significant correlation with all three global atrophy indices, but periventricular white matter hyperintensity (PVWMH) was correlated only with gray matter volume. Voxel-based morphometric (VBM) analysis showed that regional gray matter reduction correlated more closely with WMH load of the proximate region than with WMH elsewhere. The results suggest that WMH have a relationship with brain atrophy in middle age, although the study cannot determine which process, i.e. the development of WMH or atrophy, is primary. The study also demonstrates that DWMH has a more significant relationship with structural brain changes, and may therefore be more functionally relevant than PVWMH. Further delineation of this relationship needs a longitudinal study of the changes in both WMH and indices of brain atrophy. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/16253521/Gray_matter_reduction_is_correlated_with_white_matter_hyperintensity_volume:_a_voxel_based_morphometric_study_in_a_large_epidemiological_sample_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(05)00657-9 DB - PRIME DP - Unbound Medicine ER -